Alprostadil ; administration & dosage ; adverse effects ; Drugs, Chinese Herbal ; administration & dosage ; adverse effects ; Humans ; Injections, Intravenous

Nicotinamide N-methyltransferase (NNMT) is a S-adenosyl-L-methionine (SAM) dependent cytoplasm enzyme,which plays a vital role in the biotransformation and detoxification of many drugs and xenobiotic compounds.Recent studies have revealed abnormal expression of NNMT in many tumors,which may contribute to tumorigenesis and tumor development and radiotherapy or chemotherapy resistance.

Adolescent ; Child ; Child, Preschool ; Female ; Guillain-Barre Syndrome ; blood ; Humans ; Immunologic Factors ; blood ; Interleukin-13 ; blood ; Interleukin-18 ; blood ; Male

Objective To study the effects of Alprosladil and Glutathione therapy on patients with drug-induced acute renal damage. Methods 108 patients with drug-induced acute renal damage were divided into three groups at random. The patients in gruoup A (n=36) received 10?g Alprosladil injection once a day, the patients in group B (n=42) received both 10?g alprosladi and 1200mg glutathione injection once a day additionally, and the patients in group C (n=30) received 10mg dpamine injection once a day. The course of treatment of the three groups was 2～4 weeks. Results The effective rates for acute renal failure in groups A, B and C were 85 7%, 96% and 61% respectively. The effective rates for proteinuria, hematuria, N-acetyl-?-glucosaminidase(NAG)and retinol-binding protein(RBP) in urine were 70%, 78%, 76% and 80% in group A, 85%, 90%, 90% and 90% in group B, and 50%, 50%, 42% and 58% in group C respectively, which had significant difference among the three groups (P

Objective To predict the pharmacological effect and targets of main chemical components of Lindera aggregata, and construct the multi-target network. Methods The potential targets and pathways of linderene acetate, isocembrol, laurolitsine, β-humulene, chamazulene, laurotetanine, and lindestrenolide, selected as the representative compounds of oils, alkaloids, and furan sesquiterpene lactones from Linderae Radix, were predicted by methods of network pharmacology. The pharmacodynamic effects of main chemical constituents of L. aggregata was analyzed by data integration. Results The in silico prediction results showed that seven compounds of L. aggregata affected 20 related pathways through 40 potential targets. The pathways were involved in several links including inflammatory, analgesic, gastrointestinal movement regulation, anti-oxidation, antitumor, liver injury protection, and immunoregulation. The various components showed common targets, pathways, and pharmacodynamic effects and had different emphases. Conclusion The pathways related to L. aggregata oils, alkaloids, and furan sesquiterpene lactones were connected by the common targets, showing the synergistic effect of different compounds by acting on multi-targets and multi-pathways. This study provides references for systematic exploration on the pharmacological actions and mechanisms of L. aggregata.

This paper mainly discussed a bacterial stain with high flocculating activity isolated from cantaloupe juice .The strain was named Bacillus sp.B_(53) based on colony morphology, physiological and biochemistry experiments. The new flocculant was purified and shown to be a homopolymer of glutamic acid by HLPC analysis and thin layer chromatography, and presumed to be Poly ?-glutamic acid(?-PGA). ?-PGA 12.48g/L was achieved in shake flask. The purified material showed a absorption peak at 212nm, and was only composed of L-Glu. The MW could be detected through SDS-PAGE, and its MW was about a molecular mass between 440kD with 669kD. This bioflocculant efficiently flocculated various organic and inorganic suspensions. It's flocculanting effect on kaolin and ([BF]Ca(OH)_2[BFQ]) was superior to others.

This paper mainly discusses the purpose , content , organization of the curriculum design of fermentation engineering and equipment and the teching importance to bioengineering major.

Background Rare studies on the effect of statin on early stage of atherosclerosis have been repor- ted.Oxidative stress induced endothelial dysfunction may be the initiative factor for the development of atheroscle- rotic plague.Objective To investigate the mechanisms by which simvastatin,prevents atheroselerosis independ- ently of its lipid-lowering effect in Apolipoprotein E deficient mice.Methods Twenty-four 6 week old male apoE- deficient mice were randomly to receive placebo or simvastatin 5 mg/(kg?d)by gavage for 4 weeks.Total choles- terol(TC),super oxide dismutase(SOD),malondialdehyde(MDA)and serum nitric oxide(NO)were measured by biochemical analysis.Endothelium was observed by HE dyeing.The expression of caveolin-1 in aortic wall was detected by immunohistochemistry.Results There was no significant difference in serum TC between control and simvastatin treatment groups.Simvastatin caused less damaged endothelium(33.33% vs control's:75%,P

AIM: To evaluate the efficacy and complications of intravitreal injection of triamcinolone acetonide ( TA ) for the treatment of macular edema caused by pre-retinal membrane of the macular.
METHODS: Totally 23 patients ( 24 eyes ) with macular edema caused by pre-retinal membrane of the macular were treated withintravitreal injection of 4mg TA. Best-corrected visual acuity ( BCVA ) , intraocular pressure ( IOP ) , slit - lamp examination, fundus fluorescein angiography ( FFA ) and optical coherence tomography (OCT) were performed before and after treatment. The SPSS 12. 0 software was used for statistical analysis.
RESULTS: After 10, 30, 90d of treatment of TA, as compared with before treatment, visual acuity improved significantly ( P<0. 05 ), and central macular thickness (CMT) was significantly thinner (P<0. 01). The average central macular thickness decreased from 522 ± 126μm before treatment to 264±115μm, 245±128μm, 286±131μm at 10, 30, 90d after treatment. Macular edema reduced. IOP increased in 7 eyes ( 29%) , one cataract case, no other complications associated with vitreous injection.
CONCLUSION: Intravitreal injection of TA in the treatment of macular edema caused by pre - retinal membrane of the macular is simple, safe and easy to operate. It can quickly reduce macular edema, and improve the visual acuity in the short term. Part of patients may recur after injection in the first half of the year.