1.Progress in research of liver sinusoidal endothelial cells and liver regeneration
Guangchen ZU ; Yuwei TAN ; Xuemin CHEN ; Yue ZHANG
Chinese Journal of Hepatobiliary Surgery 2019;25(7):546-549
Liver can be regenerated after chemical injury or localized resection of the surgery by dynamic interactions between hepatocytes and non-parenchymal cells. Liver sinusoidal endothelial cells (LSECs) are the most abundant cells in liver non-parenchymal cells and participate in liver development, injury and regeneration. Currently more and more studies have shown that LSECs are essential for hepatocyte regeneration. In this paper, we summarized the research progress of LSECs and liver regeneration in recent years, aiming to provide new ideas for promoting liver regeneration by targeting LSECs.
2. The learning curve of laparoscopic pancreaticoduodenectomy based on the initial 112 patients
Yuwei TAN ; Tianyu TANG ; Yue ZHANG ; Liwei ZHANG ; Guangchen ZU ; Yong AN ; Weibo CHEN ; Di WU ; Donglin SUN ; Xuemin CHEN
Chinese Journal of Hepatobiliary Surgery 2019;25(10):763-767
Objective:
To study the learning curve of laparoscopic pacreaticoduodenectomy (LPD) with a view to find an appropriate way to develop LPD step by step.
Methods:
112 consecutive patients who completely underwent LPD in a single surgery center at the First People’s Hospital of Changzhou from December 2015 to February 2018 were retrospectively reviewed. By using both the cumulative sum (CUSUM) and the risk-adjusted CUSUM (RA-CUSUM) methods to analyze the perioperative data of these patients, the learning curve of LPD was studied in a more scientific way.
Results:
The learning curve could be divided into three phases: Phase 1, the initial period (the initial 45 patients); Phase 2, the enhancement period (the subsequent 31 patients); Phase 3, the maturation period (the remaining patients). For these 3 phases, the corresponding operative times were (448.4±75.0), (381.3±74.3), and (336.2±52.1) min, respectively (