Objective To investigate the characteristics of lymph node metastasis in T 1 stage of lung cancer and the curative effects of minimally invasive surgery and open surgery .Methods Totally 120 cases of T1 stage of lung cancer were divided into two groups ,68 cases in the minimally invasive surgery group and 52 cases in the open surgery group ,the number of lymph node me‐tastasis in the patients with lung cancer in T 1 stage were studied ,the perioperative related indicators for different tumor size were compared between the two different surgical methods .Results All patients were successfully completed the operation without op‐erative death case .The two groups had no significant difference in the aspects of operation time ,intraoperative bleeding volume and number of lymph node dissection .The lymph node metastasis rates in the maximum tumor diameter ≤1 .0 ,1 .0 -3 .0 cm were 1 .3% and 9 .7% respectively .N1 ,N2 squamous cancer of the maximal tumor diameter ≤1 .0 cm had no metastasis .The periopera‐tive related clinical indicators in the maximal tumor diameter ≤1 .0 cm had significant differences between the two kinds of opera‐tion method(P<0 .05) ,the perioperative related clinical indicators in the maximal tumor diameter 1 .0-3 .0 cm had no significant differences between the two kinds of operation method .Conclusion The patients with T1 stage of lung cancer and the maximal tumor diameter ≤1 .0 cm are more suitable for the minimally invasive surgery ,but the patients with T1 stage of lung cancer and the maximal tumor diameter>1 .0 cm have little difference in minimally invasive surgery and open surgery .

Objective To investigate changes of peripheral blood eosinophils(EOS),D-dimer(D-D)and neutrophil/lymphocyte ratio(NLR)in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)and their relationship with pulmonary ventilation function.Methods Sixty-five AECOPD patients(the observation group)and 65 COPD patients(the control group)were selected respectively and included in this study.Basic data were collected in the two groups of patients,and laboratory indexes were examined.EOS and D-D levels were determined,and NLR was calculated.The lung function indexes including the first second expiratory volume with exertion(FEV1),the first second expiratory volume with exertion as a percentage of expiratory lung capacity with exertion(FEV1/FVC),and blood gas indexes of arterial blood partial pressure of oxygen[p(O2)]and arterial blood partial pressure of carbon dioxide[p(CO2)]were detected.Multifactorial Logistic regression was used to analyze the influencing factors of AECOPD.The nomogram model of AECOPD was established and verified by R4.2.3.Results Compared with the control group,levels of EOS,D-D and NLR were elevated,and FEV1 and FEV1/FVC levels were reduced in the observation group(P＜0.05).Multifactorial Logistic regression analysis showed that elevated EOS,D-D and NLR,and reduced FEV1/FVC and FEV1 were independent risk factors for patients with AECOPD(P＜0.05).The area under the receiver operating characteristic(ROC)curve of AECOPD nomogram model was 0.817(95%CI:0.784-0.904),and the Hosmer-Lemeshow test showed goodness of fit of the model(χ2=4.320,P＞0.05).EOS,D-D and NLR were positively correlated with FEV1 and FEV1/FVC(P＜0.05).Conclusion The elevated levels of EOS,D-D and NLR are risk factors that affect pulmonary ventilation in AECOPD patients,which can be used as an important indicator to evaluate pulmonary ventilation function.