The protective function of five traditional herb medicines, namely anisodamine,escin,salvia miltiorrhizae radix,astragalus root and ecdysterone, in cultured HUVECs challenged by LPS. ATP,ADP,AMP and energy charge were measured in cultured HUVECs challenged by LPS after treatment with five herb medicines. The results showed that energy charge of HUVECs decreased after LPS challenge,and increased significiantly more afer the addition of escin,radix astragali and ecdysterone than other herbs.It suggested that escin, astragalus and ecdysterone can protect HUVECs from injury induced by LPS.

Objective To discuss the diagnosis and management of metastatic adrenal carcinoma. Methods Forty-seven cases with metastatic tumor in the adrenal glands were analyzed retrospectively from December 1996 to April 2010. Lung was the most common primary tumor site (51.1 %, 24 cases), followed by the renal cell carcinoma (12.8%, 6 cases), liver cancer (10.6%,5 cases), breast cancer (8.5%, 4 cases), melanoma (4.2%, 2 cases), and other carcinoma (12.8%,6 cases). Most patients with metastatic adrenal carcinoma had no special clinic manifestation. Lesions of 36 cases were surgically removed and 11 cases gave up operation. Results The mean survival time were 33.8±4.5 months for 31 cases underwent adrenalectomy and 6.3±2.7 months for 6 cases without operation. Patients with surgically removed adrenal metastases had better survival than those without surgical resection. Conclusions Adrenal gland is a common site of metastatic carcinoma.Ultrasonographic and CT scans are important diagnosis methods for metastatic adrenal carcinoma. Operation is still effective and long-term survival may be achieved for those well selected patients, but surgical indication must be strictly monitored.

Objective To study the clinical effect and perioperative nursing of holmium laser lithotripsy under ureteroscope ( PCUL) in the treatment of isolated kidney stones. Methods A total of 32 patients with isolated kidney stones were selected and their calculus were removed by using PCUL and meticulous perioperative nursing. Operation time, bleeding volume and stone clearance rate were observed; renal function changes before and 2 weeks after surgery were compared; anxiety and depression psychological state and pain before and after nursing were assessed; adverse events before and after nursing were recorded. Results The mean operative time was (89.7±2.18) min;average bleeding volume was (22.8±0.95) mL;totally 30 patients with stone clearance and the clearance rate was 93.75%; The levels of blood urea nitrogen ( BUN) and serum creatinine (Scr) were significantly reduced 2 weeks after surgery ( P<0. 01); Creatinine ( Ccr) rate was decreased slightly; The scores of anxiety, depression and pain were significantly reduced after nursing ( P<0.01) . The cases of hematuria, back pain, bladder irritation and infections were significantly reduced. Conclusions PCUL is safe and effective for the treatment of isolated kidney stones with high stone clearance rate, and combined with meticulous perioperative nursing can significantly improve patients′ anxiety and depression;reduce the incidence of postoperative complications and adverse events, and promote early recovery. It′s worthy of clinical use.

Objective To investigate the Effect of minimally invasive percutaneous ureteroscopic holmium laser lithotripsyl ( PCUL) in perioperative nursing and treatment of kidney stones of elderly patients. Methods A total of 96 elderly patients with nephrolith were divided into the control group ( n=50) and the experimental group ( n=46). Patients in the experimental group were treated with PCUL and perioperative nursing, while patients in the control group were treated with PCNL and routine nursing. Related index in clinical treatment was observed and compared in two groups. Postoperative pains and anxieties were evaluated by visual analogue scale ( VAS) , verbal rating scale ( VRS) and self-rating anxiety scale ( SAS) , and the surgical complications were recorded. Results Compared with the control group, the blood loss, operative time, hospitalization time, duration of hematuria of patients in the observation group were all significantly lower ( P<0.05) . Before the operation, there was no significant difference in serum creatinine level between two groups;3 and 6 months after operation, the serum creatinine level of patients in the experimental group was significantly lower than that in the control group (P<0.01). The VAS score and SAS score in the observation group after operation were lower than that in the control group ( P<0.01) . The ratio of patients without pain or mild pain in the observation group was higher than that in the control group;the ratio of patients with moderate or severe pain or torturing was lower than that in the control group ( P<0. 05 ) . In addition, the complication rate of experimental group was 26.09%, which was significantly lower than that of control group with a complication rate of 46.00% (P<0.05). Stone clearance rate in the observation group was 93.48% (43/46);the incidence rate of complications was 26.09% (12/46), and they were all lower than that in the control group (78.00%,46.00%) (P<0.05).Conclusions The combination of PCUL and perioperative nursing had an exact clinical effect in the therapy of elderly patients with nephrolith, which could significantly improve renal function, release the anxiety condition, shorter operative time, decrease the trauma and postoperative complications with a higher safety. In a word, the use of PCUL in the therapy of elderly patients with nephrolith is worthy of clinical application.

