Objective To investigate the clinical effect of budesonide inhalation in the treatment of children with pneumonia.Methods 100 children with pneumonia were randomly divided into the two groups.The control group received conventional oral medication,the observation group was given Pulmicort Turbuhaler (budesonide)inhalation therapy.The clinical efficacy and respiratory function changes were observed after treatment for 1 week.Results In the observation group,cough,shortness of breath,body temperature stable,pulmonary rales disappearance,X-ray absorption of inflammation and the average healing time were (1.28 ± 1.04) d,(2.48 ± 0.39) d,(2.04 ± 0.22) d,(2.22 ± 0.43) d,(3.39 ± 0.35) d,(3.65 ± 0.39) d,which were significantly better than those in the control group [(2.62 ± 1.63)d,(4.85 ± 1.38)d,(4.85 ± 1.31)d,(4.63 ±0.84)d,(5.53 ±0.82)d,(5.58 ±1.20) d(t =2.62,1.86,3.72,1.46,1.68,2.71,all P ＜0.05].In the observation group,the FEV1,PEF,FEF50％,FVC before treatment were (70.24 ± 10.46) L,(70.05 ± 12.86)L/s,(66.74 ± 11.77) ％,(67.16 ± 11.98) ％,after treatment were (90.14 ± 12.63) L,(92.64 ± 10.75) L/s,(84.56 ± 15.12) ％,(81.65 ± 13.96) ％,after treatment the indicators were significantly improved (t =2.34,4.83,1.89,3.27,all P ＜ 0.05).In the control group,before treatment,the FEV1,PEF,FEF50％,FVC were (70.56 ±9.95) L,(70.17 ± 13.58) L/s,(66.45 ± 11.58)％,(67.44 ± 12.37) ％,after treatment were (78.76 ± 11.44) L,(79.46 ± 14.36) L/s,(70.24 ± 12.39) ％,(72.03 ± 12.47) ％,after treatment all indicators were significantly improved (t =3.15,2.67,4.16,2.34,all P ＜ 0.05).The improvement of lung function in the observation group was significantly better than the control group (t =2.64,2.85,1.58,2.72,P ＜ 0.05).The effective rate of the observation group was 92％,which was significantly higher than 72％ of the control group (x2 =6.7 5 5,P ＜ 0.0 5).Conclusion Pulmicort Turbuhaler inhalation in the treatment of children with pneumonia can significantly relieve airway hyperresponsiveness,improve treatment effect,improve respiratory function.

Cancer cachexia(CC)caused by cancer is a syndrome with complicated symptoms.Traditional therapies usually give interventions for more nutrition intake at CC late stage and take weight as the outcome marker.Lots of clinical trials demonstrate that the effect is not satisfactory.Recent studies show that the level of NF-KB decreased,termination of the breakdown of myofibrillar proteins,the serum proteins and lean body mass increased and function improvement after targeting proteasome at early stage of CC combined with traditional therapy.

Conspecific organ transplantation provides the survival for the diseased patients at the later stage. The transplantation-induced emotional disorder, rejection, social and psychological burdens all affect the donor, recipients and their relatives, together with the involved medical staff regarding the physical and mental health. The differences of gender, age, cultural background, economic status, social and family roles, and religion beliefs may result in the varying psychological reactions. Therefore, it is recommended to conduct the psychological intervention for the population at each stage of the organ transplantation, as the transplantation technique increases.

Cytokine-induced killer (CIK) cells therapy plays an important role in cancer adjuvant treatment.Researches show that the number of peripheral blood immunocytes will change if patients with cancer accept the treatment of CIK cells.The changes of T cell subsets,regulatory T cells are relatively obvious,which may be one of the standards that can evaluate the curative effect of CIK cells.

