OBJECTIVE:To probe into the status quo and the tendency of the utilization of the anti-osteoporosis drugs in hospitals along the Yangtze valley. METHODS: The utilization of the anti-osteoporosis drugs in 177 hospitals of 6 cities along the Yangtze valley during 2004～2008 was analyzed statistically in respect of the orders of consumption sum and defined daily dose (DDD). RESULTS: The total amount of the drugs used for osteoporosis in the hospitals of the Yangtze valley showed year-on-year increase,and its proportion in the total remained at around 1.16% on the consumption sum list. The consumption sum of Diphosphonates showed sharp increase,many of its subcategories had forced into the top 10 places on the list of consumption sum and their rankings were moving forward steadily. Alfacalcidol and Calcitonin dominated the first two places over the 5 years. The top 10 manufacturers in terms of the sales sum of the drugs for osteoporosis were mainly foreign investment manufacturers and joint ventures. CONCLUSION: With the aging of the population and the strengthening of public awareness on health,the drugs used for osteoporosis enjoy a potential market,especially to domestic products and domestic manufacturers.

Humans ; Inlays

Asthma ; diagnosis ; therapy ; Child ; Chronic Disease ; Cough ; diagnosis ; therapy ; Humans

Asthma ; diagnosis ; therapy ; Child ; Humans

The expression of genes have an important effect to gastric cancer chemotherapy.Some genes are related the therapeutic efficacy of drugs,some genes are related the untoward effects of drug,and some genes are related the sensitivity of the tumor to drug.Chemotherapy related genes may play an important guiding role to improve the curative effect of chemotherapy patients.In recent years,the gastric cancer chemotherapy related genes have made great progress,especially in platinum,fluorouracil,paclitaxel and targeted medicine related genes.

Objective To determine the sensitization of Nicotinamide (NA) on None Focused Ultrasound (NFU) on GLC-82 cells in vitro. Methods The subjectives were divided into A、B、C and D four groups, group A was negative control, group B was treated with NA, group C was irradiated with NFU, group D was treated with both NFU and NA; MTT assay was used to evaluate the cytotoxicity of NA and its sensitivity for NFU on GLC-82 cells quantified by calculating the sensitive enhancement ratios (SER); Morphologic change of cells was observed with light microscope, fluorescence microscope and scanning electron microscope;Flow cytometry was performed to determine the percentage changes of apoptosis and distributional percentage of the cell cycle of GLC-82 cells in response to NFU, NA and the effect of its intervention to NFU. Results The cytotoxicity of NA increased in a dose-dependent manner after 24-hour treatment, with the optimal dose range of 1 mg/mL～5 mg/mL. A sub-toxic dose of NA at 3 mg/ml was used in the subsequent experiments; After treatment with NA plus NFU, microvilli and filipodium of GLC-82 cells reduced, shortened and shrunk into corpuscule-shape; The apoptosis rate of group D was more than that in group B and C, with cell cycle arrested at phase S and G2.Conclusion NA can significantly enhance the effect of NFU on GLC-82 cells, which provides evidence for NA as a sensitization to NFU in clinic.

Respirator is one of medical equipment in the first-aid, the clinical risk of it is much higher than the general medical equipment and diagnostic or patient monitor equipment. As a result, the quality control of it is particularly important. Several issues of the quality control of the respirator, such as the pre -purchase technical feasibility study, acceptance and installation after arrival, respirator use and management, respirator-reported loss demonstration and cost- benefit analysis of it are discussed from the angle of clinical engineers and technical personnel.

Objective The various influencing factors in the process of nano-silver preparation were studied in order to prepare nano-silver that has uniformity particle size distribution and good crystallinity. Methods Through the method of liquid reduction at room temperature,the nano-silver powders were prepared directly using silver nitrate as raw material,water as the reactive medium,polyvinylpyrrolidone(PVP) as protecting agent and ammonium formate as reducing agent. By means of EDS and TEM(transmission electron microscopy),the prepared silver particles were characterized. The various influencing factors in the process of preparation were also discussed. Results With the increasing concentration of AgNO3,the particle diameter of nano-silver changed obviously. When the concentration of silver nitrate was 0.25-0.30 mol/L,the size of product is the smallest. With the increasing concentration of reductant,the diameter of nano-silver decreased gradually. While at the concentration of 0.70 mol/L HCOOH,the average diameter of nano-silver is not more than 10 nm. Smaller and more well-distributed silver powder could be prepared at ratio of concentration of PVP to AgNO3 with the value of 1.5-1.0,at which PVP presented effective protection. Conclusions This method can prepare particle of nano-silver which revealed well dispersed and uniform size. The process is stable and reliable,easy to operate,high yields and suitable for industrial production.

This research applied the theory of customer satisfaction model in the evaluation of the clinical information system. By means of qualitative and quantitative methods, it made validity and reliability measurement on the measurement tools in use. In addition, it extracted the structure validity of the factor regulating scale via a factor analysis, and developed the scale for clinical information system measurement These efforts provided the hospitals with the useful measurement tool to improve their information system, promoting positive and practical hospital informationziation.

Child ; Child, Preschool ; Humans ; Hypersensitivity, Immediate ; prevention & control ; Infant ; Primary Prevention