1.Predictors of neurologic handicap in hypoxic ischemic encephalopathy.
Seung Tae KIM ; Gui Ran KIM ; Byung Hak LIM ; Sang Geel LEE ; Im Ju KANG
Journal of the Korean Pediatric Society 1991;34(4):473-479
No abstract available.
Hypoxia-Ischemia, Brain*
2.A Case of Spontaneous Gastric Perforation in the Newborn.
Ran SUH ; Gui Sook CHOI ; Hye Lyung BAIK ; Hyo Jung KIM ; Sung Woo SHIN
Journal of the Korean Pediatric Society 1985;28(6):587-592
No abstract available.
Humans
;
Infant, Newborn*
3.Malignant Mesenchymoma of the Right Axillary Area: A case report.
Sung Ran HONG ; Gui Ohk YOON ; Seong Sook KIM ; Hye Jae CHO ; Il Hyang KO
Korean Journal of Pathology 1986;20(1):107-111
The term malignant mesenchymoma has been applied to those tumors of the soft tissue of mesenchymal origin which are composed of tumor cells differentiating into two or more unrelated malignant forms in addition to the fibrosarcomatous element. Recently authors experienced a case of malignant mesenchymoma in the right axillary area. Microscopically the sarcoma revealed multiple pattern of differentiation, including liposarcoma, malignant schwannoma, fibrosarcoma, malignant fibrous histiocytoma and rhabdomyoblastoma. The presence of rhabdomyblastic cells were proved by immunochemical study utilizing desmin. This patient was treated with surgical excision and radiation.
4.A Case of Esophageal Atresia with Tracheoesophageal fistula.
Ran SUH ; Hye Kyung LEE ; Gui Sook CHOI ; Hyo Jung KIM ; Sung Woo SHIN
Journal of the Korean Pediatric Society 1984;27(10):1006-1010
No abstract available.
Esophageal Atresia*
;
Tracheoesophageal Fistula*
5.Detection of antigen of RSV and clinical considerations on epinephrine response in wheezy infancy.
Gui Ran KIM ; Seoung Tae KIM ; Hyang Suk HYUN ; Sang Geel LEE ; Im Ju KANG ; Sei Yun JUNG
Journal of the Korean Pediatric Society 1991;34(3):388-397
No abstract available.
Epinephrine*
6.Detection of antigen of RSV and clinical considerations on epinephrine response in wheezy infancy.
Gui Ran KIM ; Seoung Tae KIM ; Hyang Suk HYUN ; Sang Geel LEE ; Im Ju KANG ; Sei Yun JUNG
Journal of the Korean Pediatric Society 1991;34(3):388-397
No abstract available.
Epinephrine*
7.Effect of aldosterone on the amplification of oncolytic vaccinia virus in human cancer lines.
Hyun Ju LEE ; Jasung RHO ; Shao Ran GUI ; Mi Kyung KIM ; Yu Kyoung LEE ; Yeon Sook LEE ; Jeong Eun KIM ; Euna CHO ; Mong CHO ; Tae Ho HWANG
The Korean Journal of Hepatology 2011;17(3):213-219
BACKGROUND/AIMS: JX-594 is an oncolytic virus derived from the Wyeth vaccinia strain that causes replication-dependent cytolysis and antitumor immunity. Starting with a cross-examination of clinical-trial samples from advanced hepatocellular carcinoma patients having high levels of aldosterone and virus amplification in JX-594 treatment, we investigated the association between virus amplification and aldosterone in human cancer cell lines. METHODS: Cell proliferation was determined by a cell-counting-kit-based colorimetric assay, and vaccinia virus quantitation was performed by quantitative polymerase chain reaction (qPCR) and a viral plaque assay. Also, the intracellular pH was measured using a pH-sensitive dye. RESULTS: Simultaneous treatment with JX-594 and aldosterone significantly increased viral replication in A2780, PC-3, and HepG2 cell lines, but not in U2OS cell lines. Furthermore, the aldosterone treatment time altered the JX-594 replication according to the cell line. The JX-594 replication peaked after 48 and 24 hours of treatment in PC-3 and HepG2 cells, respectively. qPCR showed that JX-594 entry across the plasma membrane was increased, however, the changes are not significant by the treatment. This was inhibited by treatment with spironolactone (an aldosterone-receptor inhibitor). JX-594 entry was significantly decreased by treatment with EIPA [5-(N-ethyl-N-isopropyl)amiloride; a Na+/H+-exchange inhibitor], but aldosterone significantly restored JX-594 entry even in the presence of EIPA. Intracellular alkalization was observed after aldosterone treatment but was acidified by EIPA treatment. CONCLUSIONS: Aldosterone stimulates JX-594 amplification via increased virus entry by affecting the H+ gradient.
Aldosterone/*pharmacology
;
Aldosterone Antagonists/pharmacology
;
Amiloride/analogs & derivatives/pharmacology
;
Animals
;
Carcinoma, Hepatocellular/blood/virology
;
Cell Line, Tumor
;
Humans
;
Hydrocortisone/blood
;
Hydrogen-Ion Concentration
;
Liver Neoplasms/blood/virology
;
Neuroprotective Agents/pharmacology
;
Oncolytic Virotherapy
;
Rabbits
;
Spironolactone/pharmacology
;
Vaccinia virus/*drug effects/genetics/metabolism/*physiology
;
Virus Replication/*drug effects
8.Clinical Competency for Directing of Registered Nurses's National Examination: focused on Fundamental, Medical-Surgical, Psychiatric, women's health, community, Pediatric, and Administrative Nursing.