Objective To investigate the necessity of releasing the distal holdfast fibers of the flexor retinaculum(DHFFR) during endoscopic carpal tunnel release(ECTR).Methods The Experiment Group included 16 cases.The operation was conducted under brachial plexus anesthesia without the use of tourniquet.A 1 cm skin incision was made.The USE system(Universal Subcutaneous Endoscope System) was employed.Both flexor retinaculum(FR) and distal holdfast fibers of the flexor retinaculum were cut off.Postoperative outcomes were compared with another 16 cases of flexor retinaculum release only(Control Group).Results Follow-up evaluation was carried out at 6 postoperative months.According to the Kelly's criteria,there were 13 cases of excellent results and 3 cases of good results in the Experiment Group,and 8 cases of excellent,5 cases of good,and 3 cases of fair results in the Control Group.Significant difference was obser red in flameda Ⅱ or Ⅲ grade patients between the two groups in carative effects(?~2=6.278,P=0.043).No serious complications or postoperative recurrence occurred.Conclusions Flexor retinaculum is not the only structure existing in the carpal canal to be released.More attention should be paid to complete decompression of both flexor retinaculum and distal holdfast fibers of the flexor retinaculum,especially in those who have serious symptoms.

Objective To evaluate the endoscopic tendon sheath release for stenosing tenovaginitis (trigger finger). Methods Five patients with stenosing tenovaginitis (2 in thumbs, 1 in middle finger, and 2 in ring fingers) underwent operations by Smith & Nephew Endoscopic Trigger Finger Release system. After two 3.0mm transverse incisions were made, the window cannula assembly was inserted subcutaneously along the sheath from the proximal portal and advanced until it passed through the distal portal. Then a 2.7 mm endoscope was passed into from the proximal portal and a retrograde knife was introduced into the operative site from the distal portal. Finally the entire length of sheath was sectioned under direct endoscopic vision. Results All operations were successfully completed. Finger's flexion and extension function recovered immediately after the operations. All the patients restarted their employment one week postoperatively. There were no complications such as distinct pain or delayed wound healing in these patients. Conclusions This method has the advantages of minimal invasion, safety, effectiveness and quick recovery, especially suited to diabetic patients or multiple trigger fingers.

Poly ( aniline_luminol ) composite nanowires were synthesized by chemical oxidation using ammonium peroxydisulfate. In contrast to the maximum fluorescence emitting wavelength of luminol at 425 nm, the maximum fluorescence emitting wavelength of the polymeric luminol in the composite nanowires was red shifted to 465 nm obviously. The poly ( aniline_luminol) composite nanowires were modified on graphite electrode surface by drop coating, forming a stable poly ( aniline_luminol ) composite nanowires film. The composite nanowires film modified electrode presented favorable electrochemiluminescence ( ECL ) performances, and the ECL response could be enhanced by hydrogen peroxide. Under the optimized experimental conditions, the modified electrode provided a linear range of 5. 0×10-9-1. 0×10-5 mol/L for the detection of hydrogen peroxide with a detection limit of 2 ×10-9 mol/L.

Standardized patient(SP) is playing an important role in medical education.Nevertheless this kind of medical education is not perfect.By use of analyzing the shortcomings in internal medicine education by SP.the effect of SP education will be greatly increased.

Objective To obtain the comprehensive information of the normal peroneal nerve by high resolution ultrasonography.Methods The cross-sectional area was measured by observing the traveling law of peroneal nerve as well as its ultrasonographic features,choosing the polyline level of popliteal and the peroneal nerve around the fibular neck as measurement point.Results There was no significance on statistics in differences of the above-mentioned cross-sectional area.The overall mean of its peroneal nerve were (0.139 ± 0.043)cm2 and (0.114 ± 0.032)cm2 resectively; and its peroneal nerve among men seems a little bit wider than that among women,the old wider than the youth.It was positively correlated with height and weight(r =0.569,0.625,respectively,both P ＜0.05).Conclusions The high-resolution ultrasound can show the form and shape of the peroneal nerve,thus providing diagnostic criteria in quantity by measuring its normal cross-sectional area.

Inrecentyearsmanytargetedagentstreatinggastriccancerhavebeenevaluatedinclinical studies.Trastuzumab,an anti-HER-2 monoclonal antibody,has shown activity against HER-2-positive gastric cancer and become the first targeted agent approved in gastric cancer.Drugs targeting epidermal growth factor receptor,including monoclonal antibody and tyrosine kinase inhibitor,bring survival benefit to patients with gastric cancer.Addi tionally,vascular endothelial growth factor inhibitors are also under investigation.Other targeted agents are in preclinical or early clinical development,such as m-TOR inhibitors and c-MET inhibi-tors.