1.Study on the Effects of Treatment Compliance on Short-term Clinical Outcome among Community Patients with Type 2 Dia- betes Mellitus in China
Hongchao LI ; Haijing GUAN ; Guo’en LIU
China Pharmacy 2019;30(18):2570-2576
OBJECTIVE: To provide reference for improving the treatment compliance and therapeutic effect of patients with type 2 diabetes mellitus (T2DM) in China. METHODS: The follow-up data was from the issue of Pharmacoeconomic Study of Diabetic Drugs in China, which was conducted by China Center for Health Economic Research (CCHER) of Peking University. Using follow-up endpoint HbA1c level as clinical output indicator, univariate analysis and multivariable regression analysis of binary and numerical variables were performed to evaluate the effect of treatment compliance on short-term clinical outcomes. RESULTS: Totally 2 236 community T2DM patients were included for the analysis. The patients with good and poor medication compliance accounted for 23.48% and 76.52%; the patients with good and poor blood glucose monitoring compliance accounted for 7.02% and 93.98%; 66.3%, 23.5% and 10.2% of the patients had good, medium and poor diet control compliance, respectively. Univariate analysis showed that there was a significant difference in the “good control” group of blood glucose and the “poor control” group of blood glucose in terms of patient age, body mass index, education level, duration of disease, exercise, and eating habits,etc (P<0.05). Similar results were obtained in the analysis of multiple Logistic regression and multivariate loglinear regression models, that is, blood glucose monitoring compliance and diet control compliance had significant positive effects on end-point HbA1c (P<0.05), but drug compliance had no significant effect (P>0.05). CONCLUSIONS: The treatment compliance among community patients with T2DM in China was generally poor. After controlling for other variables, patients’ treatment compliance has a positive effect on end-point HbA1c, especially better blood glucose monitoring compliance and diet control compliance contribute to blood glucose control, but medication compliance has no significantly effect.
2.Study on Influential Factors of Medication Compliance among Community Patients with Type 2 Diabetes Mellitus in China
Hongchao LI ; Haijing GUAN ; Guo’en LIU
China Pharmacy 2019;30(24):3448-3451
OBJECTIVE: To provide reference for improving medication compliance and therapeutic efficacy in community patients with type 2 diabetes mellitus (T2DM) in China. METHODS: The data was from the “Economic Study of Diabetic Medications in Patients with T2DM in China”, which was conducted by China Center for Health Economic Research of Peking University. Both univariate analysis and Logistic regression model were used for single factor analysis and multiple factor analysis of medication compliance. RESULTS: Totally 2 236 community T2DM patients were included. The rate of good medication compliance was estimated at as low as 23.48%. Monthly household income and duration of the disease had significant impact on medication compliance. Incidence of good the medication compliance for patients with monthly household income ≥6 000 yuan and during 3 000-<6 000 yuan, compared to those with monthly household income <3 000 yuan, were 70.8% [95%CI(0.532,0.944)] and 78.5% [95%CI(0.614,1.004)] respectively. Incidence of good medication compliance for the patients with 5 to 10 years and >10 years of disease duration, compared to those with <5 years of disease duration, were 69.0% [95%CI(0.542, 0.878)] and 59.1% [95%CI(0.459, 0.760)] respectively. CONCLUSIONS: The medication compliance among community patients with T2DM in China was generally poor. Longer duration of the disease and higher monthly household income are associated with poorer medication adherence.