The growth of brain metastasis needs appropriate microenvironment, and the change of normal brain microenvironment is the basis for exploring metastasis with MRI. Through the local magnetic field changes and the application of contrast agents for improving the discrepancy of the cerebral tissue, MR can accurately detect brain metastasis in position, number, size, and shape. MR with contrast-enhanced technique is the first choice for screening brain metastasis. The application of all kinds of new MR techniques, sequences and intracellular contrast agents can not only further improve the specificity of detection, but also improve the sensitivity of MRI, which is favorable to formulating reasonable treatment and prolonging the lifetime of the patients. The microenvironment of brain metastasis and advances in the new MR techniques were reviewed in this article.

In the treatment of 34 cases of radial nerve paralysisby puncturing the acupoints in Yangming meridians of the hand and foot, plus TDP radiation in the local areas after acupuncture, the total effective rate is 97.1%.

Objective To analyse the detective rate and significance in diagnosis of cerebral and meningeal metastases by MR.Methods 115 cases with cerebral and meningeal metastasis were proved by operation and pathology.There were male 86 and females 29 ranged in age from 17-77 years old,plain MR scan and enhanced MR scan were performed in all cases.Results In this group included 46 cerebral metastases(40.0%),33 meningeal metastasis(28.7%),36 both cerebral and meningeal metastases(31.3%). Different degree of enhancement was showed on enhanced MRI in all cases, "mouse tail signs"or"target signs" were appeared in which cerebral metastasis with the adjoining meninges involved.Conclusion MRI is a good method for diagnosing cerebral and meningeal metastasis.Enhanced MRI has an important value.

OBJECTIVE: To discuss the diagnosis and treatment of esophageal perforation induced by esophageal foreign body. METHOD: Ten patients, who were diagnosed as esophageal foreign body and esophageal perforation, were retrospectively analyzed. One patient was operated in other hospital and transferred to our department post-operation. The foreign bodies were removed through rigid esophagoscope in 7 cases and through the tracheotomy in 1 case. The last case was admitted into hospital for abscess around the esophagus. The foreign body wasn't find during the examination of rigid esophagoscope and the patient vomited out a glass foreign body after the surgery. RESULT: In all cases, there were three date stones, two button batteries, one metal gear, one pin, one metal cans pull ring, one glass plate, one arc hard plastic sheet. Seven patients were cured after conservative treatment, and restored normal diet. For the rest 3 cases, patients were cured after the repair operation of tracheoesophageal fistula. CONCLUSION The esophageal perforation must be highly suspected of the esophageal foreign body with a long history, sharp shape or corrosive foreign body. The esophageal radiography may be taken to obtain the final diagnosis. The patients diagnosed as esophageal perforation must be treated with antibiotics, nasal feeding or feeding by gastrostomy, and followed-up closely. Small perforation can heal after a period of time by nasal feeding, while tracheoesophageal fistula was needed to repaire after a period of time for restoring a good physical condition in most cases.
Abscess ; Child ; Esophageal Perforation ; diagnosis ; surgery ; Foreign Bodies ; diagnosis ; surgery ; Humans ; Retrospective Studies ; Tracheoesophageal Fistula ; Tracheotomy

Objective To explore the clinical efficacy of Ebastine joint Compound Glycyrrhizin in treatment of acute and chronic urticarial, and its effect on serum IgE levels.Methods Eighty cases of a-cute and chronic urticaria patients were collected from January 2010 to June 2014 in our hospital for treat-ment.They were randomly divided into control group and observation group, 40 cases in each group, the patients in the control group oral ebastine 10mg 1 times /day, patients in the observation group were given Compound Glycyrrhizin on 75mg and oral ebastine 10mg, 1 times /d, acute urticaria patients were treated for one week of continuous treatment, patients with chronic urticaria were treated for 4 weeks in a row;IgE level was measured by ELISA.Results After treatment, effective rate of patients with acute urticaria was 94.44%in the observation group, the control group was 68.42%; patients with chronic urticaria observa-tion group was 95.45%, the control group was 71.43%, a significant difference ( P <0.05 ) between the observation group and control group.IgE levels in both groups after treatment were reduced compared with before treatment ( P <0.01), after treatment IgE levels of patients had higher degree of improvement in the observation group, differences were statistically significant ( P <0.05).Conclusions The clinical effica-cy of ebastine joint Compound Glycyrrhizin on treatment of acute and chronic urticaria are better than single ebastine, two drugs used in conjunction with synergistic effect by regulating the body's immune function, re-duce allergy strength, improve efficacy.

