Objective This study was designed to determine the serum CA-Hb 3 level in human colorectal carcinoma and analyze its clinical significance.Methods The level of serum CA-Hb 3 was measured by ELISA in 72 patients with colorectal carcinoma and 36 normal persons as the control group.Results The level of serum CA-Hb 3 in colorectal carcinoma was significantly higher than that of normal control .The level of serum CA-Hb 3 was positively related with tumor size,clinical pathological staging.With progression of clinical pathological staging (Dukes'stage),the level of CA-Hb 3 increased significantly,but its relation to tumor size,age,and sex was not significant.Conclusion Serum CA-Hb 3 assay may be a potentially valuable marker in assessment of pathological staging and judgement of clinical prognosis of colorectal carcinoma.

Objective To explore the relationship of calcium channel,voltage-dependent,L type,alpha 1C subunit (CACNA1C) gene polymorphism with schizophrenia.Methods A total of 1 432 patients with schizophrenia and 1 153 healthy controls were selected using Ligase Detection Reaction-Polymerase Chain Reaction(LDR-PCR) to analyze the genotypes of CACNA1C gene (rs1006737 and rs1024582).Results The allelic and genotypic distributions in rs1006737 between patients with schizophrenia (A,G allele:5.3％,94.7％;A/A,A/G,G/G genotypes:0.2％,10.2％,89.6％) and healthy controls (A,G allele:4.0％,96.0％;A/A,A/G,G/G genotypes:0.4％,7.4％,92.3％) had statistically significance after analysis (P＜0.05).The allelic and genotypic distributions in rs1024582 between patients with schizophrenia (A,G allele:4.9％,95.1％;A/A,A/G,G/G genotypes:0.2％,9.3％,90.5％) and healthy controls (A,G allele:4.0％,96.0％;A/A,A/G,G/G genotypes:0.1％,7.8％,92.1％) did not have statistically significance after analysis (P＞0.05).The G allele of rs1006737 (OR=1.332,95％CI=1.016-1.746) was associated with the risk of schizophrenia(P＜ 0.05).Conclusion This research supports that CACNA1C gene rs1006737 polymorphism is associated with schizophrenia in Han Chinese.

Objective To compare and analyze the efficacy and risks of percutaneous CT/ultrasound-guided bipolar radiofrequency ablation(RFA)under local anesthesia with robotic-assisted laparoscopic partial nephrectomy(RAPN)for the treatment of sporadic small renal mass.Methods A retrospective study was conducted on 93 consecutive patients with T1a stage small renal mass during Mar.2019 and Oct.2021.Among them,51 underwent RAPN,and 42 underwent RFA.General information,tumor characteristics,perioperative and follow-up data were collected and statistically analyzed.Results There were no significant differences in general information and tumor characteristics between the two groups(P＞0.05).The operation time[(96.0±20.0)min vs.(113.5±24.1)min,P＜0.001],hospital stay[(3.5±0.8)day vs.(6.9±1.8)day,P＜0.001],and hospital costs[(2.4±0.7)ten thousand yuan vs.(6.6±0.4)ten thousand yuan,P＜0.001]were significantly decreased in the RFA group than in the RAPN group.There were no significant differences in the incidence of perioperative complications and long-term disease-free survival rate between the two groups(P＞0.05).However,the difference between one-year postoperative estimated glomerular filtration rate(eGFR)and preoperative eGFR was significantly lower in the RFA group than in the RAPN group[-2.3(-4.7-1.3)mL/(min·1.73 m2)vs.-5.0(-9.1 2.8)mL/(min·1.73 m2),P=0.003],and the reduction of one-year postoperative creatinine and preoperative creatinine was slightly lower in the RFA group than in the RAPN group[4.0(-0.2-5.5)μmol/L vs.4.5(1.8-9.2)μmol/L,P=0.122].Conclusion RFA can achieve comparable disease-free survival rate as RAPN in the treatment of T1a renal tumor,and can effectively preserve renal function,reduce medical costs,save medical resources,and lower the incidence of perioperative complications.