OBJECTIVETo explore the pattern of road traffic injuries (RTI) in China and to furnish evidence to formulate strategy and measures to improve RTI.

METHODSUsing the data from the National Statistical Office, Ministry of Communications and the Traffic Administration bureau, factors as the time trends, features and risk factors of RTI were analysed for all provinces in China.

RESULTSOver the past 51 years, RTI have increased more than 100-fold. The fatality rate of RTI was up to 8.51 per 100 000 population in 2001, almost doubled for the past ten years. In the past decade, the deaths of RTI always held in the front fifth rank in Guangdong, Shandong and Zhejiang. Calculating mortal coefficient (MC) to evaluate the severity of RTI, Tibet, Xinjiang, Qinghai, Ningxia and Gansu stood the worst. The 26 - 45 years age-group represented the majority of all fatalities and overall casualties, and the age-group over 65-year olds having an increased trend in China. The main risk factors of RTI were road quality, motorization, volume of traffic transportation, maldriving and the behaviors of pedestrians.

CONCLUSIONSThe main means to reduce RTI would include: improving road traffic environment, setting road safety rules and securing compliance, changing perception, understanding and practice traffic safety.

Accidents, Traffic ; mortality ; statistics & numerical data ; trends ; Adult ; Automobile Driving ; China ; epidemiology ; Female ; Humans ; Male ; Middle Aged ; Motor Vehicles ; Motorcycles ; Risk Factors ; Sex Factors ; Wounds and Injuries ; epidemiology ; etiology ; mortality

OBJECTIVETo analyze and summarize the secular trend and influencing factors of road traffic injuries(RTI) in China, so as to provide evidence for the management of traffic safety.

METHODSIndexes as fatalities per 10,000 vehicles, fatalities per 100,000 population, fatalities per 10,000 kilometers, motorization(number of vehicles per 1000 population) and mortal coefficient were used. Clustering analysis and ranking correlation were used to analyze the relative factors.

RESULTSThe number of casualties of RTI had doubled every decade before the year of 2000. One hundred thousand people were killed in RTI every year since 2000. Facts as: Gross National Product(GNP) of China exceeded 1000 USD in 2002, number of motor vehicles reached 1.3 million in 2005, had both influenced the rates of road traffic fatality, mileage fatality and mortal coefficient which causing them to drop since 2002. In China, RTI happened in the underdeveloped districts in the western part of the country including Tibet, Ningxia, Xinjiang, Qinghai, and in some coastal areas as Zhejiang and Guangdong provinces. Men seemed to be more at risk than women in RTI, and accounted for three-quarters of the victims. Majority of fatalities happened in 21-50 year olds and the fatalities among those over 65 year olds had risen every year. The vulnerable populations in road-user category were pedestrians, passengers, motorcyclists and bicyclists. Under most situations, drivers were responsible for RTI and over half of them were professionals. Bad behaviors were the major causes of RTI, including exceeding the speed limit, handle misfeasance, breaking traffic rules and regulation, having taken alcohol or driving with fatigue etc. Exceeding the speed limit was the most risky factor which causing 75% of the RTI and the traffic deaths increased between 2002 to 2004. A positive correlation was discovered between population fatality rate and the factors as the number of vehicles, volume of road haulage, volume of passengers and the degree of highway etc. with correlation coefficients as r1 = 0.986, r2 = 0.986, r3 = 0.987, r4 = 0.985, P = 0.001, respectively.

CONCLUSIONSince 1951, the population fatality rate of RTI had been going up continuously until it began to fall in 2003.

