Human papillomavirus (HPV) is a major causative agent of cervical cancers. Over the past several decades, increasing number of studies established strong association of HPV with a subset of head and neck squamous cell carcinomas (HNSCCs). In the present study, we reviewed evidence, including epidemiology, carcinogens, diagnosis, treatment, and prognosis, showing that HPV-positive HNSCCs exhibit a variety of distinct characteristics for understanding tumor biology and improving cancer treatment.
Carcinoma, Squamous Cell ; virology ; Head and Neck Neoplasms ; virology ; Humans ; Papillomaviridae ; Papillomavirus Infections ; Prognosis

OBJECTIVE: To introduce a new method of complete remaining parotid fascia in parotidectomy, preventing Frey's syndrome. METHOD: Thirty-five patients with benign tumor in the parotid gland were treated by remaining parotid fascia. All 35 patients were followed up after 6 months to 24 months. RESULT: The parotid fasciae of 26 out of 35 were remained completely and none of these 26 patients developed Frey's syndrome. The parotid fasciae of 9 out of 35 were excised partly and Frey's syndrome occurred in 2 of these 9 patients. There was significant difference of Frey's syndrome between the parotid fasciae being remained completely and the parotid fasciae being remained partly. CONCLUSION The parotid fascia could be reserved completely in parotidectomy. The complete parotid fascia could prevent Frey's syndrome in the patients after undergoing parotidectomy.
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Child ; Fasciotomy ; Female ; Humans ; Male ; Middle Aged ; Parotid Gland ; surgery ; Parotid Neoplasms ; surgery ; Postoperative Complications ; prevention & control ; Sweating, Gustatory ; prevention & control ; Young Adult