Objective To observe the effects of Chinese herbal meridian and vessel deoppilant compound on the dysfunction of endothelium-dependent dilation (EDD) of simple obesity patients, and explore its mechanism. Methods Sixty-five obese patients with dysfunction of EDD (denoted by FMD: flow mediated brachial artery vasodilatation rate) were found through the prehminary high-resolution vascular ultrasound check, and randomized into the therapy group (treated with Chinese herbal meridian and vessel deoppilant compound) and the control group. The therapy group took Xinxiang Shuluo 2# capsules three times a day, 3 gram each time, and the control group was given the same doses of starch capsules. The experiment lasted 12 weeks. Before and after the experiment, FMD and inner diameter of brachial arteries (DO) of all the patients were measured, and the changes of total cholesterol (TC) and trigiyceride (TG) in serum were compared. Results FMD of the therapy group was significantly higher than the control group (P

Objective:To discuss the clinical features, diagnosis and treatment of linear scleroderma (LS).Methods:A case of LS diagnosed in the Second Hospital of Shandong University in October 20, 2020, was reported and the clinical features and pathological documentation of the disease reported in the literature were reviewed.Results:A 24-year-old woman presented cicatricial alopecia on the left frontoparietal area and facial atrophy for about 10 years. Two years before, she began to suffer ptosis and neurological complaints. Clinical features of different stages of the disease are presented. All 15 patients reported in the literature were analyzed, with a median of 22 years and a male to female ratio of 9∶6. There were 4 cases of linear scleroderma with ipsilateral drooping eyelids and lateral contraction, 3 cases of linear scleroderma with demyelinating lesions, combined with lateral contraction, 3 cases of linear scleroderma combined with lateral atrophy, and 1 case of linear scleroderma with ipsilateral facial spasm. Two cases were with the chest sclerosing spot. Two cases of linear scleroderma were with epileptic seizure and white matter demyelination lesion. Six cases were treated with hormone, 2 cases were treated with methotrexate. One case was treated with both hormone and methotrexate. One case was treated with botulinum toxin. Three cases were treated with surgical correction of eyelid ptosis. One case was treated with ultraviolet A1 radiation phototherapy and 1 case was treated with vitamin therapy.Conclusions:Patients with scleroderma may have ipsilateral facial atrophy, blepharoptosis and facial spasm. Some patients involving the nervous system may have epilepsy and myelitis. And demyelinating lesions can be seen in magnetic resonance imaging. Localized scleroderma may develop into systemic scleroderma. Therefore, it is recommended to combine immunosuppressants as soon as possible to control the development of the disease if necessary.