1.Undergraduate thesis project in major of biomedical engineering
Da JING ; Erping LUO ; Guanghao SHEN ; Xiaoming WU ; Chi TANG ; Kangning XIE ; Wei GUO
Chinese Medical Equipment Journal 2015;(9):141-143
The factors for the undergraduate thesis design in biomedical engineering specialty were analyzed from the as-pects of tutor, student and administration, and some suggestions were proposed accordingly to enhance the undergraduate thesis design in biomedical engineering specialty.
2.The Three-dimensional Finite-Element Simulation of Alternating Electromagnetic Fields for Microcirculation Experiments
Yili YAN ; Guanghao SHEN ; Chi TANG ; Kangning XIE ; Xiaoming WU ; Erping LUO
Chinese Journal of Medical Physics 2009;26(6):1540-1542,1553
Objective: In order to understand temporal and spatial distributions of alternating electromagnetic field (AEMF) of a coil thoroughly, the 3-D finite-element models of this kind of Biomagnetic Fields are established and analyzed for the research on bioeffect of magnetic field on microcirculation. Methods: Designing CAD models, setting boundary conditions, meshing models and obtaining numerical solutions were completed all within Comsol Multiphysics in terms of the theory of electromagnetic field. Results: Axial and radial plot of spatial attenuation rate of the AEMF, which were accordance with measured data, were simulated while the temporal and spatial distributions of AEMF were acquired. Conclusion: Models of 3-D finite-element of this kind of biomagnetic fields which appeared to exactly simulate the real magnetic field were first established systematically, and solved the placing problem of magnetic fields for the research on bioeffect of magnetic field on microcirculation and provided platforms for the simulation of hemodynamic of blood flow in the magnetic field.
3.Investigating the teaching methodology of English for science and technology in the major of biomedical engineering
Da JING ; Erping LUO ; Kangning XIE ; Guanghao SHEN ; Chi TANG ; Xiaoming WU ; Wei GUO ; Juan LIU ; Shichao TONG
Chinese Journal of Medical Education Research 2015;(1):91-93
English for science and technology (EST) is the language medium for academic communication among scientists and technologists. The expression of EST is characterized by concise-ness, correctness, objectiveness and understandability. The EST course is regarded as a key process for the undergraduate students to reinforce the English foundation and improve the capacity of English application after their College English study. In this paper, the authors introduced an interest-motivated, output-dominated, snowballing and interactive teaching strategy, according to the accumulated experi-ence of EST teaching in the past few years coupled with the unique medicine-engineering combined characteristics for the major of biomedical engineering.
4.Effects of Mechanical Stimulation on Polarity of Macrophages
Guanghao CHI ; Banruo LI ; Wei WU ; Min HAO ; Jian MA ; Longshun QIU
Journal of Medical Biomechanics 2020;35(6):E739-E743
Objective To explore the effect of mechanical stimulation on polarity of macrophages. Methods RAW264.7 cells were stimulated with tensile stretch at various amplitude and time, then cell viability was assessed with cell count kit-8 (CCK-8) for determining the stimulation parameters. RAW264.7 cells were induced to M1 type, then tensile stretch at 10% amplitude and 2 Hz was applied to M1 cells. CCK-8 and flow cytometry were used to detect the effects of tensile stretch on cell activity and apoptosis. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect the effect of tensile stretch on M1 type macrophage related gene expression. Results After stimulation for 3 hours, tensile stretch at 15% or 20% amplitude and 2 Hz significantly inhibited cell viability (P<0.05), while tensile stretch at 10% amplitude and 2 Hz did not inhibit the viability of RAW264.7 cells (P>0.05). Tensile stretch at 10% amplitude and 2 Hz neither inhibited viability nor cause apoptosis of M1 type macrophages. The expression of inflammation-related genes including interleukin-1β(IL-1β) and tumor necrosis factor-α (TNF-α) of M1 type macrophages was significantly down-regulated with tensile stretch at 10% amplitude and 2 Hz (P<0.05). Conclusions Mechanical stimulation at 10% amplitude and 2 Hz can inhibit M1 type macrophages and promote the polarization from M1 to M2. Mechanical stimulation may become a method for treating inflammation-related diseases.