To the situation that the students of TCM is not good at clinical skill,this article analyzed the reasons of this situation and put forward several suggestions including building the clinical experience subject system,experimental resources,teaching monitoring system and the experimental base.

OBJECTIVE:A RP-HPLC method to determine the contents of furacilin and ephedrine hydrochloride in compound furacilin nasal drops was established METHODS:Chromatographic detection was performed with a mixture of methanol-water-triethylamine-acetic acid(12∶88∶0 2∶1) as mobile phase and Kromasil C18(4 6mm?250mm,5?m) as separate column Chloramphenicol was selected as internal standard and the detection wavelength was 254nm RESULTS:The ingredients of compound furacilin nasal drops and internal standard were well separated within 18min Good linearities and recoveries for furacilin and ephedrine hydrochloride were obtained in their assay ranges CONCLUSION:The RP-HPLC method was found to be simple,accurate and suitable for the quality control of compound furacilin nasal drops

OBJECTIVE:To prepare ganciclovir hydrochloride chitosan eye drops and establish its quality control method.METHODS:The eye drops was prepared using chitosan as thickening agent and synergist with ganciclovir as principal agent.The content of ganciiclovir was determined by HPLC.The stability of the preparation was investigated as well.RESULTS:The prepared eye drops was colorless transparent glutinous limpid liquid with its identification items all up to the related standards stipulated in Chinese Pharmacopoeia(2005 edition).The linear range of ganciclovir was 5～80 mg?L-1(r=0.999 9) with average recovery of 99.02%(RSD=0.71%).The preparation was stable under light with all its indexes showed no obvious change in the accelerated test at 6 month.CONCLUSION:The preparation technology is simple and feasible and the quality of preparation is stable and controllable with a validity duration tentatively set at 2 years.

OBJECTIVE: To compare the pharmacokinetics and relative bioavailability between ganciclovir-chitosan eye drops and ganciclovir eye drops in rabbit eyes. METHODS: Japan big-eared rabbits were randomly assigned to the receive 50 ?L ganciclovir-chitosan eye drops (experiment group) or ganciclovir eye drops (control group) in both eyes. The rabbit tears,corneas and aqueous humor were collected at different time for the determination of drug concentration by RP-HPLC. The pharmacokinetics parameters were calculated as well. RESULTS: In the experimenal group,the half-life(t1/2) in tears,corneas and aqueous humor were 15.41,45.21,59.43 minutes,respectively versus 16.22,32.55,and 48.53 minutes in the control group. The Cmax were 2.03 ?g?mL-1 and 1.22 ?g?mL-1,respectively. In the experimental group,the AUC0→240 in tears,corneas and aqueous humor were 1.66,1.89,and 2.77 times those in control group. CONCLUSION: The bioavailability of ganciclovir-chitosan eye drops was significantly higher than that of ganciclovir eye drops.

Objective:To discuss the choice of anti-infective drugs and the significance of pharmaceutical care for COPD patients with pulmonary infection. Methods:Clinical pharmacists performed pharmaceutical care for a COPD patient with pulmonary infection including such aspects as drug selection, treatment course, drug interaction, adverse reactions and so on. Results:By providing phar-maceutical care for the patient, the problems in the treatment were identified and solved in time, and the rationality of drug treatment was improved. Conclusion:By participating in clinical practice, clinical pharmacists can assist physicians in improving the safety and efficacy of drug treatment and providing pharmaceutical care for patients.

0.05)and the main pharmacokinetic parameters were close to each other.CONCLUSION:No stereoselective differences lies in the pharmacokinetics processe of amlodipine enatiomers in the body of rabbits.

