2.Forensic Medical Assessment for Neurologic Erectile Dysfunction: 58 Case Reports.
Guang-you ZHU ; Yan SHEN ; Hlong-guo LIU
Journal of Forensic Medicine 2015;31(5):369-372
To introduce the approaches and procedures of neurologic erectile dysfunction (ED) assessment in our institute, and evaluate the neurologic investigation by making an analysis of 58 cases. Diagnostic criteria of neurologic ED: nervous system injuries or diseases, abnormal clinical symptoms and signs, electrophysiological abnormalities of nervous system, abnormal results of nocturnal penile tumescence and rigidity (NPTR) (penis rigidity <60% and lasting time <10 minutes). In the group of 20 patients with the injuries of the brain, spinal cord or spinal root nerves, pudendal cortical somatic evoked potential (PCSEP), sacral reflex latency (SRL), pudendal-to-cortical motor evoked potential (PCMEP), penile sym- pathetic skin responses (PSSR) and NPTR showed abnormality by 45%, 20%, 20%, 85% and 85%, re- spectively. In 38 patients with the injuries of pelvic fracture with urethra break, PCSEP, SRL, PCMEP, PSSR and NPTR showed abnormality by 24%, 5%, 20%, 92% and 66%, respectively. In the former, 35% were identified to have severe ED, and 50%, moderate ED; in the latter, 21%, to have severe ED, 13%, medium ED, and 37%, light ED. The approaches and procedures were proved to possess excellent specificity and reliability in the assessment of neurological ED.
Erectile Dysfunction/physiopathology*
;
Evoked Potentials, Motor
;
Fractures, Bone/complications*
;
Humans
;
Male
;
Pelvic Bones/injuries*
;
Penile Erection
;
Penis/physiopathology*
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Reproducibility of Results
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Sensitivity and Specificity
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Spinal Cord Injuries/complications*
3.Protective effects of yanggan lidan granules on carbon tetrachloride-induced liver damage in mice
Shengfu YOU ; Peiyong ZHENG ; Guang JI ; Huafeng WEI ; Jie ZHAO ; Peiting ZHU
Journal of Integrative Medicine 2005;3(6):470-2
OBJECTIVE: To observe the protective effects of Yanggan Lidan Granules (YGLDG) on carbon tetrachloride (CCl(4))-induced liver damage in mice and to find out its mechanism. METHODS: A model of chronic liver damage was established in mice by intraperitoneal injection of CCl(4). After three weeks, those model mice were treated with low-, medium-, high-dose YGLDG, Danning Tablets and bifendate respectively for four weeks. Then the levels of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST), as well as the contents of superoxide dismutase (SOD) and malondialdehyde (MDA) in liver tissues were detected. RESULTS: YGLDG could significantly reduce the levels of serum ALT and AST in model mice, and the content of MDA was obviously decreased while the content of SOD was increased in liver tissue. CONCLUSION: The therapeutic effect of YGLDG on mice with CCl(4)-induced liver damage is to relieve the seriousness of liver damage, and its mechanism may relate to reducing peroxidation activity in liver tissue.
4.Automated assessment of developmental levels of epiphysis by support vector machine.
Ya-hui WANG ; Zi-shen WANG ; Hua WEI ; Lei WAN ; Chong-liang YING ; Guang-you ZHU
Journal of Forensic Medicine 2014;30(6):422-426
OBJECTIVE:
To realize the automated assessment of the levels of epiphysis of distal radius and ulna by support vector machine (SVM).
METHODS:
The X-ray films of the left wrist joints were taken from 140 teenagers aged from 11 to 19 years old as training samples. The levels of epiphysis of distal radius and ulna were divided into five developmental levels. Each level contained 28 samples. Another 35 cases were selected as independent verifying samples. SVM classification models of the five developmental levels of epiphysis of distal radius and ulna were established. The internal cross validation was made by leave one out cross validation (LOOCV), while the external validation was made by histogram of oriented gradient (HOG), and then the accuracy (PA) of testing results was calculated, respectively.
RESULTS:
The PA of SVM, LOOCV and HOG of distal radius epiphyseal level were 100%, 78.6%, and 82.8%, respectively; whereas the PA of SVM, LOOCV and HOG of distal ulna epiphyseal level were 100.0%, 80.0% and 88.6%, respectively.
