Objective To explore the characteristics of deficit in action imitation upon objects for the children with autistic spectrum disorder(ASD). Methods Imitative tasks involved objects under the condition of different time after the modelling action ,different action number, different action meaning were used to examine the variations between 12 young children with ASD,and with deaf children(D) matched with the non-verbal IQ and CA( n= 12) ,and children with mental retardation (MR) matched with verbal IQ and CA( n= 12). Results Analyses of repeated ANOVA revealed that: there were significant main effect on the imitation of action involved objects within three subjects(F(2.33) = 10. 138, P＜0.01 ) ;the individuals with ASD achieved lower scores(0.766 ±0.029 ) than the children with MR (0.861 ± 0. 029 ), and the children with deaf significantly ( 0. 949 ± 0. 029). Especially,the autistic imitation deficit was shown on tasks of deferred and meaningless action imitation. Conclusion Children with ASD show deficit on imitation involved objects significantly.

Objective To investigate and analyze the diagnosis and treatment of gerontal large intestinal carcinoma patients complicating with intestinal obstruction.Methods The perioperative medical care and treatments of 94 cases of gerontal large intestinal carcinoma patients admit in our hospital were retrospectively analyzed.Results 85 cases (90.4%) of patients fully recovered and 9 cases(9.4%)died.Conclusions Thinking highly of the perioperitive medical care of gerontal large intestinal carcinoma complicating with intestinal obstruction and handling the postoperative complications effectively are the key point to lower the mortality and elevate the achievement ratio.

MIC.RESULTS The bacteriostatic/bactericidal CFR of 0.5g q8h imipenem/cilastatin and 0.5g q8h meropenem were the highest(100%);that of 3.375g q4h sodium piperacillin/tazobactam sodium against ESBLs-producing E.coli was above 90%;the CFRs of ceftriaxone(1g q24h,2g q24h),ceftazidime(1g q8h,2g q8h),cefepime(1g q8h,1g q12h,2g q8h) and cefoperazone sodium/sulbactam(0.5g q8h,1g q8h,2g q8h) against ESBLs-producing strains were clearly less than those of non-ESBLs-producing ones,and the CFRs could not be effectively improved with the dose and frequency increased.CONCLUSIONS The PK/PD simulation is useful to optimize the regimen of anti-infective treatment,and guide its dosing accurately.

Objective To explore the diagnosis,treatment and prognosis of primary gastric malignant (lymphoma)(PGML).Methods The diagnosis and treatment data of 21 cases of PGML admitted in our(hospital) during 8 years was retrospectively analyzed.The diagnostic methods included barium meal(examination),gastroscopy,B type ultrasonography,and CT scan.All patients underwent operative treatment and most of the patients received adjuvant chemotherapy.Results Upper abdominal pain,digestive tract bleeding,emaciation and abdominal mass were common clinical manifestations of PGML.The resectabilty rate of PGML was 90.5% while the 5-year survival rate was 57.1%.Conclusions The key to a satisfactory prognosis was early diagnosis,radical curative operation and combined treatment.

Objective To investigate the correlation between midkine(MK) and VEGF expression with angiogenesis and biological features in recurrent gastric carcinoma.Methods The expression of MK was examined using immunohistochemistry in 9 cases of gastric carcinoma and 9 cases of adjacent normal tissues.Microvessel density(MVD)was determined by VEGF immunohistochemical staining.Results Majority of recurrent gastric carcinoma tissues showed positive reaction to immunostaining,but no specific positivity was detected in adjacent normal tissue.Values of MVD and MK positive group(88.8%,79.75) was higher than those in the negative group(15.0%)(P

Objective To explore the effect and application of the clinical teaching method of stage-separated to targeted management in the comprehensive ICU. Methods ICU rotation learning plans were developed for 113 probationers and rotating physicians,who were given the training of stage-separated to targeted teaching. The program was divided into three stages based on corresponding teaching objective and comprehensive examination and assessment with combination the dynamic and static evaluation were carried out to three parts. Results The probationers and rotating physicians had significant improvement in the familiarity and mastery of ICU specialist knowledge and skills through the systematic training. Conclusion Such training program can effectively improve the ICU specialized quality and comprehensive ability of the probationers and rotating physicians and bring about better clinical teaching effect.

