1.Urodynamic Characteristics of Women with Severe Uterine Prolapse.
Gun Pyung KIM ; Dong Deuk KWON ; Yang Il PARK
Korean Journal of Urology 2000;41(12):1506-1510
No abstract available.
Female
;
Humans
;
Urodynamics*
;
Uterine Prolapse*
2.Clinical Significance of Transperineal Duplex Doppler Ultrasonography in the Diagnosis of Arteriogenic Impotence.
Gun Pyung KIM ; Kwang Sung PARK ; Soo Bang RYU
Korean Journal of Urology 2000;41(11):1384-1388
No abstract available.
Diagnosis*
;
Female
;
Impotence, Vasculogenic*
;
Male
;
Ultrasonography, Doppler, Duplex*
3.Experimental animal model for preeclampsia by the infusion of nitric oxide synthase inhibitor and reverse of preeclampsia by high dose L-arginine infusion.
Hyung Gun LEE ; Jong Kun LEE ; Young Ok LEW ; Dae Young CHUNG ; Dong Choon PARK ; Jae Hoon KIM ; Jong Chul SHIN ; Dae Hoon KIM ; Soo Pyung KIM
Korean Journal of Obstetrics and Gynecology 1999;42(12):2768-2775
OBJECTIVES: To learn which inhibition of nitric oxide synthase with L-nitro arginine methylester(L-NAME) induces a preeclampsia-like syndrome in pregnant rabbits and high dose of L-arginine reverse the adverse changes induced by nitric oxide synthesis inhibition in pregnant rabbits. MTERIAL AND METHOD: Twenty Newzealand rabbits with 22-days of gestation were injected subcutaneously with 400mg of L-NAME for 7days and 100mg/kg L-arginine was also given intravenously 10 of 20 L-NAME injected pregnant rabbits. They are compared with the control group in which same volume of saline was subcutaneously injected to 5 rabbits with same condition. They were anesthesized by ketamine 50 mg/kg and roupum 2 mg/kg intramuscularly. Cutdown of femoral artery was performed and 22 gauge angioneedle was inserted. On manometer,three way catheter was connected, zeroed with saline, and blood pressure was read. Blood samples were taken from the vein of ear and checked for count of blood cells and bood chemistry (BUN/Cr, GOT/GPT, LDH, Uric acid). Urine protein was measured with nelaton catheterized urine. We injected drugs for 7 days begining on 22 days after mating and performed cesarian section to deliver fetus. To observe their effects on organs, lung, liver, placenta and kidney were taken and fixed with formalin. The sliced kidney tissue in thickness of 1 mm, was fixed with glutaraldehyde for electron microscopy and stored at 4degree C. Special staining was done for closed observation of pattern changes. For statistical analysis, mean+/-SEM was used. The control and experimental groups were compared by unpaired t-test and the differences were significant if probability level is less than 0.05(<0.05). RESULT: Mean blood pressure(MAP) in the experimental group I was significantly high compared to the control group(P<0.05). There was no significant differences in MAP between experimental group II and control group. Urine Protein, BUN, Cr, GOT/GPT, LDH, platelet count in the experimental group I was significantly high(p<0.05) compared to the control group. There was no significant difference between experimental group II and control group. In light microscopic examination, lung, liver, kidney, placenta showed specific finding in experimental group I. Misconstructive of glomerulus in the experimental kidney was well preserved under EM examination. Interstitium of kidney was widened by increase of mesangial matrix. Mild effacement of foot process and cytoplasm of proximal tubule containing electron dense myelin figure like structure were observed. CONCLUSION: Long term injection of L-arginine analogue produced preeclampsia like syndrome and pathologic changes of organ system in pregnant rabbits. Concurrent high dose of L-arginine reversed such chages.
Arginine*
;
Blood Cells
;
Blood Pressure
;
Catheters
;
Chemistry
;
Cytoplasm
;
Ear
;
Femoral Artery
;
Fetus
;
Foot
;
Formaldehyde
;
Glutaral
;
Ketamine
;
Kidney
;
Liver
;
Lung
;
Microscopy, Electron
;
Models, Animal*
;
Myelin Sheath
;
NG-Nitroarginine Methyl Ester
;
Nitric Oxide Synthase*
;
Nitric Oxide*
;
Placenta
;
Platelet Count
;
Pre-Eclampsia*
;
Pregnancy
;
Rabbits
;
Veins
4.A Case of Leiomyoma in Vaginal Orifice.
