Objective To observe the clinical effects of Leigongtong-duogan Pian combine with total glucosids of Paeony Capsules to treat chronic idiopathic urticaria.Methods One hundred and thrity -eight patients are observed in this test , and they are divided into 3 groups.Group 1:were given Leigongtongduogan Pian 10 mg orally , 3 times a day and total glucosids of Paeony Capsules 600 mg orally, 3 times a day.Group 2:were given mizolastine 10 mg orally, onces a day;and total glucosids of Paeony Capsules 600 mg orally, 3 times a day.Group 3:were given mizolastine 10 mg orally onces a day.Duration in the three groups were for 28 days, if someone recovers within 28 days, he also continues until the end.The itching intensity and amount of rush and the size of rush , even the frequency of the outbreaks of rush are observed on the 7th day and on the 14th day and on the 28th day.Results The clin-ical effective rate of group 1 is 91.30%, however group 2 is 77.14%and group 3 is 71.43%.Conclusion The clinical effects of Leigong-tongduogan Pian combine with total glucosids of Paeony Capsules to treat chronic idiopathic urticaria are remaked and its adverse drug reactions are lowered.