Adult ; Child ; Humans ; Metabolic Syndrome ; diagnosis ; etiology ; physiopathology ; Pediatrics ; trends ; Research ; trends

Adolescent ; Child ; Diabetes Mellitus, Type 2 ; diagnosis ; etiology ; therapy ; Diet ; Exercise ; Humans ; Self Care

Objective To observe the clinical efficacy of terbinafine in the treatment of complicated vulvovaginal candidiasis.MethodsA case of 100 patients with complicated vulvovaginal candidiasis treated in our hospital from January 2015 to December 2016, were randomly divided into treatment group (terbinafine) and the control group (fluconazole),each 50 cases,the treatment cycle is four weeks, the therapeutic effect of two groups was observed.ResultsIn the treatment group 45 cases cured, three cases were markedly effective, two cases effective, the total effective rate was 96%;In the control group 41 cases cured, three cases were markedly effective, six cases effective, the total effective rate was 88%.The difference between the two groups was statistically significant.(P<0.01).ConclusionTerbinafine treatment of complicated vulvovaginal candidiasis was significant.

Objective To compare the costs and effectiveness between the laparoscopic cholecystectomy (LC) and the open cholecystectomy (OC). Methods Clinical data of 97 patients treated either by LC (n=41) or OC (n=56) were retrospectively reviewed. Results The hospital stay, postoperative hospital stay, hospitalization expenditure and medical incomes in Group LC and Group OC were (11.4?3.0) days and (15.1?4.2) days (t=-4.811,P=0.000), (6.1?0.9) days and (10.7?2.4) days (t=-11.673,P=0.000), (8 723.8?1 077.2) yuan and (6 423.4?1 398.4) yuan (t=8.791, P=0.000), (6 236.4?591.0) yuan and (3 426.6?683.2) yuan (t=21.162,P=0.000), respectively. There were no statistical significances between the two groups in preoperative hospital stays and occurrences of complications (t=1.684, P=0.095;?2=0.434,P=0.510). Conclusions Compared with the OC, health resources were more properly utilized but costs were higher in the LC.

Objective To analyse the pathogenesis,diagnosis and treatment of tethered cord syndrome(TCS) and to improve the knowledge of the disease.Method The clinical data of 16 cases with TCS who underwent surgical lysis were analyzed,retrospectively.Results Thirteen cases were followed-up for 6 months to 1 year.Three cases with handicap of lower limb function and aesthesia and rectum and bladder sphincter dysfunction got good outcome,and 2 cases showed no improvement,while 10 cases with no symptoms(didn′t) appear TCS.Conclusions It is necessary to diagnose and manage as early as possible.The tethered cord lysis can relieve the symptoms of some cases and control development of TCS.

What is education is a masterpiece on education of karl Jaspers,which gives a profound impact on Germany and the world's education.This paper makes an analysis about it on the basis of the essence of education,philosophical base,teacher- student relationship,university idea and so on,and makes a further efforts to point out that this viewpoint will have deep inspira- tion to the teaching method reform we are now promoting.

OBJECTIVE: To study the effects of different triptolide formulations given by micro electro mechanical systems (MEMS) micro-needles on skin injury of rheumatoid arthritis rats . METHODS: Three formulations of triptolide were prepared including the aqueous solution of 20% propylene glycol, liposomes, and liposomes hydrogel patch. Rats with rheumatoid arthritis induced by collagen II were used, and 100 and 200 μm MEMS micro-needles treatment was performed on left and right sides of rat skin. The lactate dehydrogenase (LDH) activities were measured by ultraviolet spectro-photometric method. RESULTS: After processed by MEMS micro-needle, the LDH activities of RA rat skin did not change obviously (P > 0.05). All triptolide formulations increased LDH activities (P < 0.05), and the increasement of solution group was largest (P < 0.001), followed by lipsomes group (P < 0.01) and liposomes hydrogel patch (P < 0.05). Nevertheless, there was no significant difference between left and right sides of rat skin (P > 0.05). CONCLUSION: Both 100 and 200 μm MEMS micro-needles were safe for enhancement of transdermal delivery in rheumatoid arthritis rats. The skin injury was observably relieved when triptolide was prepared as liposomes hydrogel patch which is a perfect formulation for transdermal delivery of triptolide. Copyright 2012 by the Chinese Pharmaceutical Association.

Objective To Investigate the preparation method, the release profile and structure of the polyelectrolyte layer- by-layer coated chitosan-alginate microgels. Methods The cores of the microgels were prepared by a high voltage electrostatic system, and the semipermeable membrane outside the microgel was polyelectrolyte deposits on the core surface through electrostatic attraction. The influences of different ratios of materials on the expansion property and the in vitro cumulative release of the coated microgels were evaluated by a single factor experiment. Results The prepared polyelectrolyte-coated microgels were well-shaped, with a narrow range of diameter distribution. The lag time of in vitro release was 2. 67 h; the release was rapid after lagging, with the cumulative in vitro release being 72% within 3 h. Conclusion Polyelectrolyte layer-by- layer coated chitosan-alginate microgels can release payload in a pulsed fashion in vitro.

Objective To Investigate the in vitro and in vivo release of chitosan-alginate microgels coated layer-by-layer by polyelectrolyte self-assembly. Methods The cores of the microgels were made by gelatinization using electrostatic microencapsulated and coated by polyelectrolytes using electrostatic attraction. The effects of different layers and ratios of polymer on the in vitro lease of FITC-dextran were evaluated. Histrological examination was carried out to observe the in vivo release process by injecting the coated microgels into mice. Results The results showed that alginate and calcium chloride concentrations and polyelectrolyte layers markedly affected the lag time of pulsed release and the relasing speed after lagging. Conclusion The release of microgels coated layer-by-layer by polyllectrolyte can be controlled in vitro and can be observed in vivo; meanwhile, the microgels are safe and have good biocompatibility.

Pulsed drug delivery (PDD), which can be released at well-defined time points as the therapy needs, can decrease the frequency and avoid taking drug at night, thus improving patient compliance. Here we introduce three kinds of programmed PDD systems independent of external chemical triggering; they are divided according to the triggering mechanisms, degradation-triggered PDD, osmotic pressure-triggered PDD, and both degradationi and osmotic pressure-triggered PDD. This paper reviews preparing technique, release mechanisms and influencing factors of the three PDD systems. The release profiles of pulsatile PDD can be regulated for different therapeutic needs, requiring no external triggers; especially that the PDD system triggered by both degradation and osmotic pressure has a bright future.