1. Absorption and excretion of CT-707 in healthy male subjects studied by radioisotope tracer method
Guijuan HAN ; Ji JIANG ; Weiwei OUYANG ; Hong LUO ; Xiaojun ZHANG ; Minghua WANG
Chinese Journal of Clinical Pharmacology and Therapeutics 2021;26(12):1407-1412
AIM: To study the absorption and excretion of CT-707 in healthy male subjects. METHODS: Six healthy male subjects received a single 300 mg (120 μCi) oral dose of radio-labeled CT-707 as a suspension in a fasted state. Blood, urine and feces were collected. Radioactivity concentrations were measured by liquid scintillation counting (LSC). The pharmacokinetic parameters of total radioactivity in plasma were calculated by WinNonlin (Pharsight version 8.1) software according to the non-compartment model. The recovery rate of total radioactivity in urine and feces was calculated according to the weight and radioactivity concentration of urine and feces collected at each time interval. RESULTS: After a single 300 mg oral of radio-labeled CT-707 552 h (23 d) as a suspension in a fasted state, the mean AUC
2.A retrospective study on 464 bullous pemphigoid patients in Northeast China.
Qiang WANG ; Ruiqun QI ; Jianping LI ; Fengqiu LIN ; Xianwei HAN ; Xiuyu LIANG ; Xiaodong SUN ; Yue FENG ; Kaibo WANG ; Chunlin JIN ; Guijuan XU ; Tienan LI ; Changhong CHU
Chinese Medical Journal 2022;135(7):875-877
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