1.HLA-DRB1 genotyping and its relation with chronic hepatitis B p atients of Hanethnic in Shanxi Area with HBV infection
Guitao YANG ; Jie LIU ; Dezhong XU
Medical Journal of Chinese People's Liberation Army 2001;0(10):-
Objective To study the HLA-DRB1 genotype and their r elation with HBV infection among Han patients in shanxi area. Methods HLA-DRB1 genotyping was conducted in 54 patients HBV infection and 108 health controls, as well as 32 asymtomatic HBsAg carriers by using polymerase ch ain reaction/sequence specific primer (PCR-SSP) method. All the patients, asy mtomatic HBsAg carriers, and healthy subjects were inhabitants of Shan'xi area o f Han nationality. The association between HLA-DRB1 genotype and different repl ication of HBV were also studied. Results DRB1*04,DRB1*09,DRB 1*12, DRB1*15 were the most common genotypes in the Shan'xi Han inbabitants wit h the frequency of 16.2%,12.5%,11.6% and 13.4% respectively. Compared to 108 healthy controls, the allele frequency of HLA-DRB1*03 was 11.1% in HBV patien ts versus 3.7% in healthy controls, with odds ratio=3.57 and Pc=0.014 ( P
2.HLA-DRB1 genotyping and its relation with chronic HBV infection in patients
Guitao YANG ; Jie LIU ; Dezhong XU ; Yongping YAN ; Huahong XIE ; Yulei DU
Chinese Journal of Pathophysiology 1989;0(05):-
AIM: To study the HLA-DRB1 genotype and their relation with HBV infection in Shaanxi Han patients.METHODS: HLA-DRB1 genotyping was conducted in 108 case of chronic HBV infection and 108 health controls as well as 32 asymtomatic HBsAg carriers by using polymerase chain reaction-sequence specific primer method.All the patients,asymtomatic HBsAg carriers and health subjects were residents of Shaanxi district and belonged to Han nationality.The association between HLA-DRB1 genotype and different replication of HBV was also studied.RESULTS: DRB1~*04,DRB1~*09,DRB1~*12 and DRB1~*15 were the most common genotypes in Shaanxi Han residents with the frequency of 16.2%,12.5%,11.6% and 13.4%,respectively.Compared to 108 health controls,the allele frequency of HLA-DRB1~*03(10.6% of HBV patients versus 3.7% of health controls,odds ratio=3.10;P
3.Progress of the correlation of microRNA with diffuse large B-cell lymphoma and its treatment application
Peng LIU ; Yue XU ; Yanli WANG ; Li LI ; Guitao JIE
Journal of Leukemia & Lymphoma 2022;31(3):189-192
MicroRNA (miRNA) plays an important role in the development of diffuse large B-cell lymphoma (DLBCL) by binding to the 3′ non-coding region of the target gene mRNA to regulate gene expression after transcription. The expression level of miRNA is closely related to the clinical staging, typing, prognosis assessment, and therapeutic effect of DLBCL. miRNA has a great potential as that of DLBCL-related biomarkers, and because of the close link between the two, miRNA-based therapies are expected to lead to new treatment options for DLBCL patients.
4.Successful Heart Transplantation After Thrombectomy for Acute Ischemic Stroke in a Patient With Heart Failure Complicating With Acute Ischemic Stroke
Yao FENG ; Bincheng WANG ; Guitao ZHANG ; Xiaoying HU ; Ru LIU ; Sheng LIU ; Shujuan LI ; Jie HUANG
Chinese Circulation Journal 2024;39(3):290-293
It remains unclear whether heart transplantation is still feasible on patients who develop neurological complications before surgery and underwent successful neurological treatment.This article reported the diagnosis and treatment process of a heart failure patient complicating with acute ischemic stroke,who underwent successful heart transplantation after thrombectomy for acute ischemic stroke,aiming to provide clinical evidence and decision-making plan on diagnosis and treatment options for this group of patients with severe neurological complications.