Hyung Gun LEE ; Byoung Dae YOO ; Jin Woong SHIN ; Duck Yeong RO ; Dou Kang KIM ; Soo Pyung KIM
Korean Journal of Obstetrics and Gynecology 1997;40(6):1291-1293
Leiomyomas of the vagina are rare benign solid tumors. A leiomyoma arises frommuscle in the round ligament and appears as a firm movable tumor deep in the substanceof the labium majus, but minority of these tumors occur in vaginal wall. A case of a 39year old woman with leiomyoma of the vaginal orifice was reported with a brief review ofliterature.
Female
;
Humans
;
Leiomyoma*
;
Round Ligament of Uterus
;
Vagina
5.A Case of Cavernous Hemangioma of the Urinary Bladder.
Gun Pyung KIM ; Dong Deuk KWON ; Bong Ryoul OH ; Kwang Sung PARK ; Soo Bang RYU ; Yang Il PARK
Korean Journal of Urology 1999;40(5):655-658
Hemangiomas of the bladder are a rare but recognized cause of gross hematuria. In many cases, the tumor shows the characteristics of an iceberg, with considerable extravesical extension making endoscopic management less suitable. In spite of its benign nature, bladder hemangioma may grow continuously, and spontaneous regression is rare. They need to be adequately treated to avoid recurrent fatal hematuria and appropriately followed up to detect recurrency or persistency. We report a case of cavernous hemangioma of the bladder in 26-year-old woman, who presented recurrent gross hematuria and was treated with partial cystectomy.
Adult
;
Cystectomy
;
Female
;
Hemangioma
;
Hemangioma, Cavernous*
;
Hematuria
;
Humans
;
Ice Cover
;
Urinary Bladder*
6.Treatment of Rectal Prolapse by a Perineal Rectosigmoidectomy.
Pil Gun RHYU ; Moo Jun BAEK ; Moon Soo LEE ; Chang Ho KIM ; Ok Pyung SONG ; Moo Sik CHO
Journal of the Korean Surgical Society 1998;55(6):868-873
BACKGROUND: The optimum surgical treatment for rectal prolapse is controversial, and many different operations have been described. The aim of this study is to evaluate the results of a perineal procedure for the treatment of rectal prolapse. METHODS: Between February 1990 and March 1997, 16 consecutive patients underwent perineal rectosigmoidectomy for a complete rectal prolapse. One patient was lost to follow up. The remaining 15 patients were followed up for an average of 58.4 (9~94) months, and clinical and functional outcomes were evaluated. RESULTS: There were 8 males and 7 females, and ages ranged from 18 to 65 years. The mean prolapse duration was 10.7 (0.25~30) years. There were no postoperative deaths. Two patients developed postoperative complications (one wound infection and the other wound hematoma). Five patients had fecal incontinence prior to surgery. Three of the five patients had improved fecal incontinence after the procedure. There were three recurrences (recurrence rate of 20%): one of them underwent a Delorme operation at our institution and others had no treatment. CONCLUSION: A perineal rectosigmoidectomy is a safe and effective operation for the primary treatment of rectal prolapse and has low mortality and morbidity.
Fecal Incontinence
;
Female
;
Humans
;
Lost to Follow-Up
;
Male
;
Mortality
;
Postoperative Complications
;
Prolapse
;
Rectal Prolapse*
;
Recurrence
;
Wound Infection
;
Wounds and Injuries
7.Differential diagnosis of Thrombocytopenia newly developed during pregnancy.
