0 05) , RCR and RFER were more higher , RICR and RFIR were greatly lower in analgesia group than those in control group 3d after operation(P0 05), RCR increased markedly 7d after operation(P0 05) Conclusions Postoperative analgesia can help stabilize erythrocyte immunity function

Objective To explore the effect of topical application of sodium hyaluronate on preventing perivascular adhesion of the vein grafts in rabbits. Methods Thirty-six male New Zealand white rabbits, aged 5 months, were randomly and equally divided into 2 groups: groups A and B. Arterial defect model was established by cutting about 1cm artery from the middle part of the dissected left common carotid artery. A section about 3cm was cut from the right external jugular vein, and the harvested vein was inverted and anastomosed end-to-end to the artery defect. After the anastomosis, the adventitia and two anastomoses of the grafted veins in group A were coated locally with 0.2ml sodium hyaluronate. The grafted veins were obtained 1, 2 and 4 weeks after the operation, with the perivascular adhesion of the vein grafts being examined macroscopically before the resection. HE staining and Masson staining were preformed for histological changes of grafted vein wall and the perivascular adhesion of the vein grafts. At 2, 4 weeks postoperation, the perivascular adhesions of the vein grafts were graded by the grading criteria of adhesion in macroscopic evaluation and histological evaluation. Result At 1, 2 and 4 weeks postoperatively, the macroscopic and histological observation found that the perivascular adhesions in group A were looser than those in group B. The macroscopic grade and histological grade were lower in group A than in group B, there was a significant difference between the two groups at 2 and 4 weeks postoperation (P<0.05). Conclusion Topical application of sodium hyaluronate can reduce the perivascular adhesion and is an ideal treatment strategy for preventing perivascular adhesion of vein grafts.

Objective To explore the role of serum inflammatory factors in prediction of infection following internal fixation of closed fractures and its significance for surgical timing and infection prophylaxis.Methods A retrospective study was conducted of the 100 patients who had been treated by internal fixation for closed fracture from January 2014 through July 2016.They were 52 men and 48 women,aged from 24 to 76 years (average,45 years).There were 14 femoral fractures,19 tibial plateau fractures,25 patella fractures,8 pilon fractures,22 tibiofibular shaft fractures,and 12 calcaneal fractures.Of them,21 were inflicted by wound infection.The preoperative and postoperative infection indexes,CRP,ESR,PCT and leukocyte count,were recorded.Logistic regression analysis was conducted to test the correlation between the infection indexes and postoperative infection.The optimal cut-off value was determined by the receiver operating characteristic curve.Results CRP showed a significant correlation with postoperative infection while other indexes did not.The optimal cut-off value was 25 mg/L at one day before operation.Conclusions Preoperative determination of CRP may predict the risk of postoperative infection.CRP ＞ 25 mg/L at one day before operation may indicate the following day is not suitable for surgery and active infection prophylaxis should be conducted after surgery.

Tumor tissues are composed of tumor cells and complicate microenvironment. Tumor associated macrophages (TAMs) as an important component in tumor microenvironment, play fundamental roles in tumor progression, metastasis and microenvironment regulation. Recently, studies have found that nanotechnology, as an emerging platform, provides unique potential for cancer imaging and therapy. With the nanotechnology, TAMs imaging presents direct evidence for cancer development, progression, and the effectiveness of cancer treatments; it also can regulate the immunosuppression of tumor microenvironment and improve therapeutic efficiency through TAMs targeted killing or phenotypic transformation. In this article, we illustrate the function of TAMs and review the latest development in nano-carriers and their applications in tumor associated macrophage targeting cancer imaging and therapy.

Objective:To explore the safety and efficacy of continuous pair triangular flap plasty in the treatment of webbed penis.Methods:The clinical data of 5 patients with webbed penis treated by continuous pair triangular flap plasty in Tianjin Baodi Hospital from November 2020 to January 2021 were retrospectively analyzed. The average age was 18.2 (15-24) years old. Physical examination showed a webbed fusion between the ventral skin of the penis and the scrotal skin, the penoscrotal angle disappeared and penile erection was limited. The web extended to or exceeded the middle of the penis in the 5 cases. None of the 5 patients had other penile malformations. Taking the ventral midline of the penis and the junction of the penis and scrotum as the origin, a " Z-shaped" incision was made above and below it respectively, and two triangular flaps with the same size and shape but opposite direction were formed respectively. Then the triangular flaps were switched and sutured.Results:The average operation time of five patients was 13(10-20) minutes. The operative average blood loss was 1.6(1-3)ml. All patients had good wound healing and no surgical complications. Three months after operation, the appearance of the penis was satisfactory and erection was unrestricted.Conclusions:Continuous pair triangular flap plasty overcomes the disadvantages of traditional operation, and has the advantages of simple operation, good operation results and few complications. It is a good choice for the treatment of webbed penis.