Objective To analyze and compare images of radial head fracture of 50 patients acquired by computed radiology(CR),coronal plane and axial plane of CT scan.And to determine routine plane of CT scan for radial head fracture.Methods Images of of radial head were acquired by CR,coronal plane and axial plane of CT scan on 50 patients with radial head fracture initially diagnosed by orthopedists. classify all the cases of radial head fracture into type Ⅰ、Ⅱ、Ⅲ and Ⅳ according to the classification proposed by Mason.Results The positive incidence of CT and CR were 96%(48)and 78%(39) respectively.Cases of 94%o(47)through CT coronal scan and 82%(41)eases through CT axial scan were exactly classified.Conclusion The designation of the plane of CT scan is significant to the classification of the radial head fracture.Coronal plane CT scan can meet the need of imaging clinical classification and is recommended to be routine plane of radial head fracture.In order to ensure the exact classification axial plane and 3D reconstruction technique should be added for type Ⅲ and type Ⅳ of radial head fracture.

Endophytic fungi Penicillium dangeardii, isolated from Lysidice rhodostegia Hance root, was fermented and the secondary metabolites were studied. By means of Sephadex LH-20 column chromatography, ODS column chromatography and PHPLC over the fermented culture, 5 compounds were isolated. By using ESI-MS and NMR, the structures of the compounds were determined as N-[9-(β- D-ribofuranosyl)-9H-purin-6-yl]-L-aspartic acid (1), 3-caffeoylquinic acid (2), 4-caffeoylquinic acid (3), and 5-caffeoylquinic acid (4), 3-hydroxy-benzoic acid-4-O-β-D-glucopyranoside (5).
Biological Factors ; chemistry ; isolation & purification ; metabolism ; Endophytes ; chemistry ; metabolism ; Fabaceae ; microbiology ; Fermentation ; Molecular Structure ; Penicillium ; chemistry ; metabolism ; Secondary Metabolism

OBJECTIVETo evaluate the effect and adverse effects of arsenic trioxide (As2O3) in the treatment of primary hepatocarcinoma patients, and conduct the pharmacokinetics study.

METHODSA total of one hundred and eleven advanced primary hepatocarcinoma patients in five centers were treated with As2O3 injection 7 - 8 mg/m(2) i.v. qd for 14 days and was repeated after 7 - 14 days. Evaluation of the clinical response and adverse effects was conducted after two cycles of treatment. The patient who had reached partial PR and SD was treated continuously until disease progression or intolerance.

RESULTSAmong the 102 patients evaluable for clinical efficacy analysis, there were 7 PR, 71 SD and 24 PD, the response rate was 6.9% and the clinical benefit rate was 76.5%. The quality of life was improved in 22.5% of patients. The pain relief rate was 71.7%, time to progress (TTP) was 97 days, and the median survival time (MST) was 195 days. The major adverse effects were reversible WHO I-II grade gastrointestinal reactions and bone marrow suppression. The results of pharmacokinetic study showed that the distribution and elimination characteristics in vivo was found to be a two-compartment model. The plasma elimination half-life was (23.94 ± 18.39) h.

CONCLUSIONSAs2O3 is effective in the management of primary hepatocarcinoma, with a significant analgesic effect. To some extent, it can extend TTP and MST in advanced liver cancer patients, while the treatment is well tolerated in the majority of patients.

Adult ; Aged ; Antineoplastic Agents ; administration & dosage ; adverse effects ; pharmacokinetics ; therapeutic use ; Arsenicals ; administration & dosage ; adverse effects ; pharmacokinetics ; therapeutic use ; Carcinoma, Hepatocellular ; blood ; drug therapy ; pathology ; Disease Progression ; Female ; Follow-Up Studies ; Half-Life ; Humans ; Injections ; Leukopenia ; chemically induced ; Liver Neoplasms ; blood ; drug therapy ; pathology ; Lung Neoplasms ; drug therapy ; secondary ; Lymphatic Metastasis ; Male ; Middle Aged ; Nausea ; chemically induced ; Neoplasm Staging ; Oxides ; administration & dosage ; adverse effects ; pharmacokinetics ; therapeutic use ; Quality of Life ; Remission Induction ; Survival Rate ; Vomiting ; chemically induced