OBJECTIVE:To construct the database of“The Time and Age Limit in the Use of Common Orally Adminis-tered Drugs”in order to guide the rational drug use in patients.METHODS:The frequently used instructions of common orally administered drugs in the hospital where the authors worked were collected,and then were classified and listed according to the elements in“The Time and Age Limit in the Use of Common Orally Administered Drugs”,and further summarized according to the basic knowledge in drug administration.RESULTS:Ante cibum drugs accounted for22.2%,post cibum drugs11.7%,either ante cibum or post cibumor or unmarked drugs59.4%,bedtime drugs6.7%,wholly swallowed drugs12.2%,chewed drugs1.7%,children restricted drugs32.2%,and the drugs taken once daily with the set time accounted for13.9%.CONCL_ USION:The construction of“The Time and Age Limit in the Use of Common Orally Administered Drugs”database can guide patients to use medicine rationally.

Objective To explore the relationship between homocysteine(HCY),glycosylated hemoglobin(HbA1c),lipids and posterior circulation ischemia and the clinical significance of their levels in the posterior circulation ischemic (PCI)diseases. Methods Difference between PCI were diagnosed in 140 examinees and a healthy control group,with fasting serum,HCY, HbA1c,total cholesterol (TC),triglyceride (TG),high density lipoprotein cholesterol (HDL-C)and low-density lipoprotein cholesterol (LDL-C)were detected.Results HCY and HbA1c were significantly higher,HDL-C was significantly lower in the patients with PCI,two independent sample t-test showed a significant difference between the test group and control group (P <0.001 and P =0.001),the remaining lipid indicators was not statistically significant.Spearman rank correlation analysis showed that HCY levels had significant positive correlation (P <0.001)and TG levels had significant negative cor-relation (P =0.013)with the subjects age,HCY levels had significant negative correlation with TG levels(P = 0.028), HbA1c levels had significant positive correlation with TG levels and LDL-C levels(P =0.001 and P =0.027).Conclusion High levels of HCY and HbA1c were closely associated with PCI,which HCY and HbA1c should be attached great impor-tance to the effective prevention and treatment and improve of PCI.

OBJECTIVE:To get to know medical staff's recognition of ADR monitoring in our city.METHODS:The concept,reporting consciousness,range and reasons for ADR reporting,reporting processes,professional organization of ADR and law consciousness of ADR etc.were investigated in400medical staff members through questionnaires on“Medical Staff's Recognition Degree to the Monitoring of ADR”.RESULTS:The medical staff in our city were basically clear about the range and the reasons for ADR reporting,but they lacked adequate recognition to the concept and the consciousness of ADR report?ing,they were not clear about the reporting processes and the organization of ADR and they lack the law consciousness of ADR reporting.CONCLUSION:It is necessary to carry out training on professional knowledge,laws and regulations of ADR among the medical staff so as to enhance their recognition to ADR monitoring and to make ADR monitoring as a self-conscious behavior.

OBJECTIVE:To systematically review the efficacy of Qijiao shengbai capsule in the adjuvant treatment of leukope-nia,and provide evidence-based reference for the clinical treatment. METHODS:Retrieved from CJFD,VIP,Wanfang Database and Medline and EMBase,randomized controlled trials(RCT) about the efficacy of Qijiao shengbai capsule (test group) versus blank control(control group) in the adjuvant treatment of leucopenia were collected. Meta-analysis was performed by using Rev Man 5.2 software after the quality assessment and data extraction. RESULTS:A total of 15 RCTs were included,involving 1 383 patients. Results of Meta-analysis showed the total effective rate [OR=0.31,95%CI(0.23,0.43),P<0.001],obvious effective rate [OR=0.31,95%CI(0.24,0.41),P<0.001],leukocyte count [MD=-1.04,95%CI(-1.10,-0.98),P<0.001] and myelosuppres-sion reduction [OR=0.27,95%CI(0.14,0.52),P<0.001] in test group were significantly higher than control group,there were sig-nificant differences. Only 9 patients had adverse reactions of mild diarrhea,nausea and other symptoms,and it relieved after symp-tomatic treatment. CONCLUSIONS:Qijiao shengbai capsule has achieve good efficacy in the adjuvant treatment of leukopenia. Due to the limits of quality and sample size,more strict designed,long-term follow-up of large scale RCTs are needed for the fur-ther verification of the conclusion.