BACKGROUND: There are many therapeutic options for vitiligo such as phototherapy, steroids, transplantation of blister tops or minigrafts, and the application of cultured melanocytes. OBJECTIVE: The purpose of this study was to evaluate the effectiveness of autologous suction blister grafting for the treatment of vitiligo. METHODS: Blisters were made by suction at 450 mm Hg from the buttock or upper thigh as donor sites. The epidermal sheet was then grafted to the recipient site. Two weeks after grafting, topical PUVA, or topical corticosteroid application were recommanded. RESULTS: The restoration of pigment including partial recovery was seen in 130 of 144 patients with vitiligo; grade 0 in 14 patinets(10%); grade 1 in 21(36%); grade 2 in 22(27%); grade 3 in 28(27%). In type B vitiligo, repigmentation was seen in 71 of the 74 patients; grade 0 in 3 patinets; grade 1 in 21; grade 2 in 22; grade 3 in 28. However, repigment in type A was seen in 58 of the 70 patients; grade 0 in 11 patients; grade 1 in 33; grade 2 in 16; grade 3 in 10. The repigmentation rate was related to age in both type A and B. The rate was higher in the "less than 31-year-old" group than in the "over 31-years-old" group. (p<0.01, Mann-Whitney test). CONCLUSION: The author experienced different repigmentation according to the types of vitiligo and patient age, that is,it was more effective in type B vitiligo than type A, and the younger the age of the patient, the better the results.
Blister* ; Buttocks ; Humans ; Melanocytes ; Phototherapy ; Steroids ; Suction* ; Thigh ; Tissue Donors ; Transplants* ; Vitiligo*

No abstract available.
Eyebrows* ; Hair* ; Vitiligo*

This study was done to observe the statistical difference on bullous skin disease patients (pemphigus, bullous pemphigoid, dermatitis herpetiformis, epidermolysis bullosa) who visited the department of dermatology, Kyungpook National University Hospital,from January 1966 to Deceniber 1985, For those 24 cases which tested positive under direct immunofluorescent (DIF) testing, agreement percentage of histopathologic diagnosis was compared. The results were summarized as follows : 1) 51 of 45,091 new outpatients (0.113%) were bullous skin disease patients. 2) By sex, age and monthly distribution, there was no significant difference, though epidermolysis bullosa was seen for the most part in those under 10 years of age. 3) By individual disease distribution, the pemphigus cases numbered 8, of which most cases were within the 30~60 year age group. Bullous pemphigoid cases numbered 14, of which most cases were over 50 years of age. Female patients were 2.5 times more common than male patients. Dermatitis herpetiformis cases numbered 20, and were relatively diminished in recent years. The peak age group was the 3rd decade. Epidermolysis bullosa numbered 9 cases. 4) The compatibility of the histopathologic diagnosis to the DIF diagnosis in 24 DIF positive cases indicated that of DIF positive pemphigus the histopathologic diagnrsis agreed with the DIF diagnosis in 75%, of bullous pemphigoid, 58% and of dermatitis herpetiformis, 50%.
Dermatitis Herpetiformis ; Dermatology ; Diagnosis ; Epidermolysis Bullosa ; Female ; Gyeongsangbuk-do ; Humans ; Male ; Outpatients ; Pemphigoid, Bullous ; Pemphigus ; Skin Diseases, Vesiculobullous* ; Statistics as Topic*

BACKGROUND: Hormones influence various normal biological processes in the skin and hairs. OBJECTIVE: This study was undertaken to investigate the presence of estrogen receptors(ER) and progesterone receptors (PR) in the skin and to assess differences in sex and age. METHODS: We examined seven normal volunteers' skin. The mouse monoclonal antibodies against human ER and PR were used to identify the localization of ER and PR in the frozen tissue sections by using a standard two stage indirect immunoperoxidase technique. RESULTS: The granular layer of epidermis and infundibulum of hair follicle in all the samples showed strong positivity of PR. Although each skin section did not contain all skin appendages, most of the samples showed that eccrine gland duct, inner root sheath of hair follicle stained weakly positive of PR. ER was not demonstrate in all samples epidermis. CONCLUSION: PR was presented in the granular layer of epidermis, infundibulum of hair follicle, eccrine gland duct, and inner root sheath of hair follicle. Therefore, we might suspect that the progesterone probably contributes to the keratinization of the skin because these positively staining sites are prior to complete keratinization layers.
Animals ; Antibodies, Monoclonal ; Biological Processes ; Eccrine Glands ; Epidermis* ; Estrogens* ; Hair ; Hair Follicle ; Humans ; Immunoenzyme Techniques ; Mice ; Pituitary Gland ; Progesterone* ; Receptors, Progesterone* ; Skin

In this report we will highlight an interesting 3 year case of a halo nevus on the back of a 13-year-old Korean girl. This was a single halo nevus with a central pinkish mole and a depigmented patch, 20 mm in diameter. The patient underwent an autologous suction blister graft on the lesion. The halo nevus was completely repigmented except for the marginal rim. At a 4 month follow-up, a new whitish halo was observed around the central pinkish mole. At this point the central nevus was excised and examined with a H & E stain and an immunohistochemical stain with an anti-Ig G antibody. After the excision of the central mole, repigmentation was completed and this condition persisted at a 3-year-follow-up.
Adolescent ; Blister* ; Female ; Follow-Up Studies ; Humans ; Nevus ; Nevus, Halo* ; Recurrence* ; Suction* ; Transplants*

