1.A randomized controlled study of peramivir, oseltamivir and placebo in patients with mild influenza
Hongwei FAN ; Yang HAN ; Wei LIU ; Xingwang LI ; Lizhong LI ; Heyun YAO ; Yong WANG ; Zhiqiang SU ; Weixian YE ; Jin HUANG ; Weizhong LU ; Guiwei LI ; Hailing LI ; Shaoyang WANG ; Hao WU ; Qiaofa LU ; Guangfa ZHU ; Shengming LIU ; Gang CHEN ; Wenhong ZHANG ; Taisheng LI
Chinese Journal of Internal Medicine 2019;58(8):560-565
Objectives To evaluate the effectiveness and safety of peramivir trihydrate in patients with influenza.Methods This was a randomized,double-blind,double-dummy,placebo and positive control,multicenter clinical trial,comparing peramivir trihydrate with oseltamivir and placebo.The inclusive criteria were 15-70 years old,onset within 48 h,positive rapid influenza antigen test,and febrile(>38℃) accompanied with at least two associated symptoms.The severe cases complicated with chronic pulmonary and cardiac diseases,malignancies,organ transplantation,hemodialysis,uncontrolled diabetes,immunocompromised status,pregnancy and coexistence of bacterium infections were excluded.All patients were randomized 2:2:1 to receive peramivir,oseltamivir and placebo respectively.The primary endpoint was the disease duration,the secondary endpoints included time to normal axillary temperature and normal living activities,viral response,and adverse effects.Results Following informed consent,133 patients were included in this study.Four patients were exclude due to missing medical records,not fitting inclusion or exclusion criteria and poor compliance.A total of 129 patients were finally analyzed,including 49 cases,54 cases and 26 cases in peramivir group,oseltamivir group and placebo group.The median disease duration were 96 (76,120)hours,105(90,124) hours,and 124 (104,172)hours in three groups respectively(P>0.05).The time to normal axillary temperature,normal living activities and viral response were not significantly different in three groups(P>0.05).Conclusion The value of antiviral therapy in patients with mild influenza needs to be further determined.
2.Epidemiological study on hookworm infection in rural population in Tiantai County, Zhejiang Province in 2022
Junhua GE ; Jiang CHU ; Guiwei ZHU ; Binbin DING ; Caixia PANG ; Saifei LUO ; Tianlan PANG ; Wei RUAN
Shanghai Journal of Preventive Medicine 2024;36(4):364-367
ObjectiveTo understand the prevalence of hookworm infection and its relevant behavioral factors in rural areas of Tiantai County, Zhejiang Province, and to provide scientific evidence for prevention and control of hookworm disease. MethodsBy using a stratified cluster random sampling strategy, local residents aged ≥3 years was divided into 5 districts according to geographical location; furthermore, those in one administrative village (surveillance site) were investigated in each district. Species of hookworm were identified by filter paper culture in vitro, and enterobius vermicularis eggs were detected by cellophane anal swab in children aged 3‒9 year. Risk factors were determined by questionnaire. ResultsA total of 1 013 residents were investigated in 5 surveillance sites. Thirty nine cases with hookworm infection were detected, with the total infection rate of 3.85% . All species detected were determined to be Necator americanus. The infection rate significantly differed across the towns (χ2=48.32, P<0.05), with the highest rate in Nanping Town (10.95%) . It significantly differed by age groups (χ2=65.65, P<0.05), with the highest rate in those aged >70 years (9.75%). Furthermore, it decreased with educational background. It was significantly associated with fertilize with fresh manure (χ2=6.87, P<0.05) and barefoot labor (χ2=157.69, P<0.05). ConclusionThe overall infection rate of hookworm in Tiantai County remains low. Dominant species of hookworm is hookworm Necator americanus. It is necessary to strengthen the advocacy of hookworm prevention and control knowledge, improve hygiene in work and life style, and increase self-protection awareness.