Accidents, Traffic ; mortality ; statistics & numerical data ; China ; epidemiology ; Female ; Humans ; Male ; Wounds and Injuries ; mortality

In order to find the cardiotonic constituents of lateral roots of Aconitum carmichaelii Debx., the investigation was carried out. Silica gel column chromatography, Sephadex LH-20, medium-pressure MCI and reverse phase ODS column chromatography were used to separate the 90% EtOH extract of the lateral roots of Aconitum carmichaelii Debx. The structures of the isolated compounds have been identified by chemical properties and spectroscopic analyses. Ten compounds were isolated and their structures were elucidated as benzoic acid-5-hydroxy-2-benzoyl-amino methyl ester (1), honokiol (2), pinoresinol (3), salicylic acid (4), p-hydroxy-cinnamic acid (5), songorine (6), karakoline (7), mesaconitine (8), hypaconitine (9) and 14-benzoylhypaconitine (10), separetely. Compound 1 is a new compound and its structure has been established by NMR, HR-ESI-MS, UV, IR and X-Ray. Compound 2-5 are isolated from the lateral roots of Aconitum carmichaelii Debx. for the first time.
Aconitum ; chemistry ; Cardiotonic Agents ; chemistry ; isolation & purification ; Plant Roots ; chemistry

Objective To explore the development on infrastructure and professional contingence related to injury prevention and control, in China. Methods 38 Centers for Disease Control and Prevention(CDC)were investigated by using a self designed questionnaire and data was analyzed descriptively. Results At present, all the CDCs at provincial and city level had not set up a specific department related to injury prevention and control, except for Shanghai and Guangxi CDCs.The proportions of full-time and part-time staff in all of the investigated CDCs were 37.30% and 62.70% respectively. From 2005 to 2008, the proportions of CDC which had made funds more than 500 000 Yuan available on injury prevention and control were: 27.78% in the eastern areas, 28.58% in central and 7.69% in the western areas of China. There were 76.92% of the CDCs in the western areas of China that the invested funding was less than 100 000 Yuan in the past years. Most of the routine work that had been carried out in those CDCs were surveillance and public education programs including collection of data and special surveys related to injuries on children, adolescents and the elderly population. 44.44%, and 28.57% of the CDCs in the eastern and central parts of the country wished to establish a Department of injury prevention and control, while 76.92% of the CDCs in the western part expressed their strong request for professional training on injury. Conclusion China remained underdeveloped in the development of institutional and professional team working on injuries which called for, setting up related programs to suit the local needs. In accordance with the working condition, the progress that had been made and the objective demand on institutional and professional contingence of the problems in different areas,both short and medium terms on the issue,need to be put forward to develop both institutional and professional programs on injuries in the eastern, central, and western areas of China.

OBJECTIVETo explore the relationship of aging with the changes of endogenous carbon monoxide (CO), cGMP and cAMP contents in the penile tissues of rats.

METHODSTwenty-four male rats were equally divided into an 8-month, a 16-month and a 24-month group, and their penile erection was detected by injecting apomorphine, their penile cavernous body harvested, and the contents of CO, cAPM and cGMP detected by improved dual wavelength spectrophotometry.

RESULTSThe contents of CO, cAPM and cGMP were reduced with the increase of age, with statistically significant differences between the three age groups (P < 0.01).

CONCLUSIONAging significantly decreased the contents of CO, cAMP and cGMP in the penile tissues of the rats, which suggests that aging might play an important role in erectile dysfunction.

Aging ; physiology ; Animals ; Carbon Monoxide ; metabolism ; Cyclic AMP ; metabolism ; Cyclic GMP ; metabolism ; Male ; Penis ; metabolism ; Rats ; Rats, Wistar

OBJECTIVETo explore the incidence and risk factors of campus violence in Guangzhou.

METHODS2200 college students in three universities in Guangzhou were selected by cluster sampling method and were interviewed with self-designed questionnaire about the incidence and risk factors of campus violence in 2010. The final analysis sample was 2103. Chi-square test was used to analyze the gender, grade and major distribution of campus violence. Logistic regression method was used to analyze the influencing factors of campus violence in bully and victim.

