Objective To investigate the clinical value of chemokine ligand 20(CCL20)-chemokine recep-tor 6(CCR6)axis combined with carbohydrate antigen 125(CA125)in predicting the outcome of acute myo-cardial infarction(AMI).Methods A total of 98 patients with AMI from January 2022 to January 2023 were selected as the study group and 49 healthy subjects were selected as the control group.The serum levels of CCL20,CCR6 and CA125 in the two groups were compared,and the serum levels of CCL20,CCR6 and CA125 in patients with different severity of coronary lesions in the study group were compared at admission,and the correlation between the serum levels of CCL20,CCR6 and CA125 in the study group and the severity of coro-nary lesions was analyzed.All the study groups were treated with percutaneous coronary intervention,and were divided into good prognosis group and poor prognosis group according to whether major cardiovascular adverse events occurred within 6 months after treatment.The clinical data and serum levels of CCL20,CCR6 and CA125 at admission were compared between the two groups,and the influencing factors of poor prognosis were analyzed,and the value of serum levels of CCL20,CCR6 and CA125 at admission in predicting poor prog-nosis was analyzed.Results The levels of CCL20,CCR6 and CA125 in the study group were higher than those in the control group(P＜0.05).The serum levels of CCL20,CCR6 and CA125 in patients with severe coro-nary lesions were higher than those in moderate and mild patients,and those in moderate patients were higher than those in mild patients(P＜0.05).The serum levels of CCL20,CCR6 and CA125 were positively correla-ted with the severity of coronary lesions(P＜0.05).Age,severity of coronary lesions,history of myocardial infarction,serum levels of CCL20,CCR6 and CA125 in the poor prognosis group were higher than those in the good prognosis group(P＜0.05).Age,previous history of myocardial infarction,serum levels of CCL20,CCR6 and CA125 were all influential factors for poor prognosis of AMI patients after PCI(P＜0.05).The ar-ea under the curve(AUC)of serum CCL20,CCR6 and CA125 in predicting poor prognosis after PCI was 0.762,0.819 and 0.778,respectively,and the AUC predicted by the combination of all indicators was 0.936,which was greater than that predicted by all indicators alone(P＜0.05).Conclusion The combination of ser-um CCL20,CCR6 and CA125 levels on admission has high predictive efficacy in predicting the poor prognosis of AMI patients after PCI,and can provide a reliable basis for clinical prediction of the disease outcome direc-tion of patients.