Androgen receptors appear to play a significant role in the hepatocarcinogenesis.Androgen receptors are found to be expressed in liver tumor,and the overexpression of androgen receptor is associated with poor prognosis.Recent researches have indicated that androgen receptors regulate various cellular events in liver carcinogenesis through various ways,and androgen receptor could be a potential cancer therapeutic target in hepatocellular carcinoma.

Objective To assess the changes of the cardiac function of the patients with myocardial infarction(MI) after the coronary revascularization(CRV) by 2D echocardiography and Doppler tissue imaging(DTI).The effects of CRV on cardiac function were explored.Methods The global and regional wall functions were quantitatively analyzed in 49 patients with MI by 2D echocardiography and DTI(Aspen imaging systems).Results The regional function was improved prior to the global function in patients with MI after successful CRV.Conclusions CRV is one of the important factors for the cardiac function improvement in patients with MI.

To evaluate the left ventricular diastolic function with Doppler and 2D echocardiography in patients with mild and moderate hypertension. 202 patients with hypertension were involved in this study. The parameters of Doppler and 2D echocardiography were compared with clinical materials of the patients. The results of this study showed that age, diabetes, left ventricle hypertrophy and duration of hypertension were related to the left ventricular diastolic function, whereas hyperlipidmia, smoking and alcohol drink had less effect on left diastolic function. The results of this study suggested that there were diastolic dysfunction in patients with hypertension, and Doppler and 2D echocardiography could be used to detect left ventricular diastolic function.

0.05).Both of them had a linear correlativity,correlative coefficient closed to 1.Conclusions Coronary artery endothelial function and brachial artery endothelial function had a high linear correlativity.

The incidence of pancreatic neuroendocrine neoplasms is progressively growing.The clinical manifestation and treatment of this disease are complicated.Multi disciplinary combination therapy is needed to improve prognosis and life quality of patients.

Cell cycle-related kinase (CCRK) as a novel CDK-activating kinase plays a significant role in cell cycle regulation.Related studies confirm that CCRK is overexpressed in various tumors,and is associated with poor prognosis of the patients,which indicates that CCRK takes part in the generation and development of the tumor.

0.05). The incidence of anastomotic leakage in the control group (16.7%) was higher than that of the study group (4.3%). The area of collagen fibrils 3 d, 5 d and 7d after intestinal anastomosis in the study group were significantly more than that in the control group ( P

Objective:To study the immune response to murine pancreatic carcinoma by bone marrow-derived dendritic cells(BM-DCs) modified with interleukin-23 after acquiring antigen from apoptotic pancreatic carcinoma cell.Methods:The murine IL-23 cDNA was sub-cloned into dual-expression vector.DCs were pulsed with apoptotic tumor cell antigen after transduced with interleukin-23 gene.The immune preventative and immunotherapeutic effects of DC vaccines on mice with pancreatic cancer were assessed.Results:IL-23 protein could apparently increase the antigen presenting ability of DC.After the vaccination of DC vaccines.IFN-? production in treatment group were significantly more than that of control group(P

Objective To evaluate the left ventricular systolic function of the patients who received coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI), in order to compare the clinical effectiveness of these two operations. Methods 61 patients with coronary artery disease were enrolled in this study. 28 patients received CABG and 33 patients PCI. The left ventricular systolic function was assessed by two-dimensional (2D) echocardiography and Doppler tissue imaging (DTI) (Aspen imaging systems). Results The left ventriculus ejection fraction (EF) and the average velocity of systolic wave (S) of mitral annular were increased after CABG or PCI. There was no statistical significant difference in degree of improvement in the left ventricular systolic function between two operations. Conclusions The results of this study suggested that the global left ventricular systolic function was improved after either successful CABG or PCI, with no signiticant difference in clinical efficaciousness.

Objective To explore the effect of glutamine on immune function of rat with obstructive jaundice and its possible mechanism. Methods Fifty male Wistar rats were randomly divided into three groups: Control group (n=10), obstructive jaundice group (n=20) and glutamine treatment group (n=20). The serum concentration of TNF-?, IL-10 was detected by using radioimmune method. Liver function was measured through automated biochemistry analyzer. The animal model of obstructive jaundice was established by ligating the rat's common bile duct. Bacteria cultures were performed with the rat's tissues of lung, spleen, liver and kidney respectively. Resu- lts Compared with control group, obstructive jaundice group showed statistically lower serum level of TNF-?, and statistically higher serum level of IL-10, TBIL, ALT and AST during the first and the second week after ligation of common bile duct. During the first and second week after administration of glutamine, the serum TNF-? of glutamine treatment group was statistically higher than that in control group and obstructive jaundice group. Meanwhile, glutamine treatment group showed statistically lower serum level of IL-10, TBIL, ALT and AST than obstructive jaundice group. There were statistically less bacteria translocations in glutamine treatment group than those in obstructive jaundice group. Conclusion Glutamine can increase the immune function by changing serum concentration of TNF-?, IL-10 and decrease the bacteria translocation.