1.Effects of constant low temperature on cold resistance of different strains Polygonatum odoratum.
Er-Huan WANG ; Yong-Hua XU ; Zhong-Bao ZHAND ; Dian-Wen XU ; Guang-Sheng XI ; Lian-Xue ZHANG
China Journal of Chinese Materia Medica 2015;40(1):68-72
In this paper, the five strains of Polygonatum odoratum were used as the experimental materials to test the supercooling point, freezing point, the degree of supercooling, the transition stage time, cooling time and water composition of the plant tissue. The cold resistance of P. odoratum was analyzed with the Gray Correlation Method. The results showed that the cold resistances of the five strains of P. odoratum were different, and the water content of plant tissue had some relevance with freezing point and supercooling point, whereas, it could not be measured when the moisture content was too low. The order of cold resistance of the five strains of P. odoratum was ZJCY, DYYZ, XYYZ, CYYZ and JZ I.
Cold Temperature
;
Plant Roots
;
chemistry
;
physiology
;
Polygonatum
;
chemistry
;
classification
;
physiology
;
Water
;
analysis
2.Comparative study of myocardial perfusion imaging and 64 multi-slice spiral CT for the diagnosis of coronary artery disease
Jun, ZHAO ; Long-bao, XU ; Ren-ming, WAN ; Guang-lei, FAN ; Jian-wen, LIU ; Shu-xing, HUANG
Chinese Journal of Nuclear Medicine 2010;30(6):367-371
Objective To compare the diagnostic value of myocardial perfusion imaging (MPI) and 64 multi-slice spiral CT (64-MSCT) for coronary artery disease (CAD). Methods Fifty-two patients with suspected or known CAD were included in the study. Each patient underwent both stress and rest MPI,MSCT as well as conventional coronary angiography (CAG) within 1 month. The stress and rest MPI were scored by a 5-grade criteria (0 ~ 4) based on 17 coronary artery segments. The difference between summed stress and rest scores > 1 was defined as myocardial ischemia. Stenosis in one main vessel or one main branch of the main vessel ≥50% was defined as myocardial ischemia by MSCT. CAG was used as the reference for comparison. Statistical analysis was performed using SPSS 13. 0 software. Kappa value was used to test the accordance of MPI and MSCT results. X2 test was used to evaluate the difference between MPI and MSCT results. Results The patient-based sensitivity, specificity, positive and negative predictive values and accuracy of MPI and MSCT for the diagnosis of CAD were 86.7% (26/30), 77.3% ( 17/22),83.9% (26/31), 81.0% ( 17/21), 82.7% (43/52) and 83.3% ( 25/30), 86.4% ( 19/22), 89.3%( 25/28), 79.2% ( 19/24), 84.6% (44/52), respectively. The vessel-based sensitivity, specificity, positive and negative predictive values and accuracy of MPI and MSCT were 74.5% (38/51), 81.0% (85/105 ), 65.5% (38/58), 86.7% ( 85/98), 78.8% ( 123/156 ) and 90.2% (46/51 ), 88.6% ( 93/105 ),79.3 % (46/58), 94.9% (93/98), 89.1% ( 139/156), respectively. There was no statistically significant difference between MPI and MSCT for either patient or lesion-based diagnosis (X2 =0.44, 0.21, both P >0.05 ). 96.0% (24/25) patients with both abnormal MPI and MSCT positive were valified by CAG while 83.3% (15/18) patients with both MPI and MSCT negative were excluded by CAG. Conclusions Both MPI and MSCT are reliable diagnostic modalities for CAD. They also provide complementary diagnostic value to each other.
3.Low-grade (fibromatosis-like) spindle cell carcinoma of the breast: case report and review of the literature.
Feng TANG ; Dong-hua GU ; Yun BAO ; Hong WANG ; Hong-guang ZHU ; Zu-de XU ; Xi-qi HU
Chinese Journal of Pathology 2005;34(7):444-445
Breast Neoplasms
;
metabolism
;
pathology
;
surgery
;
Carcinoma
;
metabolism
;
pathology
;
surgery
;
Diagnosis, Differential
;
Female
;
Fibroma
;
metabolism
;
pathology
;
surgery
;
Humans
;
Keratins
;
metabolism
;
Middle Aged
;
Vimentin
;
metabolism
4.Progress in the studies on small molecule IGF-1R inhibitors.
