According to his own study and personal clinical experience, the author discussed the role of point injecting in the treatment of rheumatoid arthritis (RA). from three aspects of circulatory system, nervous system and its physical stimulation

s Objective: To identify neural correlates for the recognition of familiar verbal voices by measuring regional blood oxygen level-dependent (BOLD) signal by functional magnetic resonance imaging (fMRI). Methods:Thirteen Chinese health male subjects (mean age 26.1 years, SD= 2.9years) participated in the study. All subjects were right-handed and Han nationality. The subjects listened to familiar (subjects' friends) and unfamiliar voices when functional scanning. Functional data were acquired using a 1.5T MRI (GE Systems, USA), and were analyzed using statistical parametric mapping 99 (SPM99). A fixed-effects model was employed to assess the difference in BOLD response between 'familiarity' and 'unfamiliarity' conditions (P

Objective To explore the significance of language proficiency in bilingual perception in Chinese-English late bilingual subjects with block-design functional magnetic resonance imaging (bfMRI).Methods Thirteen right-handed Chinese Han healthy male late bilinguists who had limited English proficiency were scanned while listening to short sentences in Chinese and English.Based on blood oxygenation level-dependent (BOLD) signal efficacy,functional images were collected using a 1.5-T MRI.Statistical parametric mapping 2 (SPM2) was used to analyze the data of functional images (P＜0.001,KE＞ 100).Results For Chinese familiar voices,more significant activation was observed in the right superior temporal gyrus than that for English familiar voices.On the contrary,more significant activations for English familiar voices were observed in the left precuneus,middle frontal gyrus and left posterior cingulate cortex compared with that for Chinese familiar voices.For Chinese unfamiliar voices,more significant activations were observed in the right middle temporal gyrus and right medial frontal gyrus than that for English unfamiliar voices.In contrast,more significant activations by English unfamiliar voices were observed in the right inferior frontal gyrus,middle frontal gyrus and left middle temporal gyrus compared with that for Chinese unfamiliar voices.Conclusion Language proficiency may play an important role in different language perception from auditory level.

Animals ; Caenorhabditis elegans ; metabolism ; radiation effects ; Caenorhabditis elegans Proteins ; genetics ; metabolism ; Light ; Lysine ; analogs & derivatives ; genetics ; metabolism ; Promoter Regions, Genetic ; Protein Transport ; RNA, Transfer ; genetics ; metabolism ; Tumor Necrosis Factor Ligand Superfamily Member 14 ; metabolism

Objective To investigate the changes of the levels of sonic hedgehog (SHH) and vascular endothelial growth factor (VEGF) in serum and its relationship with collateral circulation in patients with symptomatic middle cerebral artery stenosis. Methods From January 2015 to January 2018, a total of 268 patients with acute ischemic stroke confirmed as unilateral middle cerebral artery M1 segment (MCA-M1) severe stenosis or occlusion by digital subtract angiography (DSA) were enrolled. The baseline clinical data were collected. According to the establishment of collateral circulation shown by DSA, they were divided into good collateral circulation group (152 patients) and poor collateral circulation group (116 patients). The levels of SHH and VEGF in serum were detected by enzyme linked immunosorbent assay (ELISA), the expression characteristics of SHH and VEGF in serum and the relative factors influencing the establishment of collateral circulation were analyzed. Results The levels of serum SHH and VEGF in good collateral circulation group were significantly higher than those in poor collateral circulation group (P < 0.01). Pearson correlation analysis showed that there was a positive correlation between SHH and VEGF (r=0.758, P < 0.01). Multivariate Logistic regression analysis showed that the levels of serum SHH ( OR=0.310, 95% CI 0.117-0.819, P=0.018) and VEGF ( OR=0.361, 95% CI 0.147-0.887, P=0.026) were independent protective factors for the establishment of collateral circulation. Diabetes ( OR=3.094, 95% CI 1.321-7.245, P=0.009) was independent risk factor for the establishment of collateral circulation. Conclusions The levels of serum SHH and VEGF are closely related to the formation of collateral circulation and they are independent protective factors. SHH may be involved in the establishment of cerebral collateral circulation by regulating the expression of VEGF and diabetes is not conducive to the formation of collateral circulation.