Objective To analyze the clinicopathological features of diffuse large B -cell lymphoma(DL-BCL)and its relationship with prognosis.Methods The clinical data of 64 cases of DLBCL patients were retrospec-tively analyzed,and relationship between the clinical pathological features and efficacy were also analyzed.Results There were 25 cases of patients with extranodal infiltration,accounting for 39.06%.There were 26 cases of anemia in patients with newly diagnosed,accounting for 40.63%.Molecular/immune typing results showed,GCB(biochemistry center B cell -like)patients with 19 cases,accounted for 29.69%.45 patients with non -GCB,accounted for 70.31%.ECOG performance status indicators,hemoglobin levels and B symptoms were statistically significant in the two groups(χ2 =6.218,6.100,5.042,all P <0.05).Serum LDH level,large lesions were statistically significant difference(χ2 =10.005,9.227,all P <0.05).Extranodal infiltration,peripheral blood lymphocyte counts,T cell infil-tration,Ki67 and Bcl -6 and other indicators of the difference were not statistical significant (all P >0.05 ). Conclusion Uygur patients with DLBCL mainly are GCB subtype,ECOG score,hemoglobin level,B symptoms,LDH levels and large lesions can affect the prognosis.