Ji Young KWON ; Ok Kyoung KIM ; Young LEE ; Sa Jin KIM ; Jong Chul SHIN ; Jong Gun LEE ; Soo Pyung KIM ; Jong Gu RHA
Korean Journal of Obstetrics and Gynecology 2006;49(3):544-552
OBJECTIVE: Gestational thrombocytopenia has a mild course as a common problem during pregnancy, whereas idiopathic thrombocytopenic purpura (ITP) presents with a chronic or moderate to severe course. Very few studies have been conducted so far to discriminate between the two diseases. This study was aimed to identify factors predictive of the subsequent development of ITP among pregnant women presenting with thrombocytopenia. METHODS: From January 1999 to June 2005, a total of 58 pregnant women newly diagnosed with thrombocytopenia were recruited for the study. Among them, 33 were finally diagnosed with gestational thrombocytopenia and the other 25 with ITP. The clinical factors for each of ITP and neonatal thrombocytopenia were evaluated, and final outcomes were also described. RESULTS: On multivariate analysis, thrombocytopenia diagnosed before 28 completed weeks and platelet count of less then 50 x 10(9)/L at the time of its presentation were found to be independently predictive of ITP (p<0.001 and p=0.004 respectively). In addition, platelet count of less then 20 x 10(9)/L at nadir during pregnancy was a significant risk factor for neonatal thrombocytopenia (p=0.013). CONCLUSION: The onset time of thrombocytopenia and platelet count at its presentation remain useful parameters to discriminate ITP from gestational thrombocytopenia. These findings may help in allowing an appropriate antenatal care and postpartum follow up.
Diagnosis, Differential*
;
Female
;
Follow-Up Studies
;
Humans
;
Multivariate Analysis
;
Platelet Count
;
Postpartum Period
;
Pregnancy*
;
Pregnant Women
;
Purpura, Thrombocytopenic, Idiopathic
;
Risk Factors
;
Thrombocytopenia*
;
Thrombocytopenia, Neonatal Alloimmune
8.The Outcome of Pregnancy Combined with Idiopathic Thrombocytopenia Purpura and the Effect of Pregnancy on the Severity of This Disease.
Sue Youn KIM ; Ji Young KWON ; Yoon Sung JO ; Sa Jin KIM ; Jong Chul SHIN ; Jong Gun LEE ; Jong Gu RHA ; Soo Pyung KIM
Korean Journal of Perinatology 2006;17(4):397-404
OBJECTIVE: The incidence of idiopathic thrombocytopenic purpura (ITP) is greatest in female during their childbearing years, so the concurrence of pregnancy and ITP is not unusual. Numerous studies have examined the outcomes of newborns, whereas fewer studies have been conducted with regard to the morbidity of obstetric patients with ITP. This study was aimed to find the outcome of pregnancy combined with ITP and the influence of the pregnancy on the severity of this disease. METHODS: From January 1996 to December 2005, a total of 62 pregnant women with ITP and their 73 deliveries were recruited for the study. Among them, 38 were diagnosed with ITP during pregnancy and the other 24 had pre-existing ITP before pregnancy. RESULTS: The severity of thrombocytopenia was exacerbated during pregnancy, but recovered to a level of non-pregnant period after delivery in most cases. The outcome of pregnancy of all the patients was uneventful except each one case of fetal demise at 35 gestational weeks and preterm delivery at 30 gestational weeks. One patient suffered from multiple subdural hemorrhage during pregnancy, which was spontaneouly recovered. Twenty newborns (27.8%) had transient congenital thrombocytopenia and 18 of them required treatment for hemostatic impairment. CONCLUSION: For women with ITP, Pregnancy can affect the severity of ITP, but life-threatening complication was almost lacking. Although, in not a few cases, there may need to treat both mothers and infants to raise their platelet counts, most mothers with ITP can proceed with their pregnancies and delivery healthy infant without complication.
Female
;
Hematoma, Subdural
;
Humans
;
Incidence
;
Infant
;
Infant, Newborn
;
Mothers
;
Platelet Count
;
Pregnancy*
;
Pregnant Women
;
Purpura*
;
Purpura, Thrombocytopenic, Idiopathic
;
Thrombocytopenia*
;
Thrombocytopenia, Neonatal Alloimmune
9.The effect of the sera from severe preeclamptic patients on endothelial cell viability and endothelin-1 in cultured human umbilical vein endothelial cells.
