Objective To study the CT features and enhance the knowledge of peripheral primitive neuroectodermal tumors(pPNETs). Methods The CT appearances of 6 patients with pPNETs pathologically proved were analyzed retrospectively. Results The CT findings of 5 bone pPNETs were soft mass of homogeneous or heterogeneous density and osteolytic destruction without osteosclerosis, periosteum reaction and tumor bone formation. Follow up CT showed the mass shrunken significantly after radiotherapy in one case. In 1 patient of chest Askin tumor, the lesion appeared as a vast heterogeneous soft mass with moderate inhomogeneous enhancement. The mass invaded mediastinum and local bone destruction were not detected. Four months after operation, a small homogeneous tumor occurred in right chest wall with moderate homogeneous enhancement. Conclusion The manifestations of pPNETs on CT have no characteristics. However, CT can show the intra tumor structures and the extent of the tumor very well, which is helpful in differentiating diagnosis,predicting resectability, detecting distant metastases and evaluating the response to treatment.

Objective To analyse CT signs of giant cell tumor of bone.Methods CT appearances of 42 cases of giant cell tumor of bone were reviewed.All patients were pathological proven.Results (1)Two kinds of bone destruction were seen in all ases:expansive cystic destruction and osteolytic destruction.The anterior was predominantly.(2)Most of our patients haven't bone septations in their tumors (95.2%).(3)Bone crests were usually seen in our study(63.2%).(4)Complete or incomplete sclerotic borders existed in 44.7% of all cases.(5)The inner bone soft tissues were heterogeneously in most of the patients.Fluid-fluid level can be seen in 5 cases (11.9%).(6)The outer-bone soft tissue masses were demonstrated in the majority cases with discontinuous bone shell.Conclusion CT may deepen our understanding and add imaging signs about giant cell tumor of bone;Which can enhance our diagnostic and differential diagnostic capability.

Nanomaterials, with the advantages of unique microstructure, have been widely used in the fields of material manufacturing, microelectronics and computer technology, medicine and health, environment and energy. Compared with traditional hemostatic materials, nanomaterials can improve the bioavailability and stability of traditional hemostatic drugs to a certain extent, enhance the controlled and targeted release of drugs, which lay a good foundation for the development of new-style modern hemostatic nanomaterials. This paper reviews the advanced design and application progress of various nanomaterials in hemostasis, such as liposomes, nanoparticles, self-assembled nano peptides, nanofibers, etc. Finally, the challenges and prospects of hemostatic nanomaterials are briefly described.

Objective To investigate the prognosis of middle-aged and elderly patients with aspiration pneumonia and related influencing factors in integrated medical and elderly care institutions. Methods A total of 604 elderly patients with aspiration pneumonia were selected from integrated medical and elderly care institutions from January 2016 to December 2020. The prognosis of the patients was counted, and the prognostic factors were analyzed by univariate and multivariate logistic regression equations. The receiver operating characteristic (ROC) curve and area under the curve (AUC) were used to analyze the predictive value of logistic regression model for the prognosis of elderly patients with aspiration pneumonia. Results Univariate analysis showed that Alzheimer's disease, severe pneumonia, ability of daily living (ADL), and the number of rescues were related to the prognosis of elderly patients with aspiration pneumonia (P<0.05). Logistic regression model showed that the death risk of patients with Alzheimer's disease was 2.883 times higher than that of patients without Alzheimer's disease, the death risk of patients with severe pneumonia was 3.292 times higher than that of patients without severe pneumonia, the death risk of patients with severe dependence in ADL was 3.719 times higher than that of patients with mild dependence, the death risk of patients with moderate dependence in ADL was 2.558 times higher than that of patients with mild dependence, and the death risk of patients with rescue times ≥ 2 times was 2,922 times higher than that of patients without rescue times (P < 0.05). Logistic regression equation: logistic (P=-8.264+2.883)×Alzheimer disease ≥60 years old + 3.292×severe pneumonia + 3.719×severe dependence in ADL+2.558×moderate dependence in ADL +2.922× number of rescues. The predicted prognosis AUC of elderly aspiration pneumonia was 0.907 (95%CI: 0.848-0.966). When logistic(P>12.97), the predictive value was the best, with the predictive sensitivity being 83.87%, and the specificity being 84.15%. Conclusion Alzheimer's disease, severe pneumonia, moderate and severe dependence in the ability of daily living and rescue times ≥ 2 are related to the prognosis of middle-aged and elderly patients with aspiration pneumonia in the integrated medical and elderly care institutions, which can be used as a prognostic plan for clinical treatment and nursing management. At the same time strengthening the intervention of patients with the above characteristics will help to promote the improvement of prognosis.