Yan XU ; Guang-shu WANG ; Wei SUN ; Xiao-hong YANG ; Li-bao XU
Acta Pharmaceutica Sinica 2008;43(10):979-984
The importance of insulin-like growth factor 1 receptor (IGF-1R) signaling in malignant behaviour of tumour cells is well established. Inhibiting the activity of IGF-1R may result in striking apoptosis in malignant cells growing. IGF-1R antibodies which are currently in phase I and II clinical trials and several IGF-IR TKIs have preclinically been characterized. This review describes recent developments of small molecule tyrosine kinase inhibitors.
Animals
;
Apoptosis
;
drug effects
;
Benzimidazoles
;
pharmacology
;
Catechin
;
analogs & derivatives
;
pharmacology
;
Cell Line, Tumor
;
Humans
;
Neoplasms
;
pathology
;
Piperazines
;
pharmacology
;
Protein Kinase Inhibitors
;
pharmacology
;
Pyridones
;
pharmacology
;
Pyrimidines
;
pharmacology
;
Pyrroles
;
pharmacology
;
Receptor, IGF Type 1
;
antagonists & inhibitors
;
chemistry
;
metabolism
;
Signal Transduction
5.Clinical application of maxillary sinus lift with Summers osteotome.
Lei ZHOU ; Shu-lan XU ; Shi-tong XU ; Jian-sheng HUANG ; Guang-bao SONG ; Xue-yang ZHANG
West China Journal of Stomatology 2008;26(3):296-298
OBJECTIVETo introduce and evaluate the procedure and the effect of maxillary sinus lift with closed technique by Summers osteotome, bone grafting and simultaneous implant placement.
METHODS66 cases with severely resorbed alveolar bone in maxillary posterior region received sinus lift with Summers osteotome, simultaneously bone grafting and implants placement. The final restoration was finished at 6 months postoperatively.
RESULTSThe operation procedure were eventless in the 66 cases, the sinus floor were elevated by 2-5 mm, three-dimensional reconstruction of the CT scan pictures showed the smooth dome profile of the lifting sites and no signs of laceration on the membrane, and there were no maxillary antritis after operation. After 6 months, no significantly bone graft resorption and good osseointegration were noticed in X-ray imaging. The final restoration was finished at this time. 12-24 months after the restoration, all implants inserted were remain, the hard and soft tissue were healthy, prosthesis were stable and functioned. X-ray showed good osseointegration in the lifting sites, the vertical resorption around the implants were less than 1 mm.
CONCLUSIONWith properly use of Summers osteotome, scraps of the bone in the implant sockets can be pushed into the sinus, these autogenous bone scraps were in favor of the osseogenesis and the sinus floor can be easily elevated by the method with very infrequent complications. It enlarged indication of dental implants and avoided operation of harvesting autogenous bone in other site. The method is simple and valuable to clinical application.
Adult ; Alveolar Bone Loss ; Bone Transplantation ; Dental Implantation, Endosseous ; Dental Implants ; Humans ; Male ; Maxilla ; Maxillary Sinus ; Middle Aged ; Osseointegration ; Osteotomy ; Sinus Floor Augmentation
6.Coexistence of Pancreatic Carcinoma and Pancreatic Tuberculosis: Case Report.
Zhen Jiang ZHENG ; Hao ZHANG ; Guang Ming XIANG ; Jun GONG ; Gang MAI ; Xu Bao LIU
Gut and Liver 2011;5(4):536-538
Pancreatic tuberculosis (TB) is extremely rare and mimics pancreatic carcinoma both clinically and radiologically. This paper discusses the occurrence of 2 heterogeneous masses located in the head and tail of the pancreas in an adult male. In this patient, laparotomy was performed because of the high suspicion of pancreatic carcinoma. Intraoperative fine needle aspiration biopsy revealed the coexistence of pancreatic carcinoma with pancreatic TB, and a combined resection of the distal pancreas and spleen was successfully performed. Following surgery, the patient received standard chemotherapy for TB. At 7-month follow-up, computed tomography showed resolution of the mass in the pancreatic head. Clinicians must maintain a high index of suspicion for pancreatic TB in patients with pancreatic masses. The coexistence of malignancy and TB should be considered when patients present with multiple pancreatic masses.
Adult
;
Biopsy
;
Biopsy, Fine-Needle
;
Follow-Up Studies
;
Head
;
Humans
;
Laparotomy
;
Male
;
Pancreas
;
Pancreatic Neoplasms
;
Spleen
;
Tuberculosis
7.Pancreatic Panniculitis Associated with Acinar Cell Carcinoma of the Pancreas: A Case Report.
