2.Study of standardization of syndrome diagnosis: an analysis of current status
Huafeng WEI ; Guang JI ; Peiyong ZHENG
Journal of Integrative Medicine 2007;5(2):115-21
It is one of the key problems for the development of Chinese medicine to standardize the diagnosis of syndromes. The authors mainly discuss the ideas and methods of the study of standardization of syndrome diagnosis by retrospective analysis, also put forward the following suggestions: (1) the main ideas of this study should be based on the comparison of the diseases and their relevant syndromes and the predictive diagnosis of syndromes by the effects of herbal prescription treatment; (2) they are important ways to carry out multicenter, large sample and perspective clinical trials on the basis of the investigation and study of literature, consultation of experts and retrospective case review, and following the principles of clinical epidemiology, and to use the methods of evidence-based medicine to do systemic evaluation on the criteria of syndrome diagnosis; (3) they are important sectors of the study of standardization of syndrome diagnosis to enhance the objective studies on the four diagnostic methods of traditional Chinese medicine, and to do the functional studies under the conduction of systems biology; (4) Both data excavation technology and computer intelligence are the important technique supporting this study.
3.General methods for clinical effect assessment of traditional Chinese medicine
Huafeng WEI ; Peiyong ZHENG ; Guang JI
Journal of Integrative Medicine 2005;3(3):184-90
Along with the changes of disease spectrum, medical models and health concept, people pay more and more attention to the diagnostic and therapeutic approaches of traditional Chinese medicine (TCM). With the effect assessment being changed from disease-based model to patient-based model, how to scientifically and objectively explain the validity of TCM has become the premise for further development of TCM and dissemination of it throughout the world. In this article, the authors analyzed the status quo and problems of the effect assessment of TCM, and proposed some general methods for clinical effect assessment of TCM, including formulating criteria for syndrome differentiation under the guidance of TCM theories, paying attention to quality of life, proper selection of indexes for outcome assessment, application of modern clinical study methods, such as the methods of evidence-based medicine and clinical epidemiology, designing randomized controlled trials, multi-subject co-operation, strict supervision of the quality of researches, and establishment of organizations for professional training.
5.Neonatal lacunar skull in two cases.
Yi-jun WEI ; Guang CHENG ; Ji-chang CHEN
Chinese Journal of Pediatrics 2010;48(4):308-309
6.Distribution pattern of traditional Chinese medicine syndromes in 793 patients with fatty liver disease.
Huafeng WEI ; Tao LIU ; Lianjun XING ; Peiyong ZHENG ; Guang JI
Journal of Integrative Medicine 2009;7(5):411-7
To study the distribution pattern of traditional Chinese medicine (TCM) syndromes in fatty liver disease.
9.Epithelioid angiosarcoma after radical mastectomy for breast carcinoma: a case report.
Hong-ji DING ; Guo-guang WEI ; Li-qun YU ; Qi-song WU ; Yan-guang DONG
Chinese Journal of Pathology 2006;35(10):637-638
Aged
;
Antigens, CD34
;
metabolism
;
Breast Neoplasms
;
metabolism
;
pathology
;
therapy
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Chemotherapy, Adjuvant
;
Combined Modality Therapy
;
Epithelioid Cells
;
pathology
;
Female
;
Follow-Up Studies
;
Hemangiosarcoma
;
metabolism
;
pathology
;
Humans
;
Immunohistochemistry
;
Mastectomy, Radical
;
Neoplasms, Second Primary
;
metabolism
;
pathology
;
Radiotherapy, Adjuvant
;
Vimentin
;
metabolism
10.Discovery of topiramate's new functions based on medicinal property combinations and study on its mechanism.
Guang-Ji LI ; Hao GU ; Wei-Jia GUO ; Yan-Ling ZHANG ; Yun WANG ; Yan-Jiang QIAO
China Journal of Chinese Materia Medica 2014;39(13):2396-2399
OBJECTIVETo study topiramate's new functions according to the medicinal property combinations, in order to apply the traditional Chinese medicinal theory in discovering new purposes of old drugs.
METHODAccording to New Traditional Chinese Medicinal Families--Chemical Traditional Chinese Medicines, the authors found out topiramate's property. Then based on the therapeutic principle of diabetes, hypertension, epilepsy and lung cancer, as well as the relations of efficacies and medicinal property combinations, they summarized the corresponding medicinal property combination modes, compared topiramate's medicinal property combination mode with corresponding medicinal property combination modes of these diseases, and predict topiramate's new functions.
RESULTAccording to the comparison, the corresponding medicinal property combinations were consistent with topiramate's medicinal property combinations as evidenced by corresponding literatures, whereas other medicinal property combinations were not.
CONCLUSIONBased on medicinal property combination modes, the authors screened topiramate's new functions according to e of TCM clinical experience, discovered topiramate's therapeutic effects on diabetes, hypertension and lung cancer in addition to epilepsy, and explore new drug function according to medicinal property combination modes, which could help greatly shorten the new drug R&D period.
Diabetes Mellitus ; drug therapy ; Drug Therapy, Combination ; Drugs, Chinese Herbal ; chemistry ; therapeutic use ; Fructose ; analogs & derivatives ; chemistry ; therapeutic use ; Humans ; Hypertension ; drug therapy ; Lung Neoplasms ; drug therapy ; Phytotherapy