In this paper are reported the creep experiment al studies on 9 fresh C5.6 intervertebral discs,9 fresh T6.7 interverteb ral discs and 10 L4.5 intervertebral discs that were taken from the bodies of ten men(aged 19-35 years)who had died of head injury 1-4 h before. By simulating t he temperature of human body (36.5℃±0.5℃) and putting 300N load on the discs , we measured the intervertebral creep effects and obtained the strain-time cur ves.

Aluminum is a light metal which is rich in the earth's crust and widely used. Recently, the adverse health effects of environmental and occupational aluminum exposure on human have attracted more and more attention. Aluminum exposure has toxic effects on the central nervous system and is believed to be closely related to the development and progression of Alzheimer's disease. The neurotoxic mechanism of aluminum is complex, especially the role of regulated cell death (RCD) in aluminum-induced neuronal death remains to be further studied. RCD refers to all modes of cell death regulated by multiple intracellular signal transduction pathways under physiological and pathological conditions, including apoptosis, necroptosis, autophagy, pyroptosis, and ferroptosis. This review summarized the morphological characteristics and mechanisms of each RCD mode in the process of aluminum-induced neuronal death, and discussed the relationship and transformation between different RCD modes, providing a new scientific basis for future studies on the treatment and intervention of neurotoxicity induced by aluminum exposure.