BACKGROUND:The elderly hip fracture patients with chronic obstructive pulmonary disease (COPD) have a higher postoperative mortality than those only with hip fractures. In recent years, it has become an issue of concerns. Because the mechanism is unknown, however, there are no effective clinical interventions for these patients. OBJECTIVE:To observe the effect of bone marrow stromal stem cel s (BMSCs) on the level of pulmonary inflammation in aged rats with chronic obstructive pulmonary disease (COPD) after hip fractures. METHODS:Thirty male Sprague-Dawley rats, 12 months old, were exposed to smoking for 4 months and randomized into three groups, smoking, smoking+hip fracture+normal saline, smoking+hip fracture+BMSCs groups. Animal models of hip fracture were made in the latter two groups. Twenty-four hours after hip fracture, the lower lobe and peripheral blood samples were taken from al rats in the three groups, to evaluate the pathological changes of lung tissue and detect levels of inflammatory factors in the lung tissue and peripheral blood. RESULTS AND CONCLUSION:After closed hip fracture, aged COPD rats exhibited inflammatory cel infiltration, mucus secretion, airway stenosis or occlusion;the levels of interleukin-6, tumor necrosis factor-αand interleukin-10 in the lung tissue and peripheral blood were increased. After intravenous injection of BMSCs, the pathological changes of the lung tissue were reduced, and the levels of pro-inflammatory factors, tumor necrosis factor-αand interleukin-6, decreased, but the level of anti-inflammatory factor interleukin-10 further increased, which were significantly different from those in the normal saline group (P<0.05). These findings indicate that BMSCs can relieve acute lung injury in aged COPD rats with hip fractures.

OBJECTIVETo propose a square's ring motion stimulation based on steady-state motion visual evoked potential, and compare it with the commonly used visual stimulation modes (Newton's ring motion, square flicker and circular flicker).

METHODSEEG signals were collected while 9 experimental subjects gazing at four stimulation and pattern analyzed by Canonical Correlation Analysis (CCA). Stimulation were evaluated by recognition accuracy and subjective scores.

RESULTSThe classification accuracies of SSVEP elicited by the square's ring motion(82.8%±14.1%) and Newton's ring(83.3%±11.5%) have no significant difference between them, which are lower than that of the square flicker(98.3%±4.1%) and the circular flicker(99.2%±1.8%). The shape of the figure has no significant influence on the classification accuracy either in motion mode or flicker mode. The comfort of the square's ring motion is higher than the other three stimulation according to subjective scores.

CONCLUSIONSThe square's ring motion can elicit EEG and reduce the discomfort caused by flicker modes. The square's ring motion can be used as a visual stimulation in SSMVEP-based BCI system.