CONCLUSION
The SVM-based automatic models of the growth stage of distal ra- dius and ulna appear to have certain feasibility, and may provide a foundation for software development of bone age assessment by forensic medicine.
Adolescent
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Bone Development/physiology*
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Child
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Epiphyses/growth & development*
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Female
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Humans
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Image Processing, Computer-Assisted/methods*
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Male
;
Radius/growth & development*
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Support Vector Machine
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Ulna/growth & development*
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Wrist/growth & development*
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Wrist Joint/growth & development*
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Young Adult
5.Comparison of several visual evoked potential tests in measuring normal adults' real visual acuity.
Journal of Forensic Medicine 2007;23(4):254-257
OBJECTIVE:
To study and compare several measures of pattern visual evoked potential in measuring normal adults' real visual acuity.
METHODS:
Forty normal eyes were selected to test the pattern reversal visual evoked potential, black-white scanning pattern visual evoked potential, red-black scanning pattern visual evoked potential, respectively. Their experiment visual acuity was compared with their real visual acuity.
RESULTS:
The black-white scanning pattern visual evoked potential and the red-black sweep pattern visual evoked potential were more accurate, more convenient, and much faster in measuring real visual acuity than the pattern reversal visual evoked potential.
CONCLUSION
Pattern reversal visual evoked potential, black-white scanning pattern visual evoked potential, and red-black scanning pattern visual evoked potential all can be used in forensic medical examination of eye injuries.
Adolescent
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Adult
;
Analysis of Variance
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Evoked Potentials, Visual/physiology*
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Female
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Forensic Medicine/methods*
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Humans
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Male
;
Middle Aged
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Pattern Recognition, Visual
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Vision Tests/methods*
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Visual Acuity/physiology*
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Young Adult
6.Reliability study on quantitative detection of extensor digitorum brevis strength with needle electromyography and nerve conduction.
Dong GAO ; Qing XIA ; Dan RAN ; Dong TIAN ; Guang-You ZHU ; Li-Hua FAN
Journal of Forensic Medicine 2013;29(6):409-413
OBJECTIVE:
To study the objectivity and reliability of needle electromyography and nerve conduction for detection of musculus extensor digitorum brevis strength, which may provide a basis for establishing a quantitative detection of muscle strength in forensic clinical study.
METHODS:
Forty-four healthy people were enrolled as the subjects, and during toe dorsiflexion, the following items including needle electromyography indexes, motor unit potential (MUP) amplitude, MUP count, recruitment reaction type, and nerve conduction detection indexes, compound muscle action potential (CMAP) amplitude, CMAP latent period and motor nerve conduction velocity (MNCV), were simultaneously detected under the cooperation and disguise condition.
RESULTS:
Under the cooperation condition, regardless of the same operator or different operators, there were good test-retest reliabilities in MUP amplitude, CMAP amplitude, CMAP latent period and MNCV, while there were normal test-retest reliabilities in MUP count and recruitment reaction type and the repeatability of the same operator was slightly better than the repeatability between different operators. Under the disguise condition, test-retest reliabilities of MUP amplitude, CMAP amplitude, CMAP latent period and MNCV were relatively high, while test-retest reliabilities of MUP count and recruitment reaction type were relatively low.
CONCLUSION
There are good test-retest reliabilities in MUP amplitude, CMAP amplitude, CMAP latent period and MNCV, which can be conducive to comparison between different operators and results at various times; MUP count and recruitment reaction type, which can be easily affected by subjectivity of operators and examinees, can be used to differentiate whether an examinee disguises or not. The indexes used to objectively judge muscle strength remain to be further investigated.
Electrodes, Implanted
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Electromyography
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Humans
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Muscle Strength/physiology*
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Muscle, Skeletal/innervation*
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Neural Conduction/physiology*
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Reproducibility of Results
;
Toes
8.Comparison of structural characteristics and anticoagulation activity of enoxaparin sodium with different degree of 1,6-anhydro derivatives.