Zhen Jiang ZHENG ; Jun GONG ; Guang Ming XIANG ; Gang MAI ; Xu Bao LIU
Annals of Dermatology 2011;23(2):225-228
Pancreatic panniculitis is a rare type of disorder associated with pancreatic diseases. We describe here a case of 54-year-old man who was admitted to the Department of Dermatology with the diagnosis of erythema nodosum. The patient presented with a 9-month history of painful erythematous nodules on the extremities, joint pain and swelling, and weight loss. A highly elevated level of pancreatic lipase was found on the laboratory examinations. The biopsy specimens from the skin lesions showed subcutaneous fat necrosis. Abdominal computed tomography (CT) revealed a large mass with central necrosis in the body and tail of the pancreas. Distal pancreatectomy, splenectomy and partial transverse colectomy were successfully performed on day 17 of the hospitalization. The histopathologic findings supported the diagnosis of acinar cell carcinoma of the pancreas (ACCP). Postoperatively, the level of serum lipase returned to normal, and the skin lesions and joint manifestations gradually regressed. However, the swelling did not significantly resolve in the left knee. In view of the non-specific clinical presentation of this disease, clinicians should be alert and have a high index of suspicion for pancreatic panniculitis.
Acinar Cells
;
Arthralgia
;
Biopsy
;
Carcinoma, Acinar Cell
;
Colectomy
;
Dermatology
;
Erythema Nodosum
;
Extremities
;
Hospitalization
;
Humans
;
Joints
;
Knee
;
Lipase
;
Middle Aged
;
Necrosis
;
Pancreas
;
Pancreatectomy
;
Pancreatic Diseases
;
Panniculitis
;
Skin
;
Splenectomy
;
Subcutaneous Fat
;
Weight Loss
8.Distribution of systemic vascular resistance disorders and its related factors in Hebei province.
Xiao-mei ZHOU ; Bao-shen QI ; Cheng-li XU ; Shao-mei HAN ; Guang-jin ZHU
Acta Academiae Medicinae Sinicae 2006;28(2):249-252
OBJECTIVETo analyze the distribution features of systemic vascular resistance (SVR) disorder in healthy subjects in Hebei province.
METHODSSVR and systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), pulse pressure (PP), heart rate (HR), cardiac output (CO), cardiac index (CI), stroke volume (SV), stroke index (SI), left ventricular ejection time (LVET), left cardiac work (LCW) and cardiovascular function were determined with Bioz. com Cardio Dynamics. Total cholesterol (TC), triglyceride (TG) and influencing factor were tested by automated hematology analyzer in 999 healthy subjects living in Hebei province.
RESULTSSVR disorder gradually increased with the ageing in healthy subjects and the prevalences of SVR disorders was higher among females than among males (P < 0.001). SVR was positively correlated with SBP, DBP, MAP, PP, LVET, body mass index (BMI), TC, and TG, and was inversely associated with HR, CO, CI, SV, SI, LCW, and arterial compliance (AC). CO and MAP were independent influencing factors with SVR.
CONCLUSIONSVR disorder is associated with age, sex, and blood pressure in populations in Hebei province and may be a marker of vascular injury.
Adolescent ; Adult ; Age Factors ; Aged ; Blood Pressure ; Body Mass Index ; Cardiac Output ; Female ; Hemodynamics ; physiology ; Humans ; Male ; Middle Aged ; Risk Factors ; Sex Factors ; Vascular Capacitance ; Vascular Diseases ; physiopathology ; Vascular Resistance
9.Study on the function of decoction for invigorating the kidney and improving blood circulation to thrombosis on rabbit blood stasis model.
Xiao-ping ZHAN ; Mei SUN ; Xiao-ying JIN ; Chen-yu JIN ; Xi-hong XU ; Guang-ming QIN ; Juan BAO
China Journal of Chinese Materia Medica 2006;31(5):411-413
OBJECTIVETo evaluate the effect of decoction for invigorating the kidney and improving blood circulation to thrombosis and pathology on rabbit blood stasis model.
METHODThirty rabbits were ramdomly divided into normal group, model group, high dose group, low dose group and Xue Shuan Ning group. Tissue-type plasminogen activator (t-PA), plasminogen activator inhibitor (PAI), fibrinogen (Fbg) and D-dimer (DD) were investigated after those rabbits had been treated. One rot was solected randomly from each group to observe pathological changes.
