1.Clinical curative effect of budesonide inhalation in the treatment of children with Pneumonia
Chinese Journal of Primary Medicine and Pharmacy 2015;22(2):181-183
Objective To investigate the clinical effect of budesonide inhalation in the treatment of children with pneumonia.Methods 100 children with pneumonia were randomly divided into the two groups.The control group received conventional oral medication,the observation group was given Pulmicort Turbuhaler (budesonide)inhalation therapy.The clinical efficacy and respiratory function changes were observed after treatment for 1 week.Results In the observation group,cough,shortness of breath,body temperature stable,pulmonary rales disappearance,X-ray absorption of inflammation and the average healing time were (1.28 ± 1.04) d,(2.48 ± 0.39) d,(2.04 ± 0.22) d,(2.22 ± 0.43) d,(3.39 ± 0.35) d,(3.65 ± 0.39) d,which were significantly better than those in the control group [(2.62 ± 1.63)d,(4.85 ± 1.38)d,(4.85 ± 1.31)d,(4.63 ±0.84)d,(5.53 ±0.82)d,(5.58 ±1.20) d(t =2.62,1.86,3.72,1.46,1.68,2.71,all P <0.05].In the observation group,the FEV1,PEF,FEF50%,FVC before treatment were (70.24 ± 10.46) L,(70.05 ± 12.86)L/s,(66.74 ± 11.77) %,(67.16 ± 11.98) %,after treatment were (90.14 ± 12.63) L,(92.64 ± 10.75) L/s,(84.56 ± 15.12) %,(81.65 ± 13.96) %,after treatment the indicators were significantly improved (t =2.34,4.83,1.89,3.27,all P < 0.05).In the control group,before treatment,the FEV1,PEF,FEF50%,FVC were (70.56 ±9.95) L,(70.17 ± 13.58) L/s,(66.45 ± 11.58)%,(67.44 ± 12.37) %,after treatment were (78.76 ± 11.44) L,(79.46 ± 14.36) L/s,(70.24 ± 12.39) %,(72.03 ± 12.47) %,after treatment all indicators were significantly improved (t =3.15,2.67,4.16,2.34,all P < 0.05).The improvement of lung function in the observation group was significantly better than the control group (t =2.64,2.85,1.58,2.72,P < 0.05).The effective rate of the observation group was 92%,which was significantly higher than 72% of the control group (x2 =6.7 5 5,P < 0.0 5).Conclusion Pulmicort Turbuhaler inhalation in the treatment of children with pneumonia can significantly relieve airway hyperresponsiveness,improve treatment effect,improve respiratory function.
2.Cancer cachexia diagnosis and therapy
Journal of International Oncology 2012;39(7):510-513
Cancer cachexia(CC)caused by cancer is a syndrome with complicated symptoms.Traditional therapies usually give interventions for more nutrition intake at CC late stage and take weight as the outcome marker.Lots of clinical trials demonstrate that the effect is not satisfactory.Recent studies show that the level of NF-KB decreased,termination of the breakdown of myofibrillar proteins,the serum proteins and lean body mass increased and function improvement after targeting proteasome at early stage of CC combined with traditional therapy.
3.Psychological issues after organ transplantation
Chinese Journal of Tissue Engineering Research 2007;0(31):-
Conspecific organ transplantation provides the survival for the diseased patients at the later stage. The transplantation-induced emotional disorder, rejection, social and psychological burdens all affect the donor, recipients and their relatives, together with the involved medical staff regarding the physical and mental health. The differences of gender, age, cultural background, economic status, social and family roles, and religion beliefs may result in the varying psychological reactions. Therefore, it is recommended to conduct the psychological intervention for the population at each stage of the organ transplantation, as the transplantation technique increases.
4.Assessment of CIK cells in adoptive cellular therapy
Wenhao WANG ; Guixin LI ; Jin LIU
Journal of International Oncology 2013;(2):106-108
Cytokine-induced killer (CIK) cells therapy plays an important role in cancer adjuvant treatment.Researches show that the number of peripheral blood immunocytes will change if patients with cancer accept the treatment of CIK cells.The changes of T cell subsets,regulatory T cells are relatively obvious,which may be one of the standards that can evaluate the curative effect of CIK cells.
5.Electrochemiluminescence Performance of Poly(aniline_luminol) Composite Nanowires Synthesized by Chemical Oxidation
Yanjie WANG ; Guixin LI ; Xingwang ZHENG
Chinese Journal of Analytical Chemistry 2015;(1):141-145
Poly ( aniline_luminol ) composite nanowires were synthesized by chemical oxidation using ammonium peroxydisulfate. In contrast to the maximum fluorescence emitting wavelength of luminol at 425 nm, the maximum fluorescence emitting wavelength of the polymeric luminol in the composite nanowires was red shifted to 465 nm obviously. The poly ( aniline_luminol) composite nanowires were modified on graphite electrode surface by drop coating, forming a stable poly ( aniline_luminol ) composite nanowires film. The composite nanowires film modified electrode presented favorable electrochemiluminescence ( ECL ) performances, and the ECL response could be enhanced by hydrogen peroxide. Under the optimized experimental conditions, the modified electrode provided a linear range of 5. 0×10-9-1. 0×10-5 mol/L for the detection of hydrogen peroxide with a detection limit of 2 ×10-9 mol/L.