Objective To investigate the effect of clinical pathway on patients with tubal pregnancy under-went laparoscopic treatment .Methods 150 patients with tubal pregnancy undergoing laparoscopic treatment were randomly divided into pathway group and control group , 75 patients in each .The patients in the pathway group were given clinical pathway management , whilepatients in the control group were given conventional management .The in-dexes, such as patients'average hospitalization time, average treatment cost, satisfaction, and the rate of health knowl-edge awareness of the two groups were compared .Results The average hospitalization time and the average treat-ment costof the pathway group were significantly shorter and lower than those of the control group , with statisticalsig-nificance (p<0.05), and the rate of satisfaction and health knowledge awareness of the pathway group were signifi -cantly higher than those of the control group (p<0.05).Conclusion The clinical pathway in patients with tubal pregnancy treated with laparoscopyis worth to popularize in clinical application , because it may effectively shorten the hospitalization time , reduce the treatment cost and improve the rate of satisfaction and health knowledge awareness .

Objective: To study the quality of life (QOL) and its influencing factors of elderly hospitalized terminal patients. Methods: The scale of Life Quality, Social Support Inventory, Life Satisfaction Index A(LSIA), Hospital Anxiety and Depression Scale(HAD), degree of pain (Verbal Report Scale, VRS) and Activities of Daily Living(ADL) were administered in 152 elderly hospitalized terminal patients. Results: 1)The total score of each scale was QOL 36.9?7.4, ADL56.27?34.5,Social Support 40.0?6.3, HAD(A)8.9?4.1,HAD(D)11.2?4.9,LSIA 11.6?3.9?2)Pearson's correlation showed that QOL scores were negatively correlated with degree of pain (r=-0.54,P

0.05). But according to the data, IL-8 in Qingqinye low dosage group was lower than model group, positive medicine group, Qingqinye high dosage group and Qingqinye middle dosage group. TNF-? in Qingqinye group was lower than model group and positive medicine group, especially in Qingqinye middle dosage group. Pathological section with articular cavity and surrounding tissues were better in positive medicine group and Qingqinye group. Conclusion Qingqinye has a certain effect for repairing joint immune pathological injury in hyperuricemia model rats.

Objective: To study the anti-tumor effect of recombinant human MUC1-MBP. Methods: The C57BL/6 mice were in oculated with MUC1-MBP by subcutaneous. MUC1 specific CTL activity of spleen were determined by MTT; The effects on prevention and treatment of tumor were observed by establishing lewis lung cancer-carrying mice. Results: The cytotoxicity of CTL from immunized mice to the MCF7 and Lewis lung cancer cells respectively was (47.7?4.3) % and (67.5 ?6.5) %; 5?10 5 lewis lung cancer cells following immunization were injected iv into C57BL/6 mice, after three weeks, the number of lung and tail tumor colonies was 51 and 5 for PBS and MUC1-MBP groups respectively and the suvival time was significantly delayed in immunized mice. The average volume of tumors in mice with MUC1-MBP was 386 mm 3 wherea control group was 4 000 mm 3 at tumor treating experiment. Conclusions: Recombinant human MUC1-MBP have significantly effects on prevention, treatment and inhibiting metastases of tumor. Our results suggested that the recombinant MUC1-MBP might be used to develop protein vaccine against human carcinoma.

Objective To develop a method for the determination of four saponins of panax notoginseng in Compound Dan-shen Prescription (CDP) by HPLC. Methods The conditions for the experiment were: determination of notoginsenoside R1, ginsenoside Rg1 and ginsenoside Re with acetonitrile - 0. 05 % phosphoric acid (19 : 81) as mobile phase and the detection wave at 203nm, determination of ginsenoside Rb1 with acetonitrile - water (33 : 67) as mobile phase and the detection wave at 203nm. Results A good linearity for notoginsenoside R1 was in the range of 0. 24 ~ 3. 6?g ( r = 0. 9997), 1. 2 ~ 18?g (r = 0. 9994) for ginsenoside Rg1, 0. 08 ~ 1. 2?g(r = 0. 9997) for ginsenoside Re and 0. 25-3. 72?g (r = 0. 9998) for ginsenoside Rb1. The stability of the four saponins is well kept at 4℃ for four months. Conclusion This method is simple, rapid, accurate and with good reproducibility and can be used for the quality control of CDP.