The ischemic heart disease has been endangering human health seriously. Although there are many kinds of anti-ischemic drugs, most of them are lacking in tissue specificity, which together with a remarkably reduced blood circulation in the ischemic zone often lead to a quite low drug distribution in the targets. Myocardial ischemia can cause a lot of pathophysiological changes, such as the enhanced permeability of the endothelial cell membrane, the up-regulated expression of various cell adhesion molecules on endothelium, the exposure of intracellular antigenic components, the decrease of pH within the ischemic zone, and so on. To date, some of these changes have been exploited with limited success to gain the passive, active and physicochemical targeting of diagnostic or therapeutic drugs to myocardial ischemic regions. However, more effective delivery strategies are still eagerly needed. Here, we reviewed and discussed the potential targeting-delivery mechanisms and strategies, used or may be used in the future, for myocardial ischemic regions.

BACKGROUND: Poly methyl methyacrylate (PMMA) has been widely used as a denture base material in dental field for a long time. However, the fracture of acrylic resin dentures is an unresolved problem in prosthodontics. Therefore, how to improve the flexural strength of repaired denture seems to be extremely important. OBJECTIVE: To study the effect of embedding different amounts of metal wires on the flexural strength of repaired denture bases. METHODS: Twenty-five rectangular specimens (50 mm× 30 mm × 2.5 mm) were fabricated using heat-cured acrylic resins and randomly and evenly divided into five groups: A, B, C, D, and E. All specimens were fractured through the use of universal testing machine, and the flexural strengths were tested. Following preparation of fracture surfaces, one to four metal wires were separately embedded in the groups B, C, D, and E. No metal wires were embedded in the group A. All fractured specimens were repaired using self-curing resins. The flexural strengths were measured again using the same testing machine, and the percentages of strength recovery were calculated. RESULTS AND CONCLUSION: After repair, the flexural strengths were obviously reduced (P < 0.01). Compared to group A, the percentages of strength recovery were significantly increased in groups C, D, and E (P < 0.05). There was no significant difference in the percentage of strength recovery among groups C, D, and E (P > 0.05). These results indicate that embedding two to four metal wires can improve the flexural strength of denture bases.

Objective: To study the effect of treatment of articulation disorder in patients with velopharygeal incompetence(VPI) after operation for cleft palate. Methods: Articulation disorder was treated by velophary-geal obturator in 135 patients with VPI, the rate of VPI(RVPI),improving rate of VPI(IRVPI),the value of third formant frequency(F3)of Chinese vowels and pronunciation were observed before and 180 days,1 and 2 years after treatment. Results: After treatment RVPI was decreased (P

Objective:To analyzise the upper removable partial denture for Kennedy Ⅰdentition defect how to affects the consonants acoustic characteristics. Methods: Before and after restoration use the computer speech lab(CSL) to analyze 12 patients' acoustic characteristics. Then at 1, 2, 4 and 8 weeks, to compare each patient different time's area of energy concentration, the first area of energy concentration band width of consonants /s/,/sh/,/j/; the locus of /t/. Results:There was significant difference between the area of energy concentration and the first area of energy concentration band width in /s/ of the groups before restoration and at the beginning and after one week(P0.05) in other consonants groups.Conclusion: The main area which affects the acoustic characteristics is the anterior part of the anterior palate plate of the removable partial denture. From the acoustics point of view, to lay the major connector on the upper gingival, the median line area are not suitable, while the posterior part of the hard palate fitting to lay it.

Objective To establish 3D data-base on artificial resin teeth with 3D layer scanning digitizer. Methods Artificial resin teeth were measured with a CMS-400 3D digitizer by cutting and scanning layer-by-layer, 3D data points of each tooth acquired and the 3D models of these teeth reconstructed with a computer. Results 3D models of 3D data-base on artificial resin teeth were obtained. The characteristics of these 3D images were clear and accurate. Conclusion The complicated teeth moulds can be measured accurately with the 3D digitizer since there are no measuring blind spots.