6.Endoscopic release of distal holdfast fibers of the flexor retinaculum for carpal tunnel syndrome
Guixin SUN ; Qilin SHI ; Wenjun LI
Chinese Journal of Minimally Invasive Surgery 2005;0(07):-
Objective To investigate the necessity of releasing the distal holdfast fibers of the flexor retinaculum(DHFFR) during endoscopic carpal tunnel release(ECTR).Methods The Experiment Group included 16 cases.The operation was conducted under brachial plexus anesthesia without the use of tourniquet.A 1 cm skin incision was made.The USE system(Universal Subcutaneous Endoscope System) was employed.Both flexor retinaculum(FR) and distal holdfast fibers of the flexor retinaculum were cut off.Postoperative outcomes were compared with another 16 cases of flexor retinaculum release only(Control Group).Results Follow-up evaluation was carried out at 6 postoperative months.According to the Kelly's criteria,there were 13 cases of excellent results and 3 cases of good results in the Experiment Group,and 8 cases of excellent,5 cases of good,and 3 cases of fair results in the Control Group.Significant difference was obser red in flameda Ⅱ or Ⅲ grade patients between the two groups in carative effects(?~2=6.278,P=0.043).No serious complications or postoperative recurrence occurred.Conclusions Flexor retinaculum is not the only structure existing in the carpal canal to be released.More attention should be paid to complete decompression of both flexor retinaculum and distal holdfast fibers of the flexor retinaculum,especially in those who have serious symptoms.
7.Endoscopic tendon sheath release for stenosing tenovaginitis: A preliminary report
Wenjun LI ; Qilin SHI ; Guixin SUN
Chinese Journal of Minimally Invasive Surgery 2001;0(04):-
Objective To evaluate the endoscopic tendon sheath release for stenosing tenovaginitis (trigger finger). Methods Five patients with stenosing tenovaginitis (2 in thumbs, 1 in middle finger, and 2 in ring fingers) underwent operations by Smith & Nephew Endoscopic Trigger Finger Release system. After two 3.0mm transverse incisions were made, the window cannula assembly was inserted subcutaneously along the sheath from the proximal portal and advanced until it passed through the distal portal. Then a 2.7 mm endoscope was passed into from the proximal portal and a retrograde knife was introduced into the operative site from the distal portal. Finally the entire length of sheath was sectioned under direct endoscopic vision. Results All operations were successfully completed. Finger's flexion and extension function recovered immediately after the operations. All the patients restarted their employment one week postoperatively. There were no complications such as distinct pain or delayed wound healing in these patients. Conclusions This method has the advantages of minimal invasion, safety, effectiveness and quick recovery, especially suited to diabetic patients or multiple trigger fingers.
8.The shortcomings and the solution in internal medicine education by standardized patient
Zhong LU ; Li QI ; Guixin LI ; Jinping YANG
Chinese Journal of Medical Education Research 2005;0(05):-
Standardized patient(SP) is playing an important role in medical education.Nevertheless this kind of medical education is not perfect.By use of analyzing the shortcomings in internal medicine education by SP.the effect of SP education will be greatly increased.
9.Circulating tumor cell detection technology and its appfication in non-small cell lung cancer
Dianxia GONG ; Guixin LI ; Zhong LU ; Wenhao WANG
Journal of International Oncology 2013;40(10):769-771
As a useful supplement for TNM staging system of non-small cell lung cancer (NSCLC),circulating tumor cell (CTC) can better reflect the comprehensive condition of the patient.CTC plays an important potential role in monitoring curative effect of lung cancer,and has the effect of real-time detection.With the development of the CTC detection method and the improvement of sensitivity and specificity,clinical studies about CTC will provide more help for prognosis evaluation.
10.Treatment of olecranon fracture with biodegradable tension band in 9 cases
Xin WEI ; Guixin SUN ; Lijun LI ; Jun TAN
Chinese Journal of Tissue Engineering Research 2010;14(8):1495-1498
BACKGROUND: Internal fixations with plate and screw or K-wira tension band are widely used in treating olecranon fracture; however, the internal fixations need to remove by a second surgery. OBJECTIVE: To retrospective analyze the therapeutic effect of treating olecranon fracture using biodegradable tension band. METHODS: Nine olecranon fracture patients received at the Shanghai East Hospital of Tongji University from July 2006 to April 2009 were selected. All patients were treated by biodegradable tension band fixation which comprises absorbable screw and absorbable suture. Elbow joint functional exercises were performed at 3 weeks after plaster extema! fixation. The patients were followed up for 12 months, and the therapeutic effect was measured by X-ray films and Mayo score of elbow joint function. RESULTS AND CONCLUSION: Imaging examination showed that the fracture healing well in all cases, and the fracture line was blurred. No ulnar nerve compression, fracture, or fracture displacement could be seen. Biodegradable tension band fixation can provide adequate intensity for functional exercises, which has the virtue of effective fixation without a second surgery to remove fixation. It is believed to be a good method for the treatment of olecranon fractures.