Objective To investigate the application effects of modified laparoscopic totally extraperitoneal prostheic in the treatment of inguinal hernia.Methods 100 patients with inguinal hernia were selected,and they were divided into control group (50 cases) and observation group (50 cases) according to the digital table.The control group was treated with opening totally extraperitonea prosthetic,the observation group was treated with modified laparoscopic totally extraperitoneal prostheic.The operation time,hospital stay,leaving bed time,visual analogue scale (VAS score),adverse reaction and recurrence between the two groups were compared.Results The operation time between the two groups had no significant difference (P ＜ 0.05).The leaving bed time,hospital stay and VAS score of the observation group were (13.54 ± 3.81) h,(5.04 ± 1.24) d,(3.46 ± 0.75) points,repectively,which of the control group were (25.76 ± 4.35) h,(8.39 ± 1.65) d,(7.19 ± 1.27) points,repectively,the differences were statistically significant(t =14.943,11.477,17.882,all P ＜ 0.05).There was no statistically significant difference in the incidence of scrotal effusion,hematoma and wound infection between the two groups (all P ＞ 0.05).The incidence rates of chronic pain(2.00％ vs.16.00％) and adverse reactions(10.00％ vs.30.00％) in the observation group were lower than those in the control group,the differences were statistically significant (x2 =5.983,6.250,all P ＜ 0.05).After 6 months' follow-up,2 cases(4.00％) occurred recurrence in the observation gToup,3 cases(6.00％) occurred recurrence in the control group,the recurrence rate between the two groups had no statistically significant difference (x2 =0.211,P ＞ 0.05).Conclusion Modified laparoscopic totally extraperitoneal prostheic can effectively relieve the postoperative pain degree and improve the adverse reaction rate,and with fast recovery.