Aim The study is to observe the clinical efficacy of losartan in hypertentive patientswith left ventricular hypertrophy. Methods 21 case were given losartan for 20 wk and 24h ambulatory blood pressure monitoring and color doppler echocardiography were per-formed in the patients before and after treatment.Results The 24 h SBP, 24 h DBP,dDBP, nSBP were from (151 ? 15) 、(93 ?9)、(155 ? 15)、(96 ? 10)、(146 ? 16)、(88 ? 11)mmHg before treatment to (132 ? 11)、(82 ? 8)、(137 ? 12)、(88 ? 9)、(120 ? 9)、(120 ? 15)、(74 ? 9) mmHg after treatment respectively and the IVST, PWT and LVMI were from(14.2 ? 1 .5) mm、(13. 9 ? 1. 45) mm、(152. 1 ? 24. 2) g? m2-1 BSA before treatment to(12. 1 ? 1. 31) mm、 (12. 2 ? 1. 41) mm、(130. 6 ? 23. 1) g? m2-1 BSA after treatment re-spectively. All the parameters after treatment in the patients were significantly decreased ascompared with those before treatment (P

Fourteen compounds were isolated by column chromatography from the ethyl acetate extract of the seeds of Brassica campestris. Their structures were elucidated by physicochemical properties and spectroscopic data analysis. The isolated compounds were respectively identified as (5Z,7E)-4, 4-dimethyl-5-acetyl-5, 7-nonadienoic acid (1), indole-3-carboxaldehyde (2), blumenol A (3), vinylsyringol (4), sinapinic acid (5), sinapic acid ethyl ester (6), protocatechuic acid (7), crinosterol (8), campesterol (9), 7-oxo-stigmasterol (10), kaempferol (11), 2,5-dihydroxybenzoic acid (12), syringic acid (13) and daucosterol (14). Compound 1 was a new compound and the other compounds were isolated from this plant for the first time except for compounds 4, 5 and 13.
Brassica ; chemistry ; Drugs, Chinese Herbal ; chemistry ; isolation & purification ; Molecular Structure ; Seeds ; chemistry ; Spectrometry, Mass, Electrospray Ionization

Objective To study the changes of serum level of high mobility group box-1(HMGB- 1)in patients with multiple trauma in order to forecast organ dysfunction(OD)and deaths.Methods The optical densities of HMGB-1 in serum of 35 patients with multiple trauma were determined on 1st,3rd, and 7th days after trauma,and the incidence of organ dysfunction and deaths were evaluated,then analyzed statistically to learn the relation between the serum levels of HMGB-1 and deaths with an attempt of predic- ting the incident of organ dysfunction and deaths.Results (1)As OD was concerned,there was a statis- tically significant difference in optical density of HMGB-1 on 1st and 3rd days between the two groups of multiple injury patients(t=4.411,P

Objective To study the change and the significance of T-lymphocyte immune function in peripheral blood in population living in arsenic-contaminated area. Methods Fifty-three cases of patients with arsenism symptoms were selected into experimental group, inhabitants who had no chronic arsenism symptoms into control group in the endemic area of Shuocheng District, Shuozhou City, Shanxi Province in 2006. Vein blood samples were taken and analyzed with SAP assay to measure the percentage of CD3+ ,CD4+ and CD8+ T-cells. Results It was found that the percentage of CD3+, CD4+, and CD4+/CD8+ [(41.89 ± 11.58)%, (25.60 ± 9.05)% and 1.02 ± 0.41] in the experimental group was lower than that in the control group [(68.38 ± 7.23)%, (39.17± 4.28)% ,1.69 ± 0.56, t = 13.61,18.72,14.79, all P < 0.05], while there was no statistical differences of CD8+ [(25.30 ± 6.85)%] compared to the control group[(23.54 ± 8.35)%,t = 3.07,P > 0.05]. The gender-related effect of arsenic on CD4+ and CD8+ was found by multiple linear step regression analysis(t = - 3.05, - 4.30, all P < 0.05). In case group, there were no statistical differences in CD3+, CD4+, CD8+ and CD4+/CD8+[(40.65±10.06)%, (24.48 ± 6.29)%, (24.52 ± 8.16)%,0.98 ± 0.25] between males and females [(43.07±12.96)%, (26.77±3.12)%, (26.50 ±9.32)%, 1.07 ±0.41, t = - 0.76,3.05,0.30,2.10, all P > 0.05]. Conclusions The immune function of T-lymphocytes of patients with chronic arsenism has been suppressed. It is of active significance to detect T-lymphocyte subpopulation in peripheral vein in patients with chronic arsenism aiming at estimating the function of cell immune and providing early diagnosis index.