We report a case of acantholytic dyskeratotic epidermal nevus in a 28-year-old female. The patient showed unilateral, asymptomatic, grouped, 2 mm sized, brownish, follicular ant non-follicular, keratotic papules disposed along Blaschko´s lines on the right side of th back, flank and abdomen. She had had this condition for 4 years. The biopsy specimen obtaine, from the abdomen showed hyperkeratosis, parakeratosis, acanthosis, acantholytic suprabasal clefts, corps ronds, and grains. Although cryotherapy with liquid nitrogen was per formed on half of the lesions, the whole skin lesions healed with focal hypertrophic scars 4 weeks later. There was no recurrence after a 12 months follow-up period. To our knowledge this is the first reported case of acantholytic dyskeratotic epidermal nevus in Korean dermatologi, literature.
Abdomen ; Adult ; Ants ; Biopsy ; Cicatrix, Hypertrophic ; Cryotherapy ; Darier Disease* ; Female ; Follow-Up Studies ; Humans ; Nitrogen ; Parakeratosis ; Recurrence ; Skin

A 37-year-old female was presented with an epidermal cyst on her lower back. Histopathologic examination was consistent with an epidermoid cyst with seborrheic verrucalike cyst wall and acantholytic change was also found in the cyst wall. Human papillomavirus(HPV)-specific DNA sequences in paraffin-embedded tissue section were not detected by polymerase chain reaction using HPV consensus primers.
Acantholysis* ; Adult ; Base Sequence ; Consensus ; Epidermal Cyst* ; Female ; Humans ; Polymerase Chain Reaction

BACKGROUND: There are prerequisites for fungal nail infection: fungal organism, susceptible host, and environments with damaged nail. OBJECTIVE: The purpose of this study was to evaluate the growth rate of the great toe nail in distal subungual onychomycosis(DSO). MATERIALS AND METHODS:: The subjects are 60 adult patients with DSO and 19 age- and sex-matched controls with tinea pedis but no DSO. The growth rate of the great toe nail was measured. Data were evaluated with Mann-Whitney U-test and regression analysis using the statistical program for PC. RESULTS: The growth rate of the patients group showed a decrease against that of the controls. The equation for expected nail growth rate of specific age and sex was as follows: the expected nail growth rate(mm/day) = 0.07382 + (0.01498 × G) - (0.00033 × Age) - (0.00669 × S): if a person has DSO, G is 1, and if he has no DSO, G is 2; if a person is male, S is 1, and, female, 2. CONCLUSION: Patients with DSO often have a decreased growth rate of the nail compared with that of the controls. The authors propose the equation of expected nail growth rate in persons with or without DSO, and think that the growth rate of the nail is one of factors in the pathogenesis of onychomycosis.
Adult ; Female ; Humans ; Male ; Onychomycosis* ; Tinea Pedis ; Toes*

Herpes zoster in infancy occurs very rarely. And it may be the primary clinical manifestation of reactivation of latent varicella-zoster virus infection acquired transplacentally during intrauterine life. We report a case of herpes zoster in right T2 dermatome in a normal 3-month-old boy, The patient had no history of chickenpox and varicella vaccination. And his mother did not recall herself varicella infection, though she was exposured to chickenpox patient at 7 months of pregnancy. Laboratory findings demonstrated that varicella-zoster Ig-G and Ig-M antibodies were 0.94, 0.12 respectively ( EIA method, negative, <0.8; positive, >1.0) at the second day of vesicular eruption. Fourteen days after vesicular developing, the Ig-G and Ig M titers were rising to 1.92, and 0.47 respectively. His mother's varicella-zoster Ig-G and Ig-M antihodies were 2.64, 0.14 respectively. The baby received acyclovir treatment and the skin lesions healed rapidly without sequela. In this case, although the cause was unclear whether it was a mother-child infection, the patient was suspected subclinical intrauterine varicella-zoster virus infection during pregnancy.
Acyclovir ; Antibodies ; Chickenpox ; Herpes Zoster* ; Herpesvirus 3, Human ; Humans ; Infant* ; Male ; Mothers ; Pregnancy ; Skin ; Vaccination

We report a case of fixed-type sporotrichosis in a 12-month-old infant, who presented with a well-defined scaly erythematous patch on the right lateral nasal root area of approximately 2.5 months duration. Hiopsy revealed pseudoepitheliomatous hyperplasia with chronic granulomatous inflammation in dermis and PAS-positive fungal spores in the stroma. Sporothrix schenckii was identified with fungal culture of biopsy specimen. The lesion was responded to treatment. with itraconazole(3mg/kg) for 12 weeks, without relapse at 5-month follow-up.
Biopsy ; Dermis ; Follow-Up Studies ; Humans ; Hyperplasia ; Infant ; Inflammation ; Itraconazole ; Recurrence ; Spores, Fungal ; Sporothrix ; Sporotrichosis*