Objective The present study was aimed to promote the informatization process of scientific research contract and enhance the management level and quality of hospital contract.Methods Legal risks existing in traditional contract management mode in a 3A grade hospital in Shanghai,were taken as an example for exploration on how to reduce and avoid the legal risks by using modern information technology.Results There were many problems in the traditional contract management mode,its main representations were:low efficiency,difficult to supervise,hard to be shared,and the risk of not-fixed content.On the contrary,modern information technology has the following merits,such as:reducing the legal risk caused by human factors,the full control of the contract,shared information,decreased risk,consistent data,and fair approval.Conclusions Modern information technology will be helpful to control risks in the whole process of scientific research contract,and refine the management of scientific research contract.