Objective To explore the predictive value of spleen?liver volume ratio( SLVR) on the prog?nosis of partial hepatectomy in patients with hepatocellular carcinoma. Methods Clinical data of 86 cases of hepatocellular carcinoma underwent hepatectomy who were treated in the Traditional Chinese Medicine Hospital of Guangzhou from January 2009 to December 2014 were analyzed retrospectively. According to the preoperative spleen?liver volume ratio,these patients were divided into 2 groups:those with SLVR<0. 8 as low SLVR group with 44 cases, and SLVR ≥0. 8 as high SLVR group with 42 cases. Patients were followed?up until June 2015. Cox ratio risk pattern analysis was used for the recurrent correlative factors. Results The 1,3,5 year sur?vival rates of low SLVR group were 95. 5%, 88. 6%, 81. 8%, of the high SLVR group were 73. 8%, 47. 6%, 40. 5%,the differences between two group were statistically significant (χ2 = = 10. 223, 16. 098, 18. 010, P<0. 05) . Univariate analysis showed that,the maximum diameter of the tumor>5 cm,the number of tumor>3,por?tal vein or hepatic vein tumor thrombus,preoperative AFP?L3%≥10%,the rate of Invasion of blood vessels and the percentage of positive margins of high SLVR group all significantly lower than that of low SLVR group (25. 0%(11/44) vs. 59. 5%(25/42),22. 7%(10/44) vs. 54. 8%(23/42),9. 1%(4/44) vs. 26. 2%(11/42),38. 6%(17/44) vs. 78. 6%(33/42),18. 2%(8/44) vs. 38. 1%(16/42),2. 3%(1/44) vs. 14. 3%(6/42);χ2=20. 645,16. 180,24. 728,4. 819,18. 402,20. 105;P<0. 05) . Cox regression analysis revealed that di?ameter of the tumor>5 cm,SLVR ≥0. 8,AFP?L3≥10%,and portal vein or hepatic vein tumor thrombus were independent predictors of poor disease?free survival after hepatectomy for hepatocellular carcinoma( Or=6. 141, 3. 753,6. 968,7. 763;P<0. 05). Conclusion Preoperative SLVR ≥0. 8 is an independent adverse predictor of poor disease?free survival,can preliminarily predict the prognosis of patients with hepatocellular carcinoma.

Objective To compare and analyze the short-term efficacy of modified intermediate laparoscopic right hemicolectomy (LRHC) and traditional intermediate laparoscopic right hemicolectomy (LRHC) in patients with colon cancer.Methods Eighty-four patients with colon cancer treated by laparoscopic right hemicolectomy (LRHC) from March 2014 to March 2018 in the General Surgery department of Guangzhou Hospital of Traditional Chinese Medicine were randomly divided into two groups.The control group was treated with traditional intermediate approach,while the improved group was treated with improved intermediate approach centering on the anterior pancreatic head region,with 42 cases in each group.The two groups of operations and related complications were statistically analyzed and compared.Results Compared to the control group,the improved group had less estimated mean blood loss ((39.5± 11.6) ml vs.(86.3± 13.7) ml,t =11.124,P＜0.05),shorter operative time((104.5±20.5) min vs.(139.3±25.9) min,t =6.094,P＜0.05) and lower intraoperative vascular damage rate (7.1％ (3/42) vs.23.8％ (10/42),x2=7.406,P＜0.05).There were no significant differences in the number of conversion to laparotomy,number of harvested lymph node,postoperative complications,hospital stay and quality of postoperative specimens between the two groups (P＞ 0.05).Conclusion Modified intermediate approach LRHC for colon cancer patients not only reduces the amount of bleeding and operation time,but also significantly reduces the rate of intraoperative vascular injury.

Osteosarcoma is the most common primary malignant bone tumor, yet treatment modalities and patient outcomes have remained relatively stagnant over the past three decades. Recently, with increasing insights into the molecular characteristics of osteosarcoma, targeted therapies, such as tyrosine kinase inhibitors and cell cycle-related inhibitors, have shown significant progress in both preclinical studies and clinical trials. Checkpoint kinase 1 (CHEK1), a key player in DNA damage response, is involved in various critical biological functions, and the development of its specific inhibitors has gained attention in multiple fields of cancer treatment. Osteosarcoma, comprising multiple subtypes with distinct alterations in cell cycle and DNA damage response mechanisms, particularly exhibits increased sensitivity to CHEK1 inhibitors in p53 mutant cells. Targeting the CHEK1-associated pathway holds promise for improving patient outcomes. Inhibition of ataxia telangiectasia mutated (ATM) and/or ataxia telangiectasia and Rad3-related (ATR) pathways impairs DNA damage repair in osteosarcoma cells, identifying downstream molecules linked to CHEK1 as potential therapeutic targets. Suppression of CHEK1 activity leads to downregulation of related protein expression and inhibits cell proliferation and repair processes, an effect that is notably enhanced when combined with chemotherapeutic agents. Although single-agent chemotherapy often produces limited results, the use of CHEK1 inhibitors such as Prexasertib enhances cytotoxic effects against osteosarcoma cells, either as monotherapy or in combination regimens, demonstrating robust efficacy. Co-administration of CHEK1 inhibitors with other cell cycle modulators or downstream target antagonists could further optimize treatment outcomes. Furthermore, modulating DNA damage response pathways may have implications for immunotherapy. This review systematically summarizes recent research on the CHEK1-related pathway in osteosarcoma and emphasizes that targeting the DNA damage response pathway related to CHEK1 may be a promising strategy for osteosarcoma treatment with broad prospects.

Objective : To explore the relationships among pharyngeal airway morphology, craniocervical posture, and anterior teeth position in hyperdivergent skeletal Class Ⅱ female adults and provide a reference for orthodontic clinical diagnosis and treatment. Methods: Lateral cephalometric radiographs of 104 untreated skeletal Class Ⅱ (ANB ≥ 4.7°) female adults were included and divided into a hyperdivergent group (MP-SN ˃ 37°) (n = 52) and a normodivergent group (29° ≤ MP-SN ≤ 37°) (n = 52) by mandibular plane angle. The pharyngeal airway sagittal size, craniocervical angulation and anterior teeth position of the two groups were measured. Results : Compared to the normodivergent group, hyperdivergent subjects exhibited narrower nasopharyngeal, velopharyngeal, and glossopharyngeal airways (P<0.05) and larger craniocervical angulations (P<0.05). In the hyperdivergent group, the nasopharyngeal airway sagittal size was negatively correlated with craniocervical angulations (P<0.05), while the hypopharyngeal airway sagittal size was positively correlated with craniocervical angulations in the hyperdivergent group and normodivergent group (P<0.05). In both groups, craniocervical angulations were negatively related to the labiolingual inclination of the upper incisors (P<0.05) but positively related to the inclination of the occlusal plane (P<0.05). Conclusion Hyperdivergent skeletal Class Ⅱ female adults had narrower upper airways and more extended craniocervical posture, which was correlated with pharyngeal airway morphology and anterior teeth position simultaneously. These results suggested that there were correlations among respiratory efficiency, craniocervical posture and dentofacial morphology.