"12th Five-year Plan" period is critical to build China social security and disabled service systems. Assistive devices researchas an important technical support for the systems faces a very difficult task. Relevant departments and associations need to play a role on theassistive devices research. Co-ordination and to strengthen macro-coordination, related research institutions, enterprises and so on need tofurther understand the China's basic situation and the main task of the current research work. The paper discussed the basic task of assistivedevices research based on the work policies and demand.

BACKGROUND: At present, the meniscus injury is very common, and can lead to serious injury of the knee joint.Meniscus biomechanics has been reported, but no studies have concerned the biomechanical characteristics of the meniscus in knee buckling during gait under different loading conditions.OBJECTIVE: To simulate and analyze the biomechanical characteristics of the knee joint meniscus under different loading conditions using finite element method.METHODS: Based on the knee magnetic resonance imaging data of normal adult volunteers, three-dimensional finite element model of knee joint was reconstructed. The stress, distribution and changes in the meniscus under different flexion angles were analyzed at 300 N, 400 N and 500 N.RESULTS AND CONCLUSION: (1) Under the respectively loading conditions of 500 N, 400 N and 300 N, the maximum stress point all from the place of posterior horn of medial meniscus anterior surface of tibia moved to the posterior margin of the anterior tibial attachment of the lateral meniscus, and the maximum displacement all from the place of midpoint of the inner edge of the medial meniscus moved to front outer edge of the lateral meniscus during normal dynamic buckling process of 0°, 30°, 60° and 90°, and the range of stress and displacement of lateral meniscus was greater than that of medial meniscus; simultaneously, the distribution range of stress and displacement was proportional to the size of the loading and the angle of the buckling. (2) The three-dimensional finite element model of the knee joint meniscus can be used to effectively dynamically simulate the distribution of force and displacement under different loading conditions, and can provide evidence for speculation of the mechanism of the injury of the meniscus in clinic.

BACKGROUND:At present, although the study of three-dimensional finite element biomechanical analysis of knee joint meniscus has been reported and we have a certain understanding of the biomechanical changes of the meniscus, but the dynamic simulation of the knee meniscus in the same load conditions in the process of biomechanical analysis of the knee meniscus is less reported. OBJECTIVE:To analyze the biomechanical characteristics of the knee joint meniscus under different flexion angle by using analogue simulation of finite element method. METHODS:Based on knee MRI data of the normal adult volunteers, the medicine finite element simulation software Mimics10.01 and reverse engineering software Rapidform XOR3 were utilized to reconstruct three-dimensional finite element model of knee joint meniscus. The advanced finite element analysis software Abaqus6.10-1 was utilized for analogue simulation and for analyzing biomechanical changes during flexion under vertical load of 300 N. RESULTS AND CONCLUSION:(1) While the knee joint flexed at 0°, 30°, 60° and 90°, with the increase of angle, maximum stress point moved from the anterior edge of tibia attachment surface of the medial meniscus posterior angle to the posterior edge of tibia attachment surface of the lateral meniscus anterior angle, and the stress range of lateral meniscus was greater than that of the medial meniscus. (2) The maximal displacement point moved from the midpoint of inner edge of the medial meniscus to the front outer-upper edge of the lateral meniscus at knee flexion of 0°, 30°, 60° and 90°. Moreover, the range of displacement of lateral meniscus was bigger than the medial meniscus. (3) These findings suggest that the meniscus is the major bearing structure in the process of knee flexion. The lateral meniscus injury rate is greater than the medial meniscus in process of exercise, which is associated with large stress and displacement.