Yong Yook KIM ; Wook Yull NA ; Jong Kun LEE ; Young LEE ; Eun Jeong BAIK ; Jong Gu RHA ; Sa Jin KIM ; Hyung Gun LEE ; Jong Chul SHIN ; Soo Pyung KIM
Korean Journal of Obstetrics and Gynecology 2000;43(7):1162-1167
OBJECTIVES: In order to assess the effects of sera from severe preeclamptic patients on endothelial cell viability in vitro and endothelin-1 synthesis in cultured human umbilical vein endothelial cells. METHODS: The cultured human umbilical vein endothelial cells were incubated with media containing 10% sera from women with either preeclamptic patients or normal pregnancies for 24 hours or 48 hours. After then, their viability was measured by colorimetric MTT{3-(4,5-dimethylthiazol-2yl)2,5-diphenyl tetrazolium bromide} assay and their production of endothelin-1 was measured. We also measured the serum levels of endothelin-1 level in sera obtained from the normal and severe preeclamptic pregnancies. RESULTS: The calorimetric MTT assay revealed that after 24 hours, the absorbances in the media treated with normal pregnancies and severe preeclampsia sera were 0.0718+/-0.0078 and 0.0837+/-0.0129, respectively and after 48 hours, they were 0.1133+/-0.0103 and 0.1268+/-0.0186, respectively. Serum obtained from severe preeclampsia did not affect endothelial cell viability. 2. The serum mean levels of endothelin-1 in normal and severe preeclamptic pregnancies were 22.66+/-8.6 fmol/ml and 48.98+/-25.27 fmol/ml. The mean level in preeclamptic sera was significantly higher than that of normal pregnant women. (P<0.05) 3. After 24 hours, the mean amount of endothelin-1 stimulated by normal pregnant and severe preeclamptic sera were 37.52+/-18.41 fmol/ml and 97.58+/-53.64 fmol/ml, respectively. The mean amount of endothelin-1 in preeclamptic sera-treated cells was significantly higher than that of normal pregnant sera-treated cells. (P<0.05). CONCLUSION: The sera from severe preeclamptic women do not affect cell viability but act selectively on specific activation of their function such as endothelin-1 production. And it is necessary that the identification and isolation of the putative serum factor(s) will be performed to resolve the pathogenesis in future.
Cell Survival
;
Endothelial Cells*
;
Endothelin-1*
;
Female
;
Human Umbilical Vein Endothelial Cells*
;
Humans
;
Humans*
;
Pre-Eclampsia
;
Pregnancy
;
Pregnant Women
10.Cord Blood Erythropoietin Complicated By High Risk Pregnancies.
Seock Won KIM ; Sa Jin KIM ; Gui Se Ra LEE ; In KWUN ; Jae Dong LEE ; Hyung Gun LEE ; Jung Hui PARK ; Gi Hong JIN ; Jong Chul SHIN ; Su Pyung KIM
Korean Journal of Obstetrics and Gynecology 2000;43(6):1062-1065
OBJECTIVE: To investigate the relationship between umbilical plasma erythropoietin(epo) concentrations and umbilical cord pH in high risk pregnancies. METHODS: We measured epo concentrations and gas in 103 cases of cord blood obtained from 88 cesarean section (15 of twin) composed of 39 cases of normal control (12 of normal twins), 45 cases of high risk pregnancies and 4 cases of unclassified group using an RIA kit from december,1998 to December, 1999. Statistical analysis was performed using the student's t test and regression analysis. P values less than 0.05 were considered statistically significant. RESULTS: Umbilcal plasma epo concentrations revealed significant inverse correlation (P<0.05) with umbilical acidosis and cord blood epo levels, and it were significantly higher in GDM and IUGR than normal pregnancies (control: 1.60 1.15, n=39 versus GDM: 7.78 7.18, n=11 versus IUGR: 64.77 90.57 n=10, p<0.05), but 11 cases of fetal distress and 13 cases of preeclampsia did not differ significantly from umbilical plasma epo of normal control. CONCLUSIONS: Elevated epo concentrations in cord blood indicate fetal hypoxia and It is significantly increased in IUGR and GDM, these findings show that cord blood epo may serve as a clinically useful marker for chronic fetal hypoxia.
Acidosis
;
Cesarean Section
;
Erythropoietin*
;
Female
;
Fetal Blood*
;
Fetal Distress
;
Fetal Growth Retardation
;
Fetal Hypoxia
;
Hydrogen-Ion Concentration
;
Plasma
;
Pre-Eclampsia
;
Pregnancy*
;
Umbilical Cord