RESULTThere were significant differences in t-PA, PAI, Fbg and DD between normal group and other groups is very obvious (P < 0.01) . Between groups of high dose low dose Xue Shuan Ning and model, the statistical differeces were significant, as well as between groups of high dose, low dose and Xue Shuan Ning groups (P < 0.05). However, there was no statistical difference between high dose group and high dose group (P > 0.05). The pathological changes in model group were most serious, those in Xue Shuan Ning were less serious. There were slight pathological changes in high dose group and low dose group.
CONCLUSIONModels ware made successfully. High dose group and low dose group have stronger effect on thrombosis than Xue Shuan Ning group.
Animals ; Blood Viscosity ; drug effects ; Dose-Response Relationship, Drug ; Drug Combinations ; Drugs, Chinese Herbal ; administration & dosage ; isolation & purification ; pharmacology ; Female ; Fibrin Fibrinogen Degradation Products ; metabolism ; Fibrinogen ; metabolism ; Hematocrit ; Male ; Plants, Medicinal ; chemistry ; Plasminogen Inactivators ; blood ; Rabbits ; Random Allocation ; Thrombosis ; blood ; pathology ; Tissue Plasminogen Activator ; blood
10.The effect evaluation of a new tuberculosis management model in rural areas of Guangxi.
Guang-bao XU ; Fei-ying LIU ; Qi-ming FENG ; Xin-yuan LIANG ; Li SU
Chinese Journal of Preventive Medicine 2011;45(1):30-35
OBJECTIVETo explore the effect of new model for tuberculosis (TB) control and management, and provide a scientific basis and justification for making TB control strategies in rural communities.
METHODSAmong those townships with low TB service accessibility by the county TB control institute in Guangxi Xingye county (population of 679 thousands), four townships with total population of 152 518 and inconvenient transportation, were selected as the experimental group to conduct a new model research project.Based on the accessibility for community services, setting diagnosis and treatment management centers in township hospitals, employing family treatment supporters to supervise the treatment process. The TB cases of the base-line and the project expiration of the experimental group were 44 and 117. Meanwhile, three townships including Dapingshan, Longan and Gaofeng in the county with the similar condition and total population of 133 303 were selected as the control group. The control group conducted the provisions of national TB control program in the county TB clinic management. The TB cases of the base-line and the project expiration of the control group were 56 and 110. By double-direction comparison method, the effect of the new model was evaluated through TB patients detection, treatment outcomes and TB control management data. SPSS 13.0 statistical software was adopted and Chi-square test was used for analyzing technical data.
RESULTSAfter two-year project research implementation, in the experimental group the detection rate of new smear-positive TB patients increased from 16.39/100 000 (25/152 518) to 51.14/100 000 (78/152 518) (χ(2) = 27.281, P < 0.01), the cure rate of new smear-positive cases increased from 71.4% (15/21)to 91.1% (51/56) (χ(2) = 4.812, P < 0.05), and the completing treatment rate in newly diagnosed smear-negative cases improved from 23.5% (4/17)to 71.4% (15/21) (χ(2) = 8.622, P < 0.01); the loss rate of newly diagnosed smear-positive cases dropped from 23.8% (5/21) to 0.0% (0/56) (χ(2) = 10.608, P < 0.01), and the loss rate of newly diagnosed smear-negative cases decreased from 64.7% (11/17) to 4.8% (1/21) (χ(2) = 15.624, P < 0.01). Meanwhile, the cure rate of new smear-positive cases in the experimental group, 91.1% (51/56), was higher than the control group, 72.0% (36/50) (χ(2) = 6.531, P < 0.05). The loss rate of newly diagnosed smear-positive cases in the experimental group (0.0% (0/56)) was lower than the control group (16.0% (8/50)) (χ(2) = 7.534, P < 0.01). During the project implementation, in the experimental group the on time rate of taking medicine, 91.5% (107/117) and receiving medicine, 100.0% (117/117), the reexamining sputum ratio, 83.6% (98/117) were higher than that in the control group: 81.8% (90/110), 92.7% (102/110) and 64.5% (71/110). The differences were statistically significant (χ(2) = 4.589, 8.820 and 11.005, P < 0.05).
CONCLUSIONThe new management model had been proved effective. It can improve TB case detection and cure rates, reduce the loss rate of patients, and improve patient treatment and management conditions as well.
China ; Communicable Disease Control ; methods ; Humans ; Outcome Assessment (Health Care) ; Rural Health ; Tuberculosis ; prevention & control