Aged ; Humans ; Male ; Middle Aged ; Penis ; innervation ; Prostatectomy ; methods ; Prostatic Neoplasms ; surgery

In this paper, we expatiate the advance of Tricholoma matsutake including distributing, environment, pure culture, domesticating cultivation and artificial forcing breeding in the area of Changbai Mountain of China.

Comparative analysis of characteristic of species and esterase-isoenzyme of isolates of Polyporus umbel-latus from different regions were processed. The results indicated that isolates of Jizhaoling ( Z) and Zhushiling (ZJ) have significant differences in characteristic, and enzymatic band types of the two species also have significant differences. The homology at genetics between the two isolates is 0% , and consanguinity between the two i-solates is the farthest.

Objective To explore the incidence of operation complications and clinical curative effect of microsurgical vascular decompression on treatment of patients with common cranial nerve diseases. Methods One hundred and sixty-six patients with hemifacial spasm and 45 patients with primary trigeminal neuralgia,admitted to our hospital from September 2006 to May 2011,were collected in our study; all the patients under,vent microvascular decompression via a posterior sigmoid sinus key hole approach.Complications were analyzed after surgery for trigeminal neuralgia and hemifacial spasm patients to find the difference on complications between these 2 diseases. And at least 3-month clinical follow-up after microvascular decompression surgery was carried out to note the differences on disappearance of cranial nerve symptoms between 3 d and 3 months after the surgery. Results Postoperative fever in the patients with hemifacial spasm and trigeminal neuralgia was seen in 51 and 14 patients,prosopoplegia in 7 and 1 patient,hearing impairment in 4 and 2 patients,incisional cerebrospinal fluid leakage in 5 and 2 patients, and intracranial infection in 3 and 2 patients, respectively. Symptom disappearance was noted in 109 patients with hemifacial spasm 3 d after the surgery and in 153 patients 3 months after surgery with a cure rate up to 92.2％; 44 patients with disappearance of symptoms during the 3rd d to the 3rd months of surgery had delayed healing. The symptom disappearance was observed in 40 patients with trigeminal neuralgia 3 d after the surgery and in 42 patients 3 months after the surgery,with a cure rate reaching 93.3％. Conclusion No significant difference in the incidence of operation complications is noted between patients with trigeminal neuralgia and hemifacial spasm treated by microvascular decompression via a posterior sigmoid sinus key hole approach; the surgery enjoys exact effectiveness; and postoperative patients with hemifacial spasm may gradually get recovery in a short term.

Semi-fixed mandibular lingual arch expansion appliance is composed of a mandibular molar band, a keyway and arch expansion spring. The arch expansion spring are used to expand maxillary arch symmetrically or asymmetrically when bolts of the two ends are inset into keyways. Dental arch expansion appliance for 25 patients with mandibular arch stenosis showed that semi-fixed mandibular lingual arch expansion had good effect and could be used to expand mandibular arch.
Dental Arch ; Humans ; Mandible ; pathology ; Orthodontic Appliances ; Palatal Expansion Technique

OBJECTIVETo explore the effects of recombinant human growth hormone (rhGH) on the serum levels of cytokines in severely burned patients.

METHODSThirty-six burn patients were enrolled in the study and were randomly divided into 3 groups according to the rhGH dosage used, i.e. small (0.3 IU.kg(-1).d(-1), A), large (0.6 IU.kg(-1).d(-1), B) dose groups and control group (C, with normal saline). The rhGH was administered beginning from 3 postburn days (PBDs) and lasted for 20 days. The dynamic changes in the serum levels of TNFalpha, IL-6, IL-8 and LPS at different time points were observed.

RESULTSWhen compared with those in C group, the serum levels of TNFalpha, IL-6 in A, B groups were decreased, especially in B group with earlier decrease and bigger range (P < 0.01). Simultaneously, the serum LPS level was decreased accordingly with evident positive correlation with the change in those cytokines (r = 0.9723, P < 0.01). But there was no obvious difference in serum IL-8 level among A, B and C groups (P > 0.05).

CONCLUSIONrhGH might decrease the production of postburn inflammatory mediators, especially in higher dose in dose-dependent manner for some degree. The clinical application of rhGH might be a supplementary measure in preventing and ameliorating postburn SIRS and MODS in severely burned patients.

Adult ; Burns ; blood ; complications ; drug therapy ; Cytokines ; blood ; drug effects ; Dose-Response Relationship, Drug ; Female ; Human Growth Hormone ; pharmacology ; therapeutic use ; Humans ; Interleukin-6 ; blood ; Interleukin-8 ; blood ; Lipopolysaccharides ; blood ; Male ; Middle Aged ; Multiple Organ Failure ; etiology ; mortality ; Recombinant Proteins ; pharmacology ; therapeutic use ; Survival Rate ; Time Factors ; Tumor Necrosis Factor-alpha ; metabolism