Objective To discuss the foreground of application of reverse engineering reconstruction of dental models and to establish the foundation of developing a system for complete denture CAD/CAM. Methods The models of an edentulous jaw were measured with reverse engineering, and the 3D models were reconstructed with a computer. Results 3D models of the edentulous jaw were achieved. The characteristics of these 3D images were clear and accurate. Conclusion CAD models are reconstructed with reverse engineering accurately and technical problems in 3D model of complete denture CAD/CAM are resolved.

Objective To analyze the clinicopathologic features,prognosis and influencing factors of invasive cervical adenocarcinoma.Methods Clinical and pathologic data of 96 cases of invasive cervical adenocarcinoma and 100 cases of squamous carcinoma of the cervix treated in Shanxi Cancer Hospital from years of 1998 to 2007 were retrospectively analyzed.Results The morbidity of cervical adenocarcinoma was showing the arise and low-age trend.The overall 5-year survival rate was 60.4 ％,The overall survival rates of patients with stage Ⅰ,Ⅱ,Ⅲ,and Ⅳ were 82.9 ％,51.5 ％,13.3 ％ and 0,respectively.Ocervical adenocarcinoma had many prognosis-related factors:clinical stage,lymmphatic spread,vascular invasion,volume of tumor,histologic grade.Multivariate analysis showed that clinical stage,lymph nodal metastasis and vascular invasion were independent prognosis-related factors.However,whether ovary was reserved,it was irrelative to prognosis.Conclusion The morbidity of cervical adenocarcinoma is showing the arise and low-age trend.Earlier diagnosis is extremely important for improving the survival rate of cervical adenocarcinoma,the reserved ovary doesn't influence the overall 5-year survival rate for young women with early cervical adenocarcinoma.

Objective To study the practical value of 3 dimensional computed tomography on diagnosis of bladder tumor. Methods Fifteen patients with bladder masses were examined by thin layer computed tomography.The results of 3 dimensional reconstructed images were compared with the final diagnosis and the pathological stages. Results According to 3 dimensional reconstructed images,among the 15 cases,12 cases of bladder cancer were diagnosed,and the pathological types were transitional carcinoma.Two cases were diagnosed as benign tumor (leiomyoma),and the other one was colon cancer,which invaded bladder.The accuracy was 100%.The clinical stages were determined.Of the 12 bladder carcinomas,5 was in stage T 1,3 in T 2,3 in T 3 and 1 in T 4.The accuracy of staging was up to 83%(10/12) compared with pathological stages. Conclusions The 3 dimensional reconstructed technology may improve the accuracy of staging of bladder carcinoma,and to provide important evidence for surgery options.

Acute hepatic failure was induced in rats with intraperitoneal administration of D-galactosamine.Serum and tissue amino acid profiles of the animals were studied. Except for arginine, serum levels of all amino acids were elevated. This is in variance with the findings of Fischer and other investigators. In their studies, the decreased levels of BCAA could be related to the administration of dextrose. In our study, the serum BCAA/AAA ratio was decreased and it was correlated negatively with the dosage of D-galactosamine (r =-0.789). Amino acid profiles in the liver,kidney and muscles were significantly altered. The chracteristics of the changes indicated that enhanced proteolysis of tissue proteins was the major factor accounting for the elevation of serum amino acid levels. Hepatic coma might be related to the increase of aromatic amino acids in the brain. It is usually difficult for glycine, cystine, asparagine and threonine to penetrate the blood-brain-barrier. Elevation of their levels in the brain might be a consequence of increased permeability of the blood-brain-barrier. Further studies are needed to clarify the role of GABA in hepatic coma.

In this study, 38 experimental subjects of diabetes mellitus were given pectin 25g extra per day orally under carefully controlled dietary plan for six weeks. Another 38 cases were selected at random as control group.Pre- and posttreatrnent, blood and urine sugar and serum insulin of each subject were measured and compared. The results were: 1) the blood sugar dropped markedly as compared with that of pretreatment (p05). 2) sugar in urine decreased evidently in contrast with control group, but no difference was seen in the volume of urine between the two groups. 3) serum insulin levels dropped significantly when compared with control group (p