Objective To investigate the expression alteration and significance of long non-coding RNA (lncRNA)by GWAS(Genome-wide association study)between Esophageal squamous cell carcinoma(ESCC)and its adjacent normal esophageal tissues. Methods lncRNA and mRNA differential expression in 6 pairs of ESCC and matched non-cancerous tissues were screened by microarray assay. The target genes were predicted. Finally , GO(Gene Ontology)and Pathway analysis was used for the further research of lncRNA. Results A total of 680 lncRNA and 1472mRNA were differentially expressed at more than two-fold change(P ≤ 0.05,with 161lncRNA and 653mRNA up-regulated,519lncRNA and 819mRNA down-regulated between ESCC and its adjacent normal esophageal tissues. Gene ontology and pathway analysis results suggested that the differentially expressed genes were involved in 11 pathways.Theyare potentially associated with esophageal squamous cell carcinoma ,including post-translational protein modification ,mucin type O-Glycan biosynthesis and sphingolipid metabolism pathways , which mainly related to the changes of molecular function ,cellular components and biological processes. Through cis and trans analysis,a total of 15 differentially expressed lncRNA had cis-and/or trans-regulated target genes in the database,with 13 lncRNA had cis-regulated target genes,3 lncRNA had trans-regulated target genes,and 1 lncRNA had both cis- and trans-regulated target genes. Conclusion Compared with adjacent normal tissues ,a large number of lncRNA were expressed differentially in ESCC in Xinjiang Han people.Aberrantly expressed lncRNA may play important roles in ESCC development and progression through some signaling pathways ,which are of great significance for further search of new targets for the diagnosis and treatment of ESCC.

Objective To investigate microstructure of the corpus callosum(CC) in subacute diffuse axonal injury(DAI) patients and its the longitudinal change in a short time.Methods 21 patients with subacute DAI were enrolled successively in this study,and in which 12 patients were reexamined followed-up with DTI a month later (31.5 d±6.2 d,28-43 d),and then 12 gender and age matched healthy controls were recruited.The DTI data of all subjects were acquired on at a 3.0T MRI.The CC was divided into six segments:the genu, rostral mid-body, anterior mid-body,posterior mid-body, isthmus, and splenium.ROIs were placed on each segment on color fractional anisotropy (FA) maps in the midsagittal plane manually.The FA and apparent diffusion coefficient(ADC) values of each subregion of CC were measured and compared between subacute DAI group,follow-up group and controls respectively.In addition,a related analysis between DTI parameters of each sub-region of CC and GCS on admission was done by using person correlation analysis.

Objective To explore the application value of SWI in hyperacute ischemic cerebral infarction.Methods 40 patients with massive hyperacute ischemic cerebral infarction in middle cerebral artery (MCA)territory were enrolled successively who underwent MR imaging with conventional MRI,DWI,MRA and SWI sequence immediately.The MR images were analyzed by two senior neuroimaging physicians and the results were recorded.The number of thrombosis at MCA showed on SWI was compared with that showed on conventional MR sequence and the number of MCA stenosis or occlusion showed on MRA,the length of thrombosis and the number of cases with veins increased in infarct area were also compared.Results The number of thrombosis at MCA showed on SWI was more than that showed on conventional MR sequences significantly (23 vs 12,χ2 =6.146,P =0.013),and was lower than that showed on MRA (23 vs 24,χ2 =0.052, P =0.820)slightly.Thrombosis at MCA trunk and its small branches were found in the meantime in 2 cases .The length of thrombosisshowed on SWI was longer than that showed on conventional MRI sequences (25.7 mm±9.4 mm vs 14.6 mm±8.5 mm,t=14.395,P =0.000), significantly and the number of patient with veins increased in infarct area showed on SWI was more than that showed on conventional MR sequences (21 vs 12,χ2 =4.1 78,P =0.041)significantly.Conclusion SWI has usefull application value in patients with hyperacute massive ischemic cerebral infarction.