Boon Han KIM ; SoYaJa KIM ; Jeong Seop LEE ; Young Ran TAK ; Hee Soon KIM ; Ee Soon CHOI ; Kyoung Rim SHIN ; Kyoung Sook CHOI ; Gui Boon KIM ; Gwang Joo KIM ; So Woo LEE ; Kem Soon KIM ; Sook Ja LEE ; Yun Hee KIM ; Kyoung Hea LEE ; Young Sook JEONG ; Ji Ho SONG ; Jeong Ho PAK
Journal of Korean Academy of Nursing 1998;28(4):1075-1087
For producing large numbers of professional nurses who could manage 21th century's human health, it is necessary to review the direction of registered nursed' national examination which evaluates the nursing education and is granted a licence. For adapting to social expectation of the nurse, we have to nurture the nurses' problem solving capability in clinical setting. Seven divisions of Korean Academy of Nursing suggested clinical competency according to their categories. This paper was presented in the workshop for setting up direction of registered nurses' national examination. We expect that this paper would be more refine and confirm through reviewing subdivisions' learning objectives and discussing clinical minimum level of competence contents with clinical leaders.
Education
;
Education, Nursing
;
Financing, Organized
;
Humans
;
Learning
;
Mental Competency
;
Nursing*
;
Problem Solving
;
Women's Health*
9.The Efficacy of Fetal Ultrasonography and Postnatal Abdominal Ultrasonography for the Diagnosis of Neonatal Abdominal Mass.
Hee Eun LEE ; Ee Kyung KIM ; Hee Seok KIM ; Yun Kyoung LEE ; Chan Hwu PARK ; Kyung Ran PARK ; June Dong PARK ; Beyong Il KIM ; Woong Heum KIM ; Jung Hwan CHOI ; Gui Won PARK ; Hwang CHOI ; Yong CHOI ; Woo Ki KIM ; Chong Ku YUN
Journal of the Korean Pediatric Society 1998;41(3):299-306
PURPOSE: Most neonatal abdominal masses are benign in nature, but early detection and management is important to avoid the development of complications. So, we studied the causes of neonatal abdominal masses and the efficacy of ultrasonography for early detection and diagnosis. METHODS: We reviewed 36 newborn infants with abdominal masses who had been admitted to the nursery and Neonatal Intensive Cave Unit of Seoul National University Children' s Hospital from Jan. 1, 1989 to Dec. 31, 1995. RESULTS: The mean gestational age was 38 weeks and the male to female ratio was 22 : 14. All masses were benign and the most common etiology was hydronephrosis (41.7%). The following etiologies were multicystic dysplastic kidney, polycystic kidney, ovarian cyst, hemangioendothelioma, teratoma, meconium peritonitis, mesenteric cyst and intestinal duplication cyst. All except one were detected before the first 48hours, and among them, 32 cases (88.9%) detected antenatally. All patients except one who died shortly after birth, were examined by abdominal ultrasonography, and 31 of 35 masses (88.6%) had the same diagnosis of ultrasonography. Five cases had associated abnormalities in the opposite kidney and other organs. CONCLUSION: The most common etiology of neonatal abdominal masses was hydronephrosis and majority of masses originated from genitourinary system. Most abdominal masses were detected antenatally and abdominal ultrasonography was an efficient method for the diagnosis of neonatal abdominal masses.
Diagnosis*
;
Female
;
Gestational Age
;
Hemangioendothelioma
;
Humans
;
Hydronephrosis
;
Infant, Newborn
;
Kidney
;
Male
;
Meconium
;
Mesenteric Cyst
;
Multicystic Dysplastic Kidney
;
Nurseries
;
Ovarian Cysts
;
Parturition
;
Peritonitis
;
Polycystic Kidney Diseases
;
Seoul
;
Teratoma
;
Ultrasonography*
;
Ultrasonography, Prenatal*
;
Urogenital System
10.Adenocarcinoma of unknown primary site.
Seo Young SONG ; Won Seog KIM ; Hye Ran LEE ; Hyun Sik JEONG ; Nam Su LEE ; Sung Yong OH ; Ji Hyang KIM ; Kihyun KIM ; Eun Mi NAM ; Young Ryun OH ; Chul Won JUNG ; Sung Soo YOON ; Young Hyuck IM ; Hong Gui LEE ; Won Ki KANG ; Chan Hyung PARK ; Keunchil PARK
Korean Journal of Medicine 2001;61(3):234-239
BACKGROUND: To study clinical characteristics and treatment outcomes of adenocarcinoma of unknown primary site (ACUPS). METHODS: A retrospective analysis of 81 patients who were diagnosed as ACUPS, seen at Samsung Medical Center from May, 1995 to July, 1999, was performed. RESULTS: The median age of the patients was 58 years. The common sites of metastases were the lymph node, liver, lung, bone. In 49 of 81 patients (60.5%), the dominant tumor location was below the diaphragm. The majority of patiens (76 of 81) were initially treated with systemic chemotherapy including cisplatin. Responses were evaluable in 70 of 76. Eighteen of 70 patients (25.7%) responded to chemotherapy and complete remission was observed in 6 patients. The overall median survival of 81 patients was 5.6 months. The median survival of the responding patients was 18.3 months but the median survial of the nonresponding patients was 4.6 months (p<0.01). In univariate and multivariate analysis, age, performance status and response to initial chemotherapy were significant prognostic factors for overall survial. CONCLUSION: Poor survival rate and treatment response were observed in ACUPS but complete response and long-term survival were observed in several patients.
Adenocarcinoma*
;
Cisplatin
;
Diaphragm
;
Drug Therapy
;
Humans
;
Liver
;
Lung
;
Lymph Nodes
;
Multivariate Analysis
;
Neoplasm Metastasis
;
Retrospective Studies
;
Survival Rate