Objective To investigate the clinical efficacy of low molecular weight heparin combined with psychological intervention in the prevention of deep venous thrombosis (DVT) in patients with varicose great saphenous vein. Methods Two patients underwent surgical varicosis of great saphenous vein saphenous vein ligation and stripping surgery group, with low molecular weight heparin to prevent deep venous thrombosis, the study group with low molecular weight heparin combined with psychological intervention, prevention and control of postoperative deep venous thrombosis, the incidence of records of two groups of patients with postoperative lower extremity deep vein thrombosis. Results The incidence of deep vein thrombosis (2.04％) in the study group was significantly lower than that in the control group (14.29％) (P<0.05), suggesting that the study group had better effect on prevention of deep vein thrombosis after operation. Conclusion The combination of psychological intervention and low molecular weight heparin can achieve more ideal prevention effect of deep vein thrombosis after operation of great saphenous varicose vein, which is beneficial to protect the quality of life and life safety of patients.

Objective To investigate the imaging finding,the pathologic bases,and the diagnostic value of nodule notch due to pleural indentation (NNPI),and to evaluate the potential role of multiplanar reconstruction (MPR) in the diagnosis of small peripheral lung cancer (SPLC) associated with pleural indentation (PI).Methods (1) 91 cases of SPLC and 59 cases of benign nodule confirmed by pathology were collected in this paper.A correlative study was done between the two groups.Eleven fresh lobectonic specimens from 9 cases of SPLC and 2 cases of benign nodule were collected.A correlative study to the preoperative CT scans,postoperative scans of the inflated specimens with the gross pathology of the specimens was done.(2) Twenty cases of SPLC and 12 cases of benign nodule,associated with PI,were collected in the study about MPR.Attention was focused on its role in showing NNPI.Results (1) NNPI was depicted as follows: On the position of the connection between the nodule and the line associated with PI,and a notch was shaped on the margin of nodule.The specificity of NNPI to malignant PI was 96.5%.(2) On MPR image,the occurrence of NNPI (80%) was higher than that on CT scans (? 2=13.205,P

Objective To understand the bronchovascular nodule notch sign based on pathology and to evaluate the potential role in detecting this "sign"by multiplanar reconstruction(MPR).Methods ① 91 cases of small peripheral lung cancer (SPLC) and 55 cases of benignant nodule,confirmed by pathology were analysed.11 fresh lobectonic specimens including 9 cases with SPLC and 2 cases with benignant nodule were collected to make the gross pathologyical sections.The bronchovascular convergences in benign and malignant nodule were analysed comparatively.② MPR in 20 cases with malignant nodule and 13 cases with benign nodle were performed in order to observe the bronchovascular convergences.Results ① The specialty of nodule notch sign was 95.2% for malignant tumors.② The detecting rate of nodule notch sign on MPR in malignant nodule was 70%,which was of significant difference between MPR and plain CT scan.Conclusion "Notch sign" is of important value in the diagnosis of SPLC associated with BVC.The detected rate of "notch sign"will be improved by spiral CT MPR.

Objective To explore the mechanism of the microglia inflammatory response through observing the changes of interleukin-1 receptor associated kinase-4(IRAK-4) expression in murine N9 microglia cells under hypoxia.Methods N9 cells were exposed to 3%O2,5%CO2,92%N2 for 1,3,6,12 and 24 h respectively.The IRAK-4 protein level was detected by Western blotting and the celluar change was observed by laser scanning confocal microscope(LSCM).The TNF-? level was measured by ELISA.Results After hypoxia,the expression of IRAK-4 protein was increased in a time-dependent manner.The elevation began at 1 h after hypoxia,increased significantly at 3 h(P0.05).The fluorescence intensity of IRAK-4 also increased with the extension of anoxic time.The TNF-? level change were similar.There were significant positive correlations between the expression of IRAK-4 and TNF-?(P

Animals ; Antineoplastic Agents ; therapeutic use ; Benzamides ; Dasatinib ; Drug Resistance, Neoplasm ; drug effects ; Fusion Proteins, bcr-abl ; genetics ; metabolism ; Humans ; Imatinib Mesylate ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive ; drug therapy ; genetics ; metabolism ; Piperazines ; therapeutic use ; Protein-Tyrosine Kinases ; antagonists & inhibitors ; Pyrimidines ; pharmacology ; therapeutic use ; Thiazoles ; pharmacology ; therapeutic use