Objective:To observe the change and clinical significance of glucocorticoid receptor on peripher alleukocytes frompatients with Graves disease.Methods:By radioligand binding assay,GR contents of peripher alleukocytes were determinated in 61 patients with Graves disease,20 healthy volunteers as controls.Results:The GR contents in Graves disease group were significantly lower than that of the normal control group(t = 7.389,P = 0.000 1).In 61 patients with graves disease,GR contents gradually decreased(F = 7.389,P = 0.000 1)with increased Graves disease severity.GR contents were negatively correlated with FT3,FT4 and TSH,correlation coefficients were 0.741(t = 5.643,P = 0.013),0.689(t = 5.119,P=0.025)and 0.755(t =6.391,P=0.009),respectively.GR contents were decreased(t = 4.274,P= 0.000)while patients complicated bythyrotoxic exophthalmos,but GR contents were not statisticallysignificantlydeclined while patients complicated by hyperthyroid heart disease(t = 0.273,P = 0.786) or thyrotoxic periodic paralysis were(t =0.961,P = 0.336).Conclusion:The binding capacity of GR on peripheral leukocytes in the Graves disease patients is lower than normal.This change may play roles in the pathogenic process of Graves disease and probably relate to the disease severity,thyrotoxic exophthalmos complicated.

Objective To study the correlation of nurse -perceived organizational atmosphere climate and their job involvement. Method About 465 clinical nurses were involved in the investigation by nursing organizational climate scale and work engagement scale. Results The total score on the organizational climate and job involvement were (149.24 ± 21.36) and (52.80 ± 6.31), respectively. The nurse -perceived organizational climate was positively correlated with job involvement ( P <0.01). Conclusions The nurse-perceived organizational climate and job involvement are at a medium level. Nursing managers should create a good organizational climate and promote their positive status into nursing, thereby improving the quality of care.

Objective:To investigate the status and influencing factors of quality of life among disabled elderly whose home care services were paid by the long-term care insurance in Guangzhou, in order to provide a scientific evidence for improving their quality of life and improving the long term care insurance system.Methods:A convenience sample of 161 disabled elderly whose home care services were paid by the long-term care insurance were recruited and investigated. A cross-sectional survey was conducted by general information questionnaire, World Health Organization Quality of Life Brief Scale, Barthel Index, Self-rating Depression Scale, Self-rating Anxiety Scale and World Health Organization Happiness Index Scale.Results:The score of the quality of life among disabled elderly was 41.17±7.79. And the score of its four dimensions in descending order: environment, social relationships, psychological and physical with (11.38 ± 2.71), (10.36 ± 3.16), (9.86 ± 2.08), (9.56 ± 1.89) points. The multiple linear regression analysis found that frequencies of outdoor activities per week, frequencies of hospitalization in the past year, subjective well-being, depression and anxiety influenced the quality of life of the disabled elderly( P<0.05). Conclusions:The quality of life of disabled elderly is not optimistic. Nurses in home care institutions should formulate personalized nursing intervention based on influencing factors to improve the quality of life of disabled elderly, while providing a basis for optimizing long-term care insurance policies.