1.Autoimmune polyendocrinopathy syndrome type 2 with Guillain-Barre syndrome and scleroderma: a case report.
Jia JIA ; Jiang-yi YU ; Xin WANG ; Mei LUO
Journal of Southern Medical University 2011;31(11):1938-1940
Autoimmune polyendocrinopathy syndrome is a heterogeneous group of rare diseases characterized by autoimmune activity against more than one endocrine organ, although non-endocrine organs can be affected. We present a case of autoimmune polyendocrinopathy syndrome type 2 in a 42-year-old woman with Guillain-Barre syndrome and scleroderma. This combination of syndromes has not been reported and warrants further investigation.
Adult
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Female
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Guillain-Barre Syndrome
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complications
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diagnosis
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Humans
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Polyendocrinopathies, Autoimmune
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diagnosis
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Scleroderma, Diffuse
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complications
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diagnosis
2.A Case of Diabetic Neuropathy Combined with Guillain-Barre Syndrome.
Heung Yong JIN ; Kyung Ae LEE ; So Young KIM ; Ji Hyun PARK ; Hong Sun BAEK ; Tae Sun PARK
The Korean Journal of Internal Medicine 2010;25(2):217-220
A 59-year-old man was admitted with numbness, pain, and a tingling sensation in both lower legs. He was initially diagnosed with diabetic peripheral neuropathy based on a symptom questionnaire and a quantitative sensory test. Despite symptomatic treatment of diabetic neuropathy, he complained of worsening sensory symptoms and additional motor weakness in both lower extremities. As the motor weakness of both extremities became more aggravated over time, brain and spine imaging tests and a nerve conduction test were performed. The nerve conduction study revealed motor and sensory axonal neuropathy. In his cerebrospinal analysis, albumino-cytologic dissociation, which is compatible to the Gillian-Barre syndrome, was found. Cerebrospinal fluid analysis showed albumino-cytologic dissociation. He was treated with intravenous immunoglobulin and his neurologic deficits were gradually improved.
Diabetic Neuropathies/*complications/*diagnosis
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Electromyography
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Guillain-Barre Syndrome/*complications/*diagnosis
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Humans
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Male
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Middle Aged
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Neural Conduction
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Neurologic Examination
3.A Case of Acute Hepatitis A Complicated by Guillain-Barre Syndrome.
Yun Jeong BAE ; Kang Mo KIM ; Kwang Kuk KIM ; Jae Hyung RHO ; Hyun Ki LEE ; Yung Sang LEE ; Dong Jin SUH
The Korean Journal of Hepatology 2007;13(2):228-233
We report here a case of acute hepatitis A, which was complicated by Guillain-Barr? syndrome (GBS). A 32-year old male admitted to our hospital with the symptoms of acute hepatitis and was diagnosed to have acute hepatitis A with positive IgM anti hepatitis A virus antibody. On 9th day after the onset of jaundice, acute progressive, ascending, symmetric motor paralysis were developed and eventually respiratory failure ensued. Cerebrospinal fluid analysis showed albumino-cytologic dissociation and nerve conduction velocity test suggested a polyradiculopathy. He was diagnosed to have GBS and treated with intravenous immunoglobulin and required a ventilatory support. After 90 hospital days, he recovered in ambulatory condition with the aid of crutches. The clinical course, prognosis and the outcome of neuropathic symptoms of GBS following acute hepatitis A were relatively poor in our case.
Acute Disease
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Adult
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Guillain-Barre Syndrome/*diagnosis/etiology/therapy
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Hepatitis A/complications/*diagnosis
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Humans
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Immunoglobulins, Intravenous/therapeutic use
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Male
4.A case of overlapping Bickerstaff's brainstem encephalitis and Guillain-Barré syndrome.
De-sheng WANG ; Ying TANG ; Ye WANG
Journal of Zhejiang University. Science. B 2006;7(2):138-141
OBJECTIVEThere is no report on Bickerstaff's brainstem encephalitis (BBE) patients in China. We here report the first case of BBE in China.
METHODSClinical features, results of electromyography, electroencephalography (EEG), magnetic resonance imaging (MRI) and cerebrospinal fluid (CSF) examination were studied to clarify the characteristics of this syndrome.
RESULTSA 44-year-old man presented himself at our inpatient department with somnolence and dizziness as his initial symptoms. He developed multiple cranial nerves paralysis especially internal and external ophthalmoplegia, ataxia and tetraparesis within 1 week. His condition rapidly deteriorated, and he experienced coma. Electromyography showed indications of peripheral nerve dysfunction, electroencephalography revealed loss of basic rhythm, MRI demonstrated high-intensity abnormalities on T(2)-weighted images of medulla oblongata, and CSF albuminocytological dissociation was defined abnormally as high protein. Ten months later, he almost completely recovered.
CONCLUSIONBBE, fisher syndrome (FS) and Guillain-Barré syndrome (GBS) are similar clinically; BBE and FS were proposed to be the variant of GBS.
Adult ; Brain ; pathology ; Coma ; Diagnosis, Differential ; Electroencephalography ; Electromyography ; Encephalitis ; complications ; Guillain-Barre Syndrome ; complications ; Humans ; Magnetic Resonance Imaging ; Male ; Medulla Oblongata ; pathology ; Time Factors
5.A Case of Acute Motor and Sensory Axonal Neuropathy Following Hepatitis A Infection.