Objective To investigate the effect of Plan-Do-Check-Action (PDCA) on postoperative psychological status and quality of life in patients with bladder cancer undergoing transurethral resection of bladder tumor (TURBT). Methods A total of 95 patients with non muscle invasive bladder cancer (NMIBC) undergoing TURBT hospitalized in Army General Hospital from November 2013 to November 2015 were selected and randomly divided into the control group (n=47) and the observation group (n=48). Patients in the control group received routine nursing care, while patients in the observation group received additional PDCA. The changes of serum norepinephrine (NE), epinephrine (E) and cortisol (Cor) levels were observed before and after the intervention in two groups. The SAS, SDS and the Self-esteem Scale (SES) were used to evaluate the psychological status of patients. The Simple Quality of Life Scale-36 (SF-36) was applied to evaluate the quality of life of patients. Results The postoperative serum NE, E and Cor levels of patients in the observation group were significantly lower than those in the control group (P< 0.01). At 1 month after the operation, SAS and SDS scores of patients in the observation group were lower than those in the control group, while SES score in the observation group was higher than that of the control group; there were statistically significant differences between two groups (P< 0.01). At 18 months after the operation, SF-36 score of patients in the observation group was significantly higher than that of the control group (P< 0.01). Conclusions PDCA can effectively reduce the postoperative stress reaction of bladder cancer patients after TURBT and improve their psychological status and quality of life, which is worthy of clinical promotion.

Objective To observe the effect of nursing intervention for urology surgery on postoperative pain.Methods A total of 120 patients treated by urologic surgical procedures in our hospital were averagely divided into control group and observation group according to the method of random digits table , each with 60 cases.The patients in control group were given usual care , while patients in observation group were given nursing intervention on the basis of usual care . The change of pain degree , using of analgesic drug , psychological status and degree of satisfaction of nursing care in both groups were observed and compared before and after nursing care .Results The pain degree of patients were alleviated in observation group , the difference was statistically significant (χ2 =12.29,P<0.05).The numbers of patients using analgesic drug were 31 cases (51.7%),control group with 43 cases (71.7%), the difference was statistically significant (χ2 =8.46,P<0.05).The psychological status and of nursing care were improved significantly in observation group after nursing intervention compared with control group , the difference was statistically significant (χ2 =15.15,P<0.05).The degree of satisfaction in observation group was 93.3%, the control group with 73.3%, the difference was statistically significant (χ2 =14.38,P<0.05).Conclusions Nursing intervention for urology of postoperative pain has good clinical effect and worth to application wildly in clinic .

Objective To explore the effects of comfort nursing interventions on clinical effects and negative emotions in patients receiving transurethral plasmakinetic resection of the prostate(PKRP).Methods A total of 94 patients with benign prostatic hyperplasia(BPH)were selected and randomized into a control group(n=47)and an observation group(n=47)from May 2013 to June 2015.All the patients received PKRP.Patients in the control group received conventional nursing care,while patients in the observation group received perioperative comfort nursing interventions in addition to conventional nursing.The changes in the patients' blood pressure and heart rate were detected;SAS and SDS were used to evaluate their anxiety and depression levels post operation;relevant clinical indicators were measured and compared between the two groups to evaluate their short-and long-term clinical effects;and the incidence of complications and satisfaction were compared between the two groups.Results Compared with control group,the systolic pressure,diastolic pressure,average arterial pressure and heart rate of the oberservation group were lower,and SAS and SDS scores in the patients of the oberservation group were lower postoperatively(P < 0.05).The time of bladder irrigation,catheter indwelling,operation and hospital stay was shortened in the patients in the observation group as compared to the control group(P < 0.01).International prostate symptom score(IPSS)and residual urine volume decreased 3 months post operation,while the maximum urine flow rate and quality of life score(QLS)increased compared with preoperative conditions(P<0.05).The satisfaction and the incidence of complications following nursing interventions were 95.74％and 12.77％for the patients in the observation group and 78.72％and 40.43％for the patients in the control group,respectively(P < 0.05).Conclusions Comfort nursing interventions can improve the psychological state of PKRP patients,enhance their short-and long-term effectsand satisfaction,and reduce the incidence of related complications.

Objective? To investigate the application of information-motivation-behavior (IMB) model in nursing care for patients with long-term indwelling bladder stoma. Methods? Totally 86 patients receiving long-term indwelling bladder stoma in the Department of Urinary Surgery, the Seventh Medical Center of Chinese PLA General Hospital from October 2015 to September 2017 were selected and divided into the control group (n=43) and the observation group (n=43) according to the random number table. Patients in the control group received conventional nursing care, while patients in the observation group received IMB-based health education on this basis. The self-care ability and quality of life of the two groups were assessed, and the incidence of complications during the follow-up was compared between the two groups after 12 months. Results? The scores of self-care ability, self-responsibility, self-conception and health knowledge as well as the total score after 12 months' nursing care were higher than those before treatment. The scores of the observation group were (43.18±4.32), (24.21±2.24), (26.04±2.63), (49.79±3.89), and (143.22±6.82), higher than those of the control group, which were (31.26±3.58), (16.74±1.55), (22.71±1.68), (38.67±1.92), and (109.38±5.04), and there were statistically differences between the two groups (P＜0.05). The total incidence rate of complications of the observation group was lower than that of the control group (6.98% vs. 37.21%,P＜0.05). Conclusions? The IMB model can enhance the self-care ability of patients with long-term indwelling bladder stoma, reduce the incidence of complications, and improve their quality of life effectively, which is worth promoting in clinical practice.