RESULTSThe incidence of campus violence in Guangzhou was 69.9% (1471/2103). In boys and girls the incidence of campus violence was 75.6% (830/1098) and 63.8% (641/1005) (&chi;(2) = 34.82, P < 0.05). The incidence of bully and victim of campus violence was 63.6%(1338/2103) and 55.3% (1163/2103). The incidence of bully and victim in boys was 70.9%(778/1098) and 60.0%(659/1098), and in girls was 55.7% (560/1005) and 50.1% (504/1005) (&chi;(2)(bully) = 51.93, &chi;(2)(victim) = 20.68, P < 0.01). The incidence of psychological violence was the highest (68.0%, 1430/2103), followed by sexual violence (34.2%, 719/2103), the incidence of physical violence was the lowest (16.5%, 348/2103). Results of logistic regression showed that boys (OR = 1.60), arts (OR = 1.82), with siblings (OR = 1.31), the living expenses was not enough (basic enough OR = 1.35, not enough OR = 1.54), playing the computer games (OR = 1.70), playing tricks such as sliding plate (OR = 2.03), loving violence program (general OR = 1.30, very like OR = 1.44), mother with gamble behavior (OR = 4.29), father's indulgent education style (OR = 1.60), been bullied by others before high school (OR = 1.61), dissatisfaction to the environment and rules of campus (nothing special feeling OR = 1.67, some dissatisfaction OR = 1.89), been treated badly by primary school teacher (one kind OR = 1.35, two kinds and above OR = 1.90)were the risk factors of bully. Boys (OR = 1.23), minority (OR = 1.71), with siblings (OR = 1.39), bad behavior and habit (OR = 1.32), the bad family economic conditions (general OR = 1.51, difficult OR = 1.88), mother with gamble behavior (OR = 2.33), father's indulgent education style (OR = 1.37), occasional physical punishment by mother (OR = 1.35), been bullied by others before high school (sometimes OR = 1.61, often OR = 1.85), high pressure during the study (a little high OR = 1.37, very high OR = 1.40), dissatisfaction to the environment and rules of campus (some dissatisfaction OR = 1.56, completely dissatisfaction OR = 2.04), been treated badly by primary school teacher (one kind OR = 1.70, two kinds and above OR = 2.04)were the risk factors of being victim.

CONCLUSIONThe campus violence in Guangzhou is serious, especially the psychological violence and sexual violence. And the risk factors of campus violence in bully and victim are multifold.

Adolescent ; Adult ; China ; Female ; Humans ; Incidence ; Logistic Models ; Male ; Risk Factors ; Students ; psychology ; Surveys and Questionnaires ; Universities ; Violence ; statistics & numerical data ; Young Adult

OBJECTIVETo explore the relationship between secular trend of road traffic injuries (RTI) and gross domestic product (GDP) per capita in China.

METHODSStatistical description was used in the data about cases, injuries, deaths, mileage mortality and 10 million population mortality from 1970 to 2009. Cluster analysis was used to classify the 31 provinces, municipalities and autonomous regions in China. Ecological study was used to explore the relationship between RTI and GDP per capita.

RESULTSThere were three stages of RTI in China. It grew rapidly in 1970 - 2002 (from 1.16 to 8.52 per 10 million population), kept steady in 2003 - 2004 (from 8.08 to 8.24 per 10 million population), and decreased obviously in 2005 - 2009 (from 7.55 to 5.08 per 10 million population). The ecological study showed that the population mortality of RTI rose along with the GDP per capita's growth. When the GDP per capita reached to 14 053 yuan (equivalent to 1716 US dollar, in 2005), the mortality began to decrease obviously, the average annual decreasing rate was 10.16%(8.14% - 10.52%)in the following five years. According to the GDP per capita during the period of 1999 - 2009, the 31 provinces, municipalities and autonomous regions in China were divided into three categories of region. The curves of population mortality of RTI and GDP per capita in different category possessed the same ecological trend. That was the population mortality early rose and then fell along with the GDP per capita's growth. All of they started to decrease obviously in 2005. The GDP per capita among three categories of region was different (45 281 yuan, 22 243 yuan and 10 475 yuan respectively) in the same period.

