2.Which is the culprit in obesity, FTO or IRX3/5?
Chinese Journal of Endocrinology and Metabolism 2015;31(12):1013-1016
[Summary] A dozens of variants in intron 1 of FTO gene have been found to be significantly associated with obesity by a serious genome-wide association studies (GWAS) in past eight years.Very recently,The New England Journal of Medicine published an important genetic study of obesity,which challenged the point of FTO causing obesity directly.The researchers find one of the variants changes the binding ability of upstream regulator to IRX3/IRX5 and thus promotes IRX3/IRX5 expression instead of FTO.Which one is the real causal gene of common obesity,FTO,IRX3/5,both,or neither? All these questions need to be answered.
3.The value and controversy of thyroid peroxidase antibody in the diagnosis and treatment of autoimmune thyroid disease
Chinese Journal of Laboratory Medicine 2015;38(12):884-887
Thyroid peroxidase antibody (TPOAb) play an important role in the diagnosis of autoimmune thyroid disease.Chemiluminescence immunoassay (CLIA) is a new method been strongly recommended in recent years.The definition of positive value of TPOAb is inconsistent.The definition of TPOAb positive value is important for exploring the development of autoimmune thyroid disease.TPOAb is significantly increased in Hashimoto's disease and the titer is associated with the degree of infiltration and destruction of thyroid follicular.It is essential to monitor TPOAb in postpartum thyroiditis and early pregnancy.The positive of TPOAb is closely related to the adverse pregnancy outcomes caused by various risk factors.Graves disease combined with Hashimoto's must to be considered.
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