2.Glomerulocystic kidney disease: report of a case.
Yan ZHU ; Jing ZHAO ; Guang YU ; Yong-wei YU
Chinese Journal of Pathology 2011;40(7):488-489
4.Non-iridoid constituents from roots of Gentiana straminea
Shihu WEI ; Changyuan YU ; Liming LU ; Guang CHEN
Chinese Traditional and Herbal Drugs 1994;0(08):-
Objective To study the non-iridoid constituents from the roots of Gentiana straminea.Methods The compounds were repeatedly separated and purified on column chromatography of silica gel,Sephadex LH-20,and ODS,and their structures were identified on the basis of spectral and chemical methods.Results Twelve compounds were isolated from 70% ethanol extract of G.straminea and were identified as(-)-syringaresinol-4,4′-bis-?-O-D-glucopyranoside(1),gentiaphyllide-D(2),erythrecentaurin(3),macrophyiioside D(4),gentiaphyllide-E(5),roburic acid(6),uvaol(7),?-sitosterol(8),daucosterol(9),gentianose(10),?-glucose(11),and ?-glucose(12),respectively.Conclusion Compounds 1-6 and 10 are isolated from this plant for the first time.
5.Effect of daidzein on hepatocellular carcinoma SMMC7721 cell proliferation and tumor stem cell CD133 expression
Min ZHANG ; Hongzhi SUN ; Wei WANG ; Guang BAI ; Xiaodong YU
Chinese Journal of Biochemical Pharmaceutics 2014;(3):28-30
Objective To discuss the effect of daidzein on hepatocellular carcinoma SMMC7721 cell proliferation CD133 expression on tumor stem cell.Methods Hepatocellular carcinoma SMMC7721 cells were cultured,digested and passaged,and divided into six groups with different drug:control group with no daidzein,100 μg/mL daidzein group,200μg/mL daidzein group,300μg/mL daidzein group,400μg/mL daidzein group ,500μg/mL daidzein.The inhibition ratio,hexokinase,alkaline phosphatase and CD133 levels in SMMC7721 cell were detected and compared at 24 h,48 h,72 h among those groups. Results The inhibition ratio was increased by Daidzein dose increasing,and decreased apparently by times extending,especially in 400μg/mL and 500μg/mL daidzeingroups.Compared with control group,the hexokinase and alkaline phosphatase activity and CD133 expression were decreased apparently in groups treated with daidzein(P<0.01).The more the dose,the higher the drop(P<0.01).Conclusion Daidzein can inhibit hepatocellular carcinoma SMMC7721 cell proliferation,and inhibit CD133 expression on tumor stem cell.
6.Adaptive Reaction of Actin Cytoskeleton in Podocyte Structure of Glomerulus
yu-lin, KANG ; guang-hua, ZHU ; wei-xun, HE
Journal of Applied Clinical Pediatrics 1992;0(05):-
Actin cytoskeleton in podocyte is a complicated network structure,and the stability of this structure depend on many proteins which located in slit diaphragm,the apical membrane domain and the basal membrane domain with the stimulus of mechanical stress,the actin cytoskeleton can be adaptive regulated to maintain the normal function of glomerulus,and several signal pathways involve in the process,such as RhoA/Rho kinase signal pathway and TRPC6.
7.The application of system epidemiology theory and methodology in occupational epidemiology
ZHANG Si yu JIA Guang HU Wei jiang SUN Xin
China Occupational Medicine 2022;52(04):439-
Abstract:
Occupational epidemiology aims to explore the effect of occupational hazards on the health of workers and understand
,
their mechanisms. It plays an important role in occupational health and occupational medicine.Currently occupational
, ,
exposures in the workplace are complex and diverse and multiple factors affect workers´ health at the same time. Therefore it
is important to elucidate the pathogenesis of occupational disease caused by occupational hazards and implement early
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intervention. System epidemiology collects data on multi level exposure and multi omics information to conduct network analysis
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on the relationship amongrisk factors. and to study the mechanisms of exposures and health outcomes based on multi level data.
, , , ,
Using the study design of system epidemiology occupational environmental lifestyle and social factors are combined as a
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system to evaluate the health of workers which can better evaluate the adverse health effects caused by occupational hazards.
- , ,
The studies base on multi omics design will explore the pathogenesis of occupational diseases at the molecular cellular and
tissue levels to evaluate the impact of occupational hazards on workers´ health and to explore interventions from multiple
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perspectives to reduce the occurrence of occupational or work related diseases.
8.Epithelioid angiosarcoma after radical mastectomy for breast carcinoma: a case report.
Hong-ji DING ; Guo-guang WEI ; Li-qun YU ; Qi-song WU ; Yan-guang DONG
Chinese Journal of Pathology 2006;35(10):637-638
Aged
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Antigens, CD34
;
metabolism
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Breast Neoplasms
;
metabolism
;
pathology
;
therapy
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Chemotherapy, Adjuvant
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Combined Modality Therapy
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Epithelioid Cells
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pathology
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Female
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Follow-Up Studies
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Hemangiosarcoma
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metabolism
;
pathology
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Humans
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Immunohistochemistry
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Mastectomy, Radical
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Neoplasms, Second Primary
;
metabolism
;
pathology
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Radiotherapy, Adjuvant
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Vimentin
;
metabolism
9.The study of expression of matrix metaUoproteinases-2 in patients with colorectal cancer
Ya MA ; Guang-Ling CAI ; Guang-Yin YU ; Wei-Hua YIN ; Li CHEN ;
Chinese Journal of Primary Medicine and Pharmacy 2005;0(11):-
Objective Research the correlation between expression of MMP-2 in colorectal cancer and patho- logical factors,or biological behaviors in colorectal cancer.Methods The expression of MMP-2 in 68 cases with col- orectal cancer were detected by immunohistochemical staining.Results The expression of MMP-2 in colorectal can- cer was not correlated with tumor region and histologic type,but related with depth of tumor invasion and metasta- sis.The frequency of positive cases in patients with colorectal cancer with of lymph,node metastasis was significantly higher than that in patients without lymph node metastasis(P
10.Study of biomechanical properties of mucosa scars after cleft palate surgery.
Min HOU ; Guang-Yu SHI ; Wei QIU ; Lan-Cheng ZHANG ; Tian-Ping YU ; Chun-Ming LIU
Chinese Journal of Plastic Surgery 2013;29(6):453-456
OBJECTIVETo explore biomechanical properties and stress-strain of mucosa scars after cleft palate surgery.
METHODSAfter the model of mucosa scars was made, the mucosa scars and normal mucosa were excised and examined immediately by tensionometry.
RESULTSThe mucosa scars after cleft palate surgery were compared with normal mucosa. The Poisson's ratio of mucosa scars and normal mucosa was 0.5 and 0.49, respectively, showing no significant difference between the two groups. The ultimate Young's modulus of mucosa scars was about 24.22 MPa, however, it declined to 3.32 Mpa in normal mucosa.
CONCLUSIONSThe mucosa scars after cleft palate surgery are biomechanically weaker than normal mucosa. It can be used for further research, such as maxillary orthognathic surgery, distraction osteogenesis, and orthodontic treatment.
Biomechanical Phenomena ; Cicatrix ; physiopathology ; Cleft Palate ; surgery ; Humans ; Mouth Mucosa ; physiopathology ; surgery ; Osteogenesis, Distraction ; Osteotomy, Le Fort