He ZHU ; You-Jing LIÜ ; Xian-Wei HAN ; Shi-Long LIU ; Jie-Jie HAO ; Xiao-Liang ZHAO ; Guang-Li YU
Acta Pharmaceutica Sinica 2014;49(7):1049-1053
The fine structure of enoxaparin sodium samples with different degree of 1,6-anhydro derivatives were analyzed with polyacrylamide gel electrophoresis, high performance liquid chromatography, ultraviolet spectroscopy, infrared spectroscopy and nuclear magnetic resonance spectroscopy. A further study of anticoagulation activity of enoxaparins was performed, including those on their inhibition activities of coagulation factor Xa (FXa) and thrombin (FIIa). The results showed that the anti-FXa and -FIIa activities of enoxaparins with different degree of 1,6-anhydro derivatives (20.0%-39.7%) with similar structure characteristics, had decreasing tendency when the degree of 1,6-anhydro derivatives increased. Especially, the anti-FXa activity was sensitive to the change of the degree of 1,6-anhydro derivatives.
Anticoagulants
;
chemistry
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Enoxaparin
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chemistry
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Factor Xa Inhibitors
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chemistry
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Thrombin
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antagonists & inhibitors
9.Effectiveness of Danning Tablet in patients with non-alcoholic fatty liver of damp-heat syndrome type: a multicenter randomized controlled trial.
Guang JI ; Jiangao FAN ; Jianjie CHEN ; Lungen LU ; Lianjun XING ; Peiyong ZHENG ; Honggang GU ; Huafeng WEI ; Shengfu YOU ; Peiting ZHU
Journal of Integrative Medicine 2008;6(2):128-33
OBJECTIVE: To evaluate the efficacy and safety of Danning Tablet (DNT) in patients with non-alcoholic fatty liver disease (NAFLD) of damp-heat syndrome type. METHODS: A multicenter, randomized, double-blinded and positive drug parallel controlled trial was performed. One hundred and thirty-five patients were enrolled into the study and divided into two groups: DNT-treated group (n=102) and ursodeoxycholic acid (UDCA)-treated group (n=33). Body mass index (BMI), principal symptoms, liver function, blood lipids, iconographic, and compositional parameters were measured before and after treatment, respectively. RESULTS: In the two groups, BMI, distress in hepatic region, fatigue, anorexia, liver function, blood lipids and iconographic parameters were significantly improved, and the improvements of BMI, distress in hepatic region were better in DNT-treated group than in UDCA-treated group. The histological study also showed that DNT had positive effect in treatment of NAFLD. CONCLUSION: DNT is an effective drug to treat patients with NAFLD of damp-heat syndrome type and is more effective than UDCA.
10.Analysis of Doppler ultrasonography in penile artery.
Guang-you ZHU ; Hong-guo LIU ; Mei-ying CHEN
Journal of Forensic Medicine 2005;21(3):180-182
OBJECTIVE:
To study nomal valuels of PI, RI and S/D in healthy male penile dorsum artery (DA) and cavernosal artery (CA).
METHODS:
257 healthy mature men were divided into 5 groups by age. Group 1: <30, n=65; Group 2: 30-39, n=83; Group 3: 40-49, n=61; Group 4: 50-59, n=38; Group 5: > or = 60, n=10. Hibateral PI, RI and S/D values of penile dorsum artery and cavernosal artery were examined by Logidop(r)2 Type Digital Doppler Ultrasonography.
RESULTS:
There were no significant difference for PI, RI and S/D of penile dorsum artery and cavernosal artery not only in personal left and right artery but also in different age groups. Normal values advised: (1)LDA:PI 1.43-3.43, RI 0.72-0.92, S/D 2.68-10.56. (2)RDA PI 1.47-3.47, RI 0.73-0.93, S/D 3.27-10.09. (3)LCA:PI 1.49-3.21, RI 0.74-0.90, S/D 3.17-9.55. (4)RCA:PI 1.93-3.27, RI 0.72-0.90, S/D 3.22-9.42.
CONCLUSION
Doppler ultrasonography is a favorable method in filtering penile arterial function.
Adult
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Age Factors
;
Arteries/diagnostic imaging*
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Blood Flow Velocity
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Blood Pressure
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Humans
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Impotence, Vasculogenic/diagnosis*
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Male
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Middle Aged
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Penis/diagnostic imaging*
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Ultrasonography, Doppler