OBJECTIVE:To provide reference for reconstructing medical regulatory system in China. METHODS:Through in-troducing medical regulatory setting mode in Britain and USA,combining the situation and problems of medical regulatory setting in China,and the assumption was put forward for medical regulatory system construction. RESULTS & CONCLUSIONS:Adher-ing to the principle of legalization,independence and speciality,Britain and USA set up various types medical regulatory in each professional field led by health departments. These medical regulatory institutions are charged with drug instrument regulation,medi-cal regulation monitoring,medical insurance monitoring,and other responsibilities. In China,medical regulatory function scatters in Food & Drug Administration,Health and Family Planning Department,Human Social Security Department,Price Department, etc.There are some problems which go against the relief of“difficulty and high cost of getting medical service”and“falsely high drug price”,such as low legalization,unclear regulatory function,poor independence and speciality. So,“super health”medical regulatory system,covering administration department,industry regulator institutions and professional technology institutions led by National Health and Family Planning Commission,should be established through grasping“super-ministries”reform opportunity and integrating medical regulatory function of Food & Drug Administration,Health and Family Planning Department,Human So-cial Security Department,by referring to Britain and USA experience.

Combined Modality Therapy ; Early Diagnosis ; Humans ; Mouth Neoplasms ; diagnosis ; therapy

·Electroretinogram (ERG) is an objective examination in evaluating retinal function, which is also suitable to evaluate retinal function of multiple ophthalmic diseases. ln recent years, studies have found that ERG can find functional changes prior to morphological changes of fundus examination in early diabetics, which provides a new way for researches of pathological mechanism, early diagnosis and prognosis evaluation for diabetic retinopathy, and then also provides a new therapy for diabetic retinopathy. ln this paper, using ERG in the diagnosis of early diabetic retinopathy was reviewed.

Objective: To rapidly construct bone-implant complex finite element model series using worksheet-driven CAD and finite element analysis software. Methods: The alveolar ridge and implant models were constructed by CAD software separately. Based on those models, the CAD models of different compositions of cancellous and compact bone and different implants were built and assembled. Electronic form software was utilized to drive the change of dimension in the process. All the models were imported into finite element analysis software and converted to finite element models after installation of different parts in the CAD software. Results: A total of 300 finite element models for different alveoli-implants were obtained through activating different versions of models. The models were of high quality and had no interference with each other. Conclusion: Our modeling method is rapid and highly effective. The series of models basically covers all types of alveoli,which provides a tool for studying the biomechanical characters of implants.

Animals ; Botulinum Toxins, Type A ; pharmacology ; Capsaicin ; pharmacology ; Carbachol ; pharmacology ; Humans ; Keratoconjunctivitis ; surgery ; Phenylephrine ; pharmacology ; Saliva ; drug effects ; Submandibular Gland ; drug effects ; transplantation ; Translational Medical Research

Humans ; Practice Guidelines as Topic ; Submandibular Gland ; transplantation ; Transplantation, Autologous

Objective To explore the changes of brain-derived neurotrophic factor(BDNF) after repeated febrile seizures (FS).Methods Fifty-one male SD rats were divided into 3 groups randomly: normal group (NC group,n=14) ,hyperthermic group (HC group,n=19),FS group(n=18). FS were induced by hot water bath.The level of BDNF in hippocampus homogenate were measured by enzyme linked immunosorbent assay (ELISA) and the expression of BDNF were measured by immunohistochemistry.The apoptosis of the brain cells were determined by terminal deoxynucleotide mediated nick end labeling (TUNEL).The results were analysed with the software of SPSS 13.0.Results The level of BDNF in hippocampus in FS group(89.90?12.51) ng/g was significantly higher than that in NC group(54.43?18.92) ng/g and HC group(64.09?15.03) ng/g (Pa

Objective To observe the expressions of nuclear factor-?B(NF-?B)in brain tissue of rats with repeated febrile seizures(FS)and explore its significance in brain injury of rats with FS.Methods Fifty-one male SD rats were divided into 3 groups according to random number method:normal group(n=14),hyperthermic group(n=19),FS group(n=18).FS models were induced by placing rats in warm bath;the rats without FS after warm-bath were assigned as hyperthermic group ;the normal controls received no treatment.The expression of NF-?B was measured by immunohistochemistry.The apoptosis of brain tissue was determined by terminal deoxynucleotidyl transferase biotin-dUTP nick end labeling(TUNEL).SPSS 13.0 software was applied for statistical treatment.Results In FS group,the number of the NF-?B positive neuron increased much more than that of hyperthermic group and normal group(Pa

Objective To explore the change of somatostatin(SS)in brain areas of juvenil rats with repeated febrile seizures(FSs)and hyparthermia.Methods Fifty-one male SD rats were divided randomly into 3 groups:normal group(NC group,n=14),hyperthermic group(HC group,n=19)and febrile seizure group(FS group,n=18).FS were induced by placing rats in a bath of water.The expressions of SS in DG,CA3,CA1 and CTL were measured by immunohistochemistry.The level of SS in hippocamps of these rats were determined by radioimmunoassay.Results The results of immunohistochemistry shew in HC group,the number of the SS positive neuron were increased in DG(21.10?2.51),CA3(10.60?2.41)in FS group,which was less than that in NC group(10.50?2.12,6.90?2.02),there was no difference in CA1 and CTL.The result of Radioimmunoassay:the level of SS in hippocampus in HC group[(53.74?7.56)ng/g]was higher than that in FS group[(39.54?7.74)ng/g](P0.05).Conclusion There is different change of somatostatin content in some brain areas of rats with repeated febrile seizure,which suggest that SS can increase the affectivity of seizure and promote the seizure.

Asthma was considered to be a kind of chronic airway inflammatory diseases mediated by eosinophils(EOS),mast cells,T lymphocytes for a long time,and the typical pathologic features of asthma was airway EOS inflammation.The current study had found out that elevated neutrophils in airway were seen in severe asthma,and this kind of asthma had a poor response to corticosteroids.Impaired neutrophil chemotaxis and apoptosis of airway neutrophilia may be associated with persistent neutrophilic inflammation in the airways of severe asthma.A deep research into the mechanisms of neutrophilic phenotypes asthma would contribute to the new strategy of therapy.This article discusses a range of topics related to the role of neutrophilic inflammation in severe asthma in children,which were organizedas follows.