Objective To evaluate the bioequivalent between the two kinds of glipizide tablets.Methods With two-cycle crossover trial was design, 24 healthy male subjects were given a single oral dose 5 mg of glipizide test preparation and reference preparation.Serum samples were collected at different time points before administration and after adminis-tration.The plasma concentrations were measured by HPLC -MS/MS method.The pharmacokinetic parameters and relative bioavailability were calculated by WinNonlin 6.1 software.Results The main pharmacoki-netic parameters of the test and reference glipizide tablets were as fol-lows: tmax were ( 3.40 ±1.54 ) and ( 3.71 ±1.30 ) h, Cmax were (471.88 ±108.10 ) and ( 480.58 ±132.63 ) μg · L-1 , t1/2 were (5.15 ±1.31) and(5.32 ±1.27)h, AUC0-t were (2805.71 ±592.61 ) and (2873.40 ±697.57 )μg· h-1 · L, respectively.F0-t and F0-∞ of test preparation were ( 105.77 ±27.84 )% and ( 105.28 ±27.63 )% re-spectively.Conclusion The glipizide tablets test and reference are bio-equivalent.

·AIM: To investigate the prevalence of myopia among primary and middle school students aged 7 to 18 in Longkou City, Shandong Province, and to provide a scientific basis for prevention and control of myopia. ·METHODS: The students aged 7 to 18 were enrolled through the method of stratified random and cluster sampling by the unit of schools and were investigated in Longkou, Shandong Province in 2015. A total of 58 schools were selected and 61 036 students were effectively sampled. All the subjects were divided into three- tiers based on geographical location: urban, rural-urban continuum, and rural areas. All the subjects were examined with the visual acuity and non -cycloplegic objective fraction. Microsoft Excel worksheet was used to establish a database, and SPSS 21. 0 software was used for statistical analysis. ·RESULTS: The prevalence of total myopia in the sample population of students of Longkou in 2015 was 49. 81% from 7 to 18 years old. The overall prevalence of myopia increased fastest from 11 to 12 years old. And the prevalence of mild myopia of students aged 13 was highest. The prevalence of total myopia were 46. 41% for boys and 53. 39% for girls, which showed the prevalence of girls was higher than the boys'. The prevalence of myopia in urban, rural- urban continuum, and rural areas were 55. 18% , 49. 75% , 44. 47% , respectively, and the prevalence of myopia in urban areas was the higher than the rural-urban continuum and the rural areas. The prevalence of total myopia gradually increased with age (rs=0. 943, P<0. 05). ·CONCLUSION: The results of the investigation showed a high prevalence of myopia among primary and middle school students in the city of Longkou, and gradually increased with age. The overall myopia prevalence for girls was higher than boys, and the prevalence was highest in urban areas.

OBJECTIVETo study the reconstruction of partial defects at the end of the thumbs and other fingers with microsurgical free toe flaps.

METHODS21 partial defects (19 cases) at the end of thumbs and other fingers were reconstructed with microsurgical free toe flaps taking from the corresponding toe part.

RESULTSAll the free flaps survived. The patients were followed up for 3 - 6 months. The aesthetic and functional results were both satisfactory. The two-point-discrimination distance was 4 - 6 mm.

CONCLUSIONSThe microsurgical free toe flaps have good therapeutic effect for the reconstruction of partial defects at the end of the fingers.

Adolescent ; Adult ; Female ; Finger Injuries ; surgery ; Humans ; Male ; Reconstructive Surgical Procedures ; methods ; Skin Transplantation ; Surgical Flaps ; Thumb ; injuries ; surgery ; Toes ; surgery ; Young Adult

OBJECTIVETo evaluate the safety and efficacy of individual cylindrical abdominoperineal resection (CAPR) for locally advanced low rectal cancer.

METHODSFrom June 2011 to February 2012, 11 patients with locally advanced low rectal cancer underwent individual CAPR. There were 7 male and 4 female patients, aged from 32 to 74 years with a median of 64 years. Forty-seven patients underwent classic CAPR from January 2008 to February 2012. Preoperative and postoperative parameters such as clinical information of patients, tissue morphometry and complications were compared.

RESULTSIn the individual surgical group, 6 patients were treated with one side levator ani muscle totally or partially reserved, 3 patients with sacrococcyx reserved, and 2 patients with dissection close to the anterior rectal wall. Compared with classical surgery, the individual surgical specimens of horizontal section area ((2197 ± 501) mm(2)) and intrinsic muscle layer outer area ((1722 ± 414) mm(2)) were small, but the difference was not statistically significant (P = 0.150 and 0.167). The operative time, intraoperative blood loss, circumferential resection margin, total cross sectional tissue area, cross sectional tissue area outside the muscularis propria and bowel perforation rate between the two groups were not significantly different. Individual CAPR showed less incidence of chronic perineal pain (2/11, χ(2) = 6.116, P = 0.013) and sexual dysfunction (2/9, χ(2) = 4.412, P = 0.036) compared with classic CAPR.

