1.Study on the relationship between leptin and neonatal weight and the expression of leptin in placenta
Tong LIU ; Tao SHANG ; Guanghai RUI
Chinese Journal of Obstetrics and Gynecology 2001;0(05):-
Objective To investigate the relationship between the leptin level and neonatal weight and the expression of leptin in placenta. Methods The concentrations of leptin in 100 maternal blood and umbilical blood of the term pregnant women were examined by radioimmunoassay (RIA). According to the neonatal weight to divide into the large for gestational age (LGA) group 19 cases, the appropriate for gestational age (AGA) group 65 cases, the small for gestational age (SGA) 16 cases. The level of leptin mRNA in 41 placental tissue was examined by Reverse transcription polymerase chain reaction (RT PCR). Results (1) The expression level of leptin mRNA in placenta was 0 97?0 04, which was positively related to the neonatal weight significantly ( r =0 43, P 0 05).(3)The concentration of leptin in umbilical blood was (7 58? 5 15) ?g/L, which was positively related to the neonatal weight ( r =0 57, P
2.Application of lipidomics in colorectal cancer
Guanghai TONG ; Yang TIAN ; Huaxing WU
Practical Oncology Journal 2019;33(2):179-182
Colorectal cancer is one of the most common malignant tumors in China. It poses a serious threat to health and its morbidity and mortality are increasing year by year. There are defects in early diagnostic markers and disease activity progression indi-cators for clinical applications. Lipidomics helps to analyze the etiology,pathological progression and clinical diagnosis of colorectal cancer by comparing differences in lipid metabolites in vivo,providing a new method and platform for research of colorectal cancer. This review is aimed at the application of lipidomics in colorectal cancer.
3. Investigation of dose-dependent association between bedtime routines and sleep outcomes in infants and toddlers
Fang YANG ; Qingmin LIN ; Guanghai WANG ; Yanrui JIANG ; Yuanjin SONG ; Shumei DONG ; Wanqi SUN ; Yujiao DENG ; Yan WANG ; Xiaojuan XU ; Qi ZHU ; Fan JIANG
Chinese Journal of Pediatrics 2017;55(6):439-444
Objective:
To investigate the current bedtime routine among Chinese children less than 3 years of age and explore its dose-dependent association with sleep duration and sleep quality.
Method:
Healthy full-term born children aged 0-35 months were selected by stratified cluster random sampling method from 8 provinces in China following the "Hospital of Province-City-County" sampling technical route during 2012-2013.Brief Infant Sleep Questionnaire(BISQ) was used to assess sleep conditions of these children.Children′s personal and family information was obtained by Shanghai Children′s Medical Center Socio-demographic Questionnaire.Both of these questionnaires were filled in by parents. The effects of bedtime routine on children′s sleep duration and quality were analyzed by multivariate analysis of variance.
Result:
The children′s average age was(12±10) months(
4.Emotional and behavioral effects of after-school tutoring on school-age children in a district in Shanghai
Xiaoyan QIU ; Jinjin CHEN ; Guanghai WANG ; Yu WANG ; Yuanyuan ZHANG ; Yanyan QIU ; Azhu DUAN ; Guangjun YU
Shanghai Journal of Preventive Medicine 2023;35(8):791-798
ObjectiveTo explore the effects of after-school tutoring for school-age children on their emotions and behaviors, and to provide a basis for developing after-school tutoring and psychological support strategies for school-age children. MethodsFour elementary schools in a district of Shanghai were selected by simple random sampling method. Whole group sampling was conducted by class, and parents of students were surveyed by general questionnaire and the scale of strengths and difficulties. Information was collected on the basic conditions of children and families and the results were compared and analyzed. ResultsThis study showed that 88.26% of children attended extracurricular classes, of which 26.16% attended 3 or more classes, 42.5% attended cultural classes, 28.3% attended sports classes, and 59.8% attended art classes. Children who did not attend classes had higher pro-social scores. Children who attended reading class had lower scores for emotional problems that was a protective factor for emotional problems. Children who chose extracurricular programs in sports and reading also had lower overall scores for difficulties. Excessive use of electronic devices by school-age children on weekdays or weekends had a negative effect on emotional and conduct problem scores regardless of whether they chose extracurricular programs. It appeared that the choice of cultural programs, art programs and different levels of exercise intensity had no effect on children's emotions and behaviors. ConclusionFor children with low pro-social level, extracurricular classes should be carefully selected. For extracurricular classes, more reading and sports-related courses can be considered, which have positive effects on school-age children’s emotions and behaviors. Regardless of the choice of extracurricular classes, try to avoid excessive online classes.
5.Surgical treatment of latent infection of 2019 novel coronavirus (SARS-CoV-2) with esophageal foreign body perforation: A case report
TONG Song ; CHEN Zhuo ; WU Chuangyan ; XU Kaiying ; YANG Guanghai ; LIAO Yongde ; WANG Sihua
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery 2020;27(03):240-242
This study reports the surgical treatment of a female patient at age of 64 years with novel coronavirus (SARS-CoV-2) latent infection complicated with esophageal foreign body perforation with no significant changes in the lung CT. The patient was confirmed as SARS-CoV-2 infection on the 4th day after surgery and then was transferred into the Department of Infectious Disease in our hospital for treatment. This case has guiding value for the operation of thoracic surgery during the outbreak of novel coronavirus pneumonia.