Yoon Sik JO ; Sang Don HAN ; Jin Yong CHOI ; Ick Hee KIM ; Yong Duk KIM ; Sang Jun NA
Journal of Korean Medical Science 2013;28(12):1839-1841
Acute motor and sensory axonal neuropathy (AMSAN) are recently described subtypes of Guillain-Barre syndrome characterized by acute onset of distal weakness, loss of deep tendon reflexes, and sensory symptoms. A 21-yr-old male was transferred to our hospital due to respiration difficulties and progressive weakness. In laboratory findings, immunoglobulin M antibodies against hepatitis A were detected in blood and cerebrospinal fluid. The findings of motor nerve conduction studies showed markedly reduced amplitudes of compound muscle action potentials in bilateral peroneal, and posterior tibial nerves, without evidence of demyelination. Based on clinical features, laboratory findings, and electrophysiologic investigation, the patient was diagnosed the AMSAN following acute hepatitis A viral infection. The patient was treated with intravenous immunoglobulin and recovered slowly. Clinicians should consider this rare but a serious case of AMSAN following acute hepatitis A infection.
Acute Disease
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Electromyography
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Guillain-Barre Syndrome/*diagnosis/drug therapy/etiology
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Hepatitis A/complications/*diagnosis
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Humans
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Immunoglobulins, Intravenous/therapeutic use
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Male
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Young Adult
6.A case of Guillain-Barre syndrome complicated with posterior reversible encephalopathy syndrome.
Ying YANG ; Jian-hua FENG ; Yu-wen DAI
Chinese Journal of Pediatrics 2013;51(6):477-478
Biomarkers
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blood
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Brain
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diagnostic imaging
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pathology
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Brain Edema
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etiology
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pathology
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Child
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Diagnosis, Differential
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Electroencephalography
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Guillain-Barre Syndrome
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complications
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diagnosis
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therapy
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Humans
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Magnetic Resonance Imaging
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Male
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Posterior Leukoencephalopathy Syndrome
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complications
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diagnosis
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therapy
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Radiography
7.Clinical presentations as predictors of prolonged mechanical ventilation in Guillain-Barré syndrome in an institution with limited medical resources.
Umarudee TOAMAD ; Chanon KONGKAMOL ; Suwanna SETTHAWATCHARAWANICH ; Kitti LIMAPICHAT ; Kanitpong PHABPHAL ; Pornchai SATHIRAPANYA
Singapore medical journal 2015;56(10):558-561
INTRODUCTIONSevere Guillain-Barré syndrome (GBS) causes ventilatory insufficiency and the need for prolonged artificial ventilation. Under circumstances where medical care for patients with severe GBS is required in a resource-limited institution, identifying initial clinical presentations in GBS patients that can predict respiratory insufficiency and the need for prolonged mechanical ventilation (> 15 days) may be helpful for advanced care planning.
METHODSThe medical records of patients diagnosed with GBS in a tertiary care and medical teaching hospital from January 2001 to December 2010 were retrospectively reviewed. The demographic data and clinical presentations of the patients were summarised using descriptive statistics. Clinical predictors of respiratory insufficiency and the need for prolonged mechanical ventilation (> 15 days) were identified using univariate logistic regression analysis.
RESULTSA total of 55 patients with GBS were included in this study. Mechanical ventilation was needed in 28 (50.9%) patients. Significant clinical predictors for respiratory insufficiency were bulbar muscle weakness (odds ratio [OR] 5.08, 95% confidence interval [CI] 1.31-21.60, p = 0.007) and time to peak limb weakness ≤ 5 days (OR 0.75, 95% CI 0.62-0.91, p < 0.001). Bulbar muscle weakness (p = 0.006) and time to peak limb weakness ≤ 5 days (p < 0.001) were also found to be significantly associated with the need for prolonged mechanical ventilation (> 15 days).
CONCLUSIONBulbar weakness and time to peak limb weakness ≤ 5 days were able to predict respiratory insufficiency and the need for prolonged mechanical ventilation in patients with GBS.
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Female ; Guillain-Barre Syndrome ; diagnosis ; therapy ; Humans ; Male ; Middle Aged ; Muscle Weakness ; complications ; Odds Ratio ; Regression Analysis ; Respiration, Artificial ; Respiratory Insufficiency ; therapy ; Retrospective Studies ; Tertiary Care Centers ; Young Adult
8.A Korean patient with Guillain-Barré syndrome following acute hepatitis E whose cholestasis resolved with steroid therapy.
Sung Bok JI ; Sang Soo LEE ; Hee Cheul JUNG ; Hong Jun KIM ; Hyun Jin KIM ; Tae Hyo KIM ; Woon Tae JUNG ; Ok Jae LEE ; Dae Hyun SONG
Clinical and Molecular Hepatology 2016;22(3):396-399
Autochthonous hepatitis E virus (HEV) is an emerging pathogen in developed countries, and several cases of acute HEV infection have been reported in South Korea. However, there have been no reports on HEV-associated Guillain-Barré syndrome (GBS) in Korea. We recently experienced the case of a 58-year-old Korean male with acute HEV infection after ingesting raw deer meat. Persistent cholestasis was resolved by the administration of prednisolone. At 2.5 months after the clinical presentation of HEV infection, the patient developed weakness of the lower limbs, and was diagnosed with GBS associated with acute hepatitis E. To our knowledge, this is the second report on supportive steroid therapy for persistent cholestasis due to hepatitis E, and the first report of GBS in a Korean patient with acute HEV infection.
Acute Disease
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Alanine Transaminase/blood
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Antibodies, Viral/blood
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Aspartate Aminotransferases/blood
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Bilirubin/analysis
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Cholestasis/*drug therapy
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Guillain-Barre Syndrome/complications/*diagnosis
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Hepatitis E/*diagnosis/etiology
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Hepatitis E virus/immunology
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Humans
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Immunoglobulin M/blood
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Liver/pathology
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Male
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Middle Aged
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Prednisolone/therapeutic use
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Republic of Korea
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Steroids/*therapeutic use