CONCLUSIONSIndividual CAPR has the potential to reduce the risk of chronic perineal pain and sexual dysfunction without influencing the radical effect when compare with classic CAPR for the treatment of low rectal cancer.

Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Perineum ; surgery ; Postoperative Complications ; epidemiology ; Rectal Neoplasms ; pathology ; surgery ; Rectum ; surgery ; Survival Rate ; Treatment Outcome

Objective To investigate the pharmacokinetics of olopata-dine hydrochloride tablets in healthy volunteers. Methods Twelve healthy volunteers were divided into receiving orally a single dose of 5, 10,20 mg olopatadine hydrochloride tablets respectively. The plasma and urinary samples were determined by HPLC-MS/MS. Results The main pharmaeokinetic parameters of three different dosages (5,10,20 mg) were as follows: C_(max) were (76.73±26.61) , (133.61±61.63) and (270.44±115.19) μg·L~(-1); t_(max) were (0.75±0.19), (0.96± 0. 29) and (0. 83±0. 32) h; t_(1/2) were (5.20±2. 47), (6. 82±3.04) and (6.87±3.06) h; AUC_(0-t) were (246.70±66.07), (439. 19± 185.03) and (904.69±300.21) μg·h·L~(-1) and AUC_(0-∞) were (248.36±65.81), (442. 02 ± 186. 46) and (907.49±299. 92) μg·h·L~(-1). Mean of excretory rate of three different dosages (5, 10, 20 mg) was 54. 6%. Conclusion The value of C_(max) and AUC will increase following the increase of the doses. The pharmacokinetic characteristic of olopatadine hydrochloride in Chinese healthy vohmteers were fitted with linear kinetic model. It is showed that the sex-related differences did not exist in the main pharmacokinetic parameters between males and females by analysis of variance.

Objective To evaluate the clinical efficacy and safety of amifostine on elderly acute leukemia patients receiving chemotherapy.Methods Fifty-eight patients with acute leukemia treated with chemo-therapy and amifostine were recruited in this study and then divided into two groups, 28 cases in elderly group (≥60 years) and 30 cases in control group (<60 years).All the patients were given amifostine 600 mg· m-2 through intravenous injection 15 to 30 minutes prior chemothe-rapy for 4 cycles.The data of the influence of amifostine on chemotherapy-induced adverse reactions as well as patients′blood pressure were compared in two groups.Results There was no statistical difference in incidence rates of chemotherapy -induced adverse reactions in two groups (P>0.05).After chemotherapy, there were 82 (80.4%) and 102 (80.3%) cases showing decreasing systolic blood pressure in elderly group and control group, respectively, and 71 ( 69.6%) and 83 ( 62.9%) cases showing decreasing diastolic blood pressure ( P >0.05).Conclusion The application of amifostine on elderly acute leukemia patients who has received chemotherapy is safe and could relieve chemotherapy-induced adverse reactions.

Objective To investigate the clinical efficacy and safety of CHOP chemotherapy regiment combined with thalidomide in the treatment of aggressive non-hodgkin′s lymphoma.Methods Seventy-two cases of aggressive non-hodgkin′s lymphoma were recruited in this study and randomly divided into control group ( n =35 ) and treatment group (n=37). Patients in the control were given CHOP chemotherapy ( cyclophosphamide 600 mg ? m-2 intravenous injection, day 1+epirubicin 40 mg? m-2 ntravenous injection, day 1+vinblastine 1.4 mg? m-2 ntravenous injection, day 1+dehydrocortisone 50 mg? m-2 , orally, day 1-7).Patients in the treatment group were given CHOP chemotherapy regiment combined with thalidomide ( thalidomide 200 mg, day 1 -14, orally, at the second phrase thalidomide 400 mg, day 1-14).After 4 cycles treatment, the objective response rate, 1 and 2 year survival rate and chemotherapy associated toxicity were assessed between the two groups. Results The objective response rate were 78.38% and 57.14% in the treatment and control group respectively with the treatment group statistical higher than control group( P<0.05). The 1 and 2 years survival rate were 65.71%and 40.00%in the control group which was significant lower than that in the treatment group(1 and 2 years survival rate 81.08%, 62.16%, P<0.05) .The chemotherapy associated toxicity such as granulopenia, nausea and vomiting, alopecie and et al had no statistical difference between the two groups (P>0.05).Conclusion CHOP chemotherapy regiment combined with thalidomide can improve the objective response rate without increasing the toxicity in treatment of aggressive non-hodgkin′s lymphoma.