CONCLUSIONIn the early stage of economic development, the mortality of RTI increased along with the economic development. When the economic development reached a certain level, the mortality decreased along with the GDP per capita's growth.

Accidents, Traffic ; trends ; China ; Economics ; Gross Domestic Product

OBJECTIVETo evaluate the influence of the surveillance system and preventive measurements on the control of severe acute respiratory syndrome (SARS) in a university in Guangdong Province.

METHODSA university with more than thirty thousand undergraduates, staff and their relatives was retrospectively studied, from which information regarding the status of epidemic, organization of leadership, disease control strategies and measures were collected and analyzed.

RESULTSThe construction of the surveillance system in such a model as "individual-dormitory/home-class/unite-faculty and institute-university" largely contributed to the achievement of the goals of low incidence, no secondary, no epidemic, and no death. A series of control measures benefited the early diagnosis, effective isolation, prevention, and treatment of SARS control.

CONCLUSIONSARS could be effectively controlled in university only if strict surveillance system is built up, and all-round preventions, including early isolation of both confirmed or suspected cases and close contacted persons, are carried out.

Adolescent ; Adult ; China ; Communicable Disease Control ; methods ; Female ; Humans ; Male ; Population Surveillance ; methods ; Severe Acute Respiratory Syndrome ; prevention & control ; Universities

OBJECTIVETo investigate the expression characteristics of the gene of coiled-coil domain-containing protein 70 (Ccdc70) in the mouse testis and its potential role in spermatogenesis.

METHODSUsing expression profile microarray, we screened the mouse testis-specific gene Ccdc70, studied its expression characteristics in the mouse testis by RT-PCR, real-time PCR, Western blot and immunohistochemistry, followed by bioinformatic analysis of the Ccdc70 protein.

RESULTSThe Ccdc70 gene was expressed highly in the testis but lowly in the epididymis of the mice. The Ccdc70 protein was expressed mainly in the spermatocytes and round spermatids of the testis and in the epithelial cells of the epididymis. Bioinformatic analysis showed a structural domain in the Ccdc70 protein, which was highly conserved in mammalian evolution.

CONCLUSIONThe Ccdc70 gene is highly expressed in the mouse testis and mainly in the spermatocytes, round spermatids, and epididymal epithelial cells, which indicates that it is involved in the regulation of spermatogenesis and epididymal sperm maturation.

Animals ; Computational Biology ; Gene Expression Regulation, Developmental ; Male ; Mice ; Proteins ; genetics ; Spermatogenesis ; genetics ; Testis ; metabolism

Objective To investigate the occurrence,distribution and risk factors of mobile phone dependence syndrome (MPDS) among college students in Guangzhou.Methods A unified questionnaire was adopted,with 2311 college students from 6 universities in Guangzhou investigated by cluster sampling.Distribution and risk factors of MPDS among different groups were analyzed by logistic regression.Results A total number of 2213 effective questionnaires was retrieved,including 1149 males and 1064 females.The average age was (21.33 ± 1.72).The incidence rate of MPDS among studied college students in Guangzhou was 23.3％ (515/2213).Regarding the distribution of personal characteristics,significant differences were found in the following aspects:grades,majors in college,being the only child of the family,monthly cost of living,personal characters and the academic performance at school (P＜0.05).Regarding the distribution of characteristics among parents,significant differences were found in the following areas:educational levels of the mother,rearing patterns of both parents,status of feeling on mother's caring (P＜0.05) etc.The main risk factors for MPDS were as follows:students majored in literature and law,with high monthly living cost,father' s autocratic and democratic patterns of rearing,mother' s autocratic and doting rearing pattern as well as personal feeling on mother's attitude of unconcern.The incidence of MPDS among those persons with uncertain characters was less than those who were extroverts.Conclusion MPDS among college students seemed to be severe in Guangzhou.No difference was found in the incidence rates of MPDS between genders.Should take interventions according to its risk factors.