1.Influence of atorvastatin on scavenger receptor of monocytes/macrophages in patients with coronary heart disease
Guiyue ZHU ; Xinglei ZHU ; Qingxin GENG
Chinese Journal of Pathophysiology 1986;0(02):-
AIM: To observe activity of scavenger receptor of macrophage derived from monocytes, the change of inflammation factor in plasma (including CRP, sICAM-1, sVCAM-1) and the influence of atorvastatin on activity of scavenger receptor in patients with coronary heart disease. METHODS: 75 patients with coronary heart disease (CHD), whose plasma lipid levels were normal, were divided into three groups: stable angina pectoris, unstable angina pectoris and acute myocardia infarction. 29 healthy persons were served as control. The level of C-reactive protein (CRP), soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) in plasma were determined in all subjects. Monocytes in peripheral blood were dissevered and cultured to transform into macrophage. The influence of atorvastatin on activity of scavenger receptor in macrophage was observed. RESULTS: The level of CRP, sICAM-1, sVCAM-1 and activity of scavenger receptor of macrophage in acute myocardia infarction group were higher than that in stable angina pectoris, unstable angina pectoris and control. Atorvastatin lowered the activity of scavenger receptor of macrophages derived from monocytes in patients with coronary heart disease. Activity of scavenger receptor of macrophages derived from monocytes in patients with coronary heart disease was correlated positively with CRP, sICAM-1 and sVCAM-1. CONCLUSION: Activity of scavenger receptor may be taken as index for monitoring the degree of active vulnerable atherosclerosis plaque. Atorvastatin may inhibit activity of scavenger receptor in macrophages derived from monocytes in patients with coronary heart disease.
2.Mediating effect and masking effect of creative self-efficacy on emotion regulation and procrastination behavior of nursing undergraduates
Meng ZHANG ; Annuo LIU ; Wen MA ; Cuilu DING ; Guiyue ZHU ; Guohong CHEN
Chinese Journal of Modern Nursing 2021;27(5):685-690
Objective:To explore the mediating effect and masking effect of creative self-efficacy on emotion regulation and procrastination behavior of nursing undergraduates, to provide a reference for the cultivation of creative self-efficacy of nursing undergraduates and improvement of their competence in innovative tasks.Methods:From May to June 2018, a total of 550 nursing undergraduates from a medical university in Hefei were surveyed by cluster sampling method, using general data questionnaire, Emotion Regulation Questionnaire, Creative Self-efficacy Scale for College Students and General Procrastination Scale. A total of 550 questionnaires were issued in this study and 509 valid questionnaires were finally recovered, with an effective recovery rate of 92.55%.Results:The procrastination behavior of nursing undergraduates was negatively correlated with emotion regulation and cognitive reappraisal ( P<0.01) , and positively correlated with expression suppression ( P<0.01) . Procrastination behavior was negatively correlated with creative efficacy and its dimensions ( P<0.01) . Emotion regulation and its dimensions were positively correlated with creative efficacy ( P<0.01) . The creative efficacy of nursing undergraduates played a part of the mediating role between cognitive reappraisal and procrastination behavior, and the indirect effect of creative self-efficacy between expression suppression and procrastination behavior was shown as a masking effect. Conclusions:Cognitive reappraisal or expression suppression can indirectly affect procrastination behavior through creative self-efficacy. Nursing educators can enhance students' innovation efficacy by increasing the self-recognition of nursing students and opening innovative training courses online or offline.
3.Mediating effect of positive psychological capital on achievement motivation and procrastination behavior of nursing undergraduates
Wen MA ; Annuo LIU ; Meng ZHANG ; Cuilu DING ; Guiyue ZHU ; Guohong CHEN
Chinese Journal of Modern Nursing 2021;27(8):1110-1115
Objective:To explore the mediating effect of positive psychological capital on achievement motivation and procrastination behavior of nursing undergraduates and the moderating effect of positive perfectionism on mediation.Methods:Using the cluster sampling method, a total of 550 nursing undergraduates from the 1st to 4th grades of School of Nursing of a medical university were selected as research objects from May to June 2018. General information questionnaire, Achievement Motivation Scale (AMS) , Positive Psychological Capital Questionnaire (PPQ) , positive perfectionism dimension of Frost Multidimensional Perfectionism Scale and General Procrastination Scale (GPS) were used for investigation. PROCESS software was used for moderated mediation effect analysis.Results:A total of 550 questionnaires were issued and 509 valid questionnaires were finally recovered, with an effective recovery rate of 92.55%. The GPS score of 509 nursing undergraduates was (55.08±8.18) , AMS score was (-0.03±6.02) , PPQ score was (4.35±0.70) and score of positive perfectionism dimension was (17.26±4.69) . Achievement motivation, positive psychological capital and positive perfectionism were all negatively correlated with procrastination behavior ( r=-0.245, -0.415, -0.357; P<0.01) . Positive psychological capital played a partial mediating role between achievement motivation and procrastination behavior, and the mediating effect accounted for 42.31% of the total effect. Positive perfectionism had a moderating effect on the second half of the mediating pathway of positive psychological capital ( P< 0.05) . Conclusions:The procrastination behavior of nursing undergraduates is at the middle level. Achievement motivation can influence procrastination behavior through positive psychological capital and positive perfectionism regulates the relationship between positive psychological capital and procrastination behavior.