1.Two cases with crush syndrome complicated with pulmonary edema.
Sheng HAO ; Guang-hua ZHU ; Wei-xun HE
Chinese Journal of Pediatrics 2009;47(5):391-392
Child
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Crush Syndrome
;
complications
;
Female
;
Humans
;
Male
;
Pulmonary Edema
;
complications
2.Adaptive Reaction of Actin Cytoskeleton in Podocyte Structure of Glomerulus
yu-lin, KANG ; guang-hua, ZHU ; wei-xun, HE
Journal of Applied Clinical Pediatrics 1992;0(05):-
Actin cytoskeleton in podocyte is a complicated network structure,and the stability of this structure depend on many proteins which located in slit diaphragm,the apical membrane domain and the basal membrane domain with the stimulus of mechanical stress,the actin cytoskeleton can be adaptive regulated to maintain the normal function of glomerulus,and several signal pathways involve in the process,such as RhoA/Rho kinase signal pathway and TRPC6.
3.Pleuropulmonary blastoma in adult: report of a case.
Qiao HE ; Li-jing XUE ; Xiao-hua DENG ; Yan LIU ; Guang-hua CHEN
Chinese Journal of Pathology 2009;38(2):134-135
Humans
;
Lung Neoplasms
;
metabolism
;
pathology
;
surgery
;
Lymph Node Excision
;
Male
;
Middle Aged
;
Pneumonectomy
;
methods
;
Pulmonary Blastoma
;
metabolism
;
pathology
;
surgery
;
Vimentin
;
metabolism
4.New dicyclopeptides from Dianthus chinensis.
Jing HAN ; Zhe WANG ; Yu-Qing ZHENG ; Guang-Zhi ZENG ; Wen-Jun HE ; Ning-Hua TAN
Acta Pharmaceutica Sinica 2014;49(5):656-660
One new dicyclopeptide cyclo-(L-N-methyl Glu-L-N-methyl Glu) (1), together with one new natural dicyclopeptide cyclo-(L-methyl Glu ester-L-methyl Glu ester) (2), and two known dicyclopeptides cyclo-(L-methyl Glu ester-L-Glu) (3), and cyclo-(L-Glu-L-Glu) (4), were isolated from the aerial parts of Dianthus chinensis L. Their structures were determined by spectroscopic analyses and chemical methods.
Dianthus
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chemistry
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Magnetic Resonance Spectroscopy
;
Molecular Structure
;
Plant Components, Aerial
;
chemistry
;
Plants, Medicinal
;
chemistry
5.Characteristics of antisense non-coding RNA in the INK4 locus and its roles in disease.
Chinese Medical Sciences Journal 2013;28(2):122-123
With the development of genome-wide sequencing technology, 195 types of functional long non-coding RNAs (lncRNAs) have so far been found, and their cellular roles are gradually being revealed. Now lncRNAs have become a hotspot in the life science. These small molecules exist in almost all higher eukaryotes, and have very important regulatory roles in these organisms. This review briefly summarizes recent progress in researches on antisense non-coding RNA in the INK4 locus.
Animals
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Cyclin-Dependent Kinase Inhibitor Proteins
;
genetics
;
Genetic Loci
;
Humans
;
RNA, Antisense
;
physiology
;
RNA, Long Noncoding
;
physiology
6.Function of microRNA-346 and its roles in human diseases.
Chinese Medical Sciences Journal 2012;27(2):127-128
Animals
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Chromosome Mapping
;
Disease
;
etiology
;
genetics
;
Gene Expression Regulation
;
Genome
;
genetics
;
Humans
;
MicroRNAs
;
genetics
;
physiology
;
Neoplasms
;
genetics
;
Species Specificity
7.The change of glomerular pathology in children with steroid resistant nephropathy.
Guang-hua ZHU ; Yun-jiu LUO ; Wei-xun HE ; Ming-jun FANG
Chinese Journal of Pediatrics 2004;42(3):218-219
Antibodies
;
analysis
;
Biopsy
;
Child
;
Child, Preschool
;
Disease Progression
;
Drug Resistance
;
Female
;
Fluorescent Antibody Technique
;
Humans
;
Immunoglobulin A
;
analysis
;
Kidney Glomerulus
;
immunology
;
pathology
;
Male
;
Nephrosis
;
drug therapy
;
pathology
;
Prognosis
;
Steroids
;
pharmacology
;
therapeutic use
8.Imaging Diagnosis of Vocal Cord Paralysis
Dezeng GUANG ; Qiong LIU ; Hua HE ; Jinhong LIAO ; Guixiong YE ; Shaoxian GUAN
Journal of Practical Radiology 2000;0(02):-
Objective To investigate the imaging diagnosis of vocal cord paralysis.Methods Of 58 patients,53 cases was unilateral and 5 bilateral.All patients underwent laryngeal tomography and 6 of them underwent CT.The imaging findings were analyzed.Results The tomography findings of unilateral vocal cord paralysis were as follows:dilated piriform sinus,41.5%;asymmetrical vestibule,39.6%;enlarged ventricle,71.7%;thinning cord,47.2%;paralyzed cord higher than intact cord,73.6%;cord fixed in adducent position during inspiration,100%;tilting of the thyroid cartilage,11.3%.The cord fixed in paramedian was the main appearance of bilateral vocal cord paralysis.The CT features of vocal cord paralysis included dilated piriform sinus(6 cases),enlarged laryngeal ventricle(4 cases),fixed cord in paramedian position(4 cases)and tilted anteromedially arytenoid cartilage(5 cases).Conclusion To evaluate the functional abnormality of larynx,tomography is useful and CT is well to display the laryngeal anatomic structures and changes,therefore,if the diagnosis is uncertain by tomography or the intrinsic lesions of larynx is suspected,CT is recommended.
9.Analysis of the data for inpatients with acute organophosphorous pesticide poisoning in Wucheng.
Yun-he HUO ; Xiu-hua WANG ; Xiao-ying SHANG ; Shuang-lian LIU ; Guang-shu CUI
Chinese Journal of Industrial Hygiene and Occupational Diseases 2004;22(1):32-32
Acute Disease
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Adolescent
;
Adult
;
Aged
;
Child
;
Child, Preschool
;
China
;
Humans
;
Infant
;
Inpatients
;
Insecticides
;
poisoning
;
Middle Aged
;
Organophosphorus Compounds
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Pesticides
;
poisoning
;
Poisoning
;
etiology
;
mortality
;
therapy
;
Risk Factors
;
Survival Rate
10.The synergistic effect of lidamycin and rituximab on human B cell lymphoma.
Yi-Ran SUN ; Sheng-Hua ZHANG ; Rong-Guang SHAO ; Hong-Wei HE
Acta Pharmaceutica Sinica 2014;49(2):198-203
This study aimed to investigate the synergistic effect of lidamycin (LDM) and rituximab on human B cell lymphoma Ramos cells. Cell proliferation was measured using MTS assay, cell apoptosis was analyzed by Annexin V-FITC/PI assay, the expression of apoptosis related proteins was analyzed by Western blotting, and the in vivo lymphoma inhibition was verified using BALB/c mice inoculated via tail vein using Ramos cells which stably expressed pEGFP-N1 plasmid. The results showed that, after the pretreatment with rituximab for 48 h, rituximab and LDM showed significantly synergistic effects on cell proliferation. Cells in combined treatment group had a higher apoptosis rate than that in LDM treatment group. Compared with the LDM treatment group, the expression of apoptosis-related proteins such as Cleaved caspase-3, Cleaved caspase-7, Cleaved caspase-9 and Cleaved PARP in combined treatment groups increased, and expression of cIAP-2 and Bcl-2 decreased. The result of in vivo experiment showed that, in the combined treatment group, the survival time of BALB/c mice was significantly longer than the mice in control group and LDM treatment group, and the degree of tumor accumulation and metastasis to lymph nodes and spleen was lower.
Aminoglycosides
;
pharmacology
;
Animals
;
Antibiotics, Antineoplastic
;
pharmacology
;
Antineoplastic Agents
;
pharmacology
;
Apoptosis
;
drug effects
;
Caspase 3
;
metabolism
;
Caspase 7
;
metabolism
;
Caspase 9
;
metabolism
;
Cell Line, Tumor
;
Cell Proliferation
;
drug effects
;
Drug Synergism
;
Enediynes
;
pharmacology
;
Humans
;
Inhibitor of Apoptosis Proteins
;
metabolism
;
Lymphoma, B-Cell
;
metabolism
;
pathology
;
Mice
;
Mice, Inbred BALB C
;
Mice, Nude
;
Neoplasm Metastasis
;
Neoplasm Transplantation
;
Poly(ADP-ribose) Polymerases
;
metabolism
;
Proto-Oncogene Proteins c-bcl-2
;
metabolism
;
Random Allocation
;
Rituximab
;
pharmacology