Objective:To introduce the method of laparoscopy combined with endoscopy in the treatment of gastroenterological surgery,and to evaluate the efficacy and safety of endoscopic lesion localization.Methods:A retrospective study was designed to analyze the data gathered at Qilu Hospital of Shandong University from April 2003 to June 2008,in which there were 48 operations performed by laparoscopy combined with endoscopy,including 28 gastrectomies and 20 colectomies.Results:All the 48 operations were accomplished successfully without conversion.All the lesions were located accurately with no intraoperative complications related to endoscopy.There were no postoperative complications like anastomosis leakage,incisional or intraabdominal infection.Conclusions:The combination of laparoscopy with endoscopy can raise the accuracy of lesion